The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats
Open accessAbstract
Despite its early discovery and high sequence homology to the other VEGF family members, the biological functions of VEGF-B remain poorly understood. We revealed here a novel function for VEGF-B as a potent inhibitor of apoptosis. Using gene expression profiling of mouse primary aortic smooth muscle cells, and confirming the results by real-time PCR using mouse and rat cell lines, we showed that VEGF-B inhibited the expression of genes encoding the proapoptotic BH3-only proteins and other apoptosis- and cell death-related proteins, including p53 and members of the caspase family, via activation of VEGFR-1. Consistent with this, VEGF-B treatment rescued neurons from apoptosis in the retina and brain in mouse models of ocular neurodegenerative disorders and stroke, respectively. Interestingly, VEGF-B treatment at the dose effective for neuronal survival did not cause retinal neovascularization, suggesting that VEGF-B is the first member of the VEGF family that has a potent antiapoptotic effect while lacking a general angiogenic activity. These findings indicate that VEGF-B may potentially offer a new therapeutic option for the treatment of neurodegenerative diseases.
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Cites
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653
Common mechanisms of nerve and blood vessel wiring
Carmeliet, P., & Tessier-Lavigne, M. (2005) · Nature · doi:10.1038/nature03875 · Cited by 1,085
Puthalakath, H., Villunger, A., O'Reilly, L. A., Beaumont, J. G., Coultas, L., Cheney, R. E., Huang, D. C. S., & Strasser, A. (2001) · Science · doi:10.1126/science.1062257 · Cited by 656
Cited by
Role and Therapeutic Potential of VEGF in the Nervous System
Ruiz de Almodovar, C., Lambrechts, D., Mazzone, M., & Carmeliet, P. (2009) · Physiological Reviews · doi:10.1152/physrev.00031.2008 · Cited by 448
Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Koch, A. W., Scotney, P., Lee, C., Arjunan, P., Dong, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813061106 · Cited by 307
Self-citationVEGF ligands and receptors: implications in neurodevelopment and neurodegeneration
Carmeliet, P., & de Almodovar, C. R. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1283-7 · Cited by 173
Mahoney, E. R., Dumitrescu, L., Moore, A. M., Cambronero, F. E., De Jager, P. L., Koran, M. E. I., Petyuk, V. A., Robinson, R. A. S., Goyal, S., Schneider, J. A., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0458-5 · Cited by 150
Pepe, M., Mamdani, M., Zentilin, L., Csiszar, A., Qanud, K., Zacchigna, S., Ungvari, Z., Puligadda, U., Moimas, S., Xu, X., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.220855 · Cited by 93
Metadata
- Authors
- Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., Hua, J., Matsuo, O., Fong, G.-H., Ding, H., Cao, Y., Becker, K. G., Nash, A., Heldin, C.-H., & Li, X.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-02-01
- Volume
- 118
- Issue
- 3
- Pages
- 913-23
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2056110140
- Cited by
- 194
- References
- 4
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., Hua, J., Matsuo, O., Fong, G.-H., Ding, H., Cao, Y., Becker, K. G., Nash, A., Heldin, C.-H., & Li, X. (2008). VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats. Journal of Clinical Investigation. https://doi.org/10.1172/jci33673
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
