Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
Abstract
Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.
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At least in some settings, detachment from the extracellular matrix triggers MOMP upon activation of the BH3-only proteins BIM and BMF.
“At least in some settings, detachment from the extracellular matrix triggers MOMP upon activation of the BH3-only proteins BIM and BMF [137, 235].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [137]
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- Authors
- Puthalakath, H., Villunger, A., O'Reilly, L. A., Beaumont, J. G., Coultas, L., Cheney, R. E., Huang, D. C. S., & Strasser, A.
- Affiliations
- The Royal Melbourne Hospital (AU)
- The Walter and Eliza Hall Institute of Medical Research, Melbourne, P.O. Royal Melbourne Hospital, 3050 VIC, Australia.
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Strasser, Andreas
- ORCID
- Venue
- Science
- Published
- 2001-09-07
- Volume
- 293
- Issue
- 5536
- Pages
- 1829-1832
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993059855
- Cited by
- 656
- References
- 24
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 13 · 2023: 16 · 2022: 12 · 2021: 41 · 2020: 10 · 2019: 15 · 2018: 15 · 2017: 13 · 2016: 18 · 2015: 23 · 2014: 14 · 2013: 25 · 2012: 27
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (#CA 80188, R01CA080188)
- National Institute on Deafness and Other Communication Disorders (R29DC003299)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- BMF, BH3-only proteins, apoptosis, myosin V, anoikis, Bcl-2 family proteins, cytoskeleton, building information modeling, protein translocation
- MeSH terms
- Bcl-2-Like Protein 11, Amino Acid Sequence, Animals, Calmodulin-Binding Proteins, Carrier Proteins, Cell Line, Cytoskeleton, Dyneins, Humans, Membrane Proteins, Molecular Sequence Data, Mutation, Neoplasm Proteins, Nerve Tissue Proteins, Protein Binding, Proto-Oncogene Proteins, RNA, Messenger, Transfection, Protein Structure, Tertiary, Proto-Oncogene Proteins c-bcl-2, Molecular Motor Proteins, Two-Hybrid System Techniques, Gene Expression Profiling, Protein Transport, Anoikis, Myosin Type V, Drosophila Proteins, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Mice, Myeloid Cell Leukemia Sequence 1 Protein
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