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Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
Open accessAbstract
The mechanism of mitochondrial damage, a key contributor to renal tubular cell death during acute kidney injury, remains largely unknown. Here, we have demonstrated a striking morphological change of mitochondria in experimental models of renal ischemia/reperfusion and cisplatin-induced nephrotoxicity. This change contributed to mitochondrial outer membrane permeabilization, release of apoptogenic factors, and consequent apoptosis. Following either ATP depletion or cisplatin treatment of rat renal tubular cells, mitochondrial fragmentation was observed prior to cytochrome c release and apoptosis. This mitochondrial fragmentation was inhibited by Bcl2 but not by caspase inhibitors. Dynamin-related protein 1 (Drp1), a critical mitochondrial fission protein, translocated to mitochondria early during tubular cell injury, and both siRNA knockdown of Drp1 and expression of a dominant-negative Drp1 attenuated mitochondrial fragmentation, cytochrome c release, caspase activation, and apoptosis. Further in vivo analysis revealed that mitochondrial fragmentation also occurred in proximal tubular cells in mice during renal ischemia/reperfusion and cisplatin-induced nephrotoxicity. Notably, both tubular cell apoptosis and acute kidney injury were attenuated by mdivi-1, a newly identified pharmacological inhibitor of Drp1. This study demonstrates a rapid regulation of mitochondrial dynamics during acute kidney injury and identifies mitochondrial fragmentation as what we believe to be a novel mechanism contributing to mitochondrial damage and apoptosis in vivo in mouse models of disease.
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“For example, mitochondrial fission occurs in the kidneys and heart after acute ischemia/reperfusion injury in mice, and prevention of this process is beneficial (5, 32).”
From Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2012) · cites this paper as [5]
In the citing paper
“For example, mitochondrial fission occurs in the kidneys and heart after acute ischemia/reperfusion injury in mice, and prevention of this process is beneficial (5, 32).”
From Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2012) · cites this paper as [5]
In the citing paper
“Moreover, these studies revealed that silencing of Drp1 expression was not associated with reduced translocation of the pro-apoptotic protein Bax to mitochondria, suggesting that Drp1 functions downstream of Bax during apoptosis.”
From New insights into the role of mitochondria in aging: mitochondrial dynamics and more (2010) · cites this paper as Brooks et al., 2009
In the citing paper
“The role of mitochondrial dynamics in regulating apoptosis is mainly based on the finding that overexpression of the dominant-negative mutant Drp1K38A induces mitochondrial fusion and confers resistance to apoptosis by preventing a loss of Δψm and inhibiting cytochrome c release (Breckenridge et al., 2003; Brooks et al., 2009; Frank et al., 2001; Karbowski et al., 2002).”
From New insights into the role of mitochondria in aging: mitochondrial dynamics and more (2010) · cites this paper as Brooks et al., 2009
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Citations
Cites
The BCL-2 protein family: opposing activities that mediate cell death
Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,806
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
(2001) · PubMed · Cited by 2,381
Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
Pabla, N., & Dong, Z. (2008) · Kidney International · doi:10.1038/sj.ki.5002786 · Cited by 1,959
Self-citationDynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells
Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938
Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376
Mitochondrial dynamics and apoptosis
Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270
Cassidy-Stone, A., Chipuk, J. E., Ingerman, E., Song, C., Yoo, C., Kuwana, T., Kurth, M. J., Shaw, J. T., Hinshaw, J. E., Green, D. R., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.019 · Cited by 1,200
Cribbs, J. T., & Strack, S. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401062 · Cited by 1,061
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
Lee, Y.-J., Jeong, S.-Y., Karbowski, M., Smith, C. L., & Youle, R. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0294 · Cited by 1,042
Research works printed but not linked: 1
- Wang, 2001, Genes Dev., 15, 2922
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Items 601–700 of 735
Gao, X., Han, L., Yao, X., & Ma, L. (2021) · International Urology and Nephrology · doi:10.1007/s11255-021-03010-6 · Cited by 7
Liao, Y.-J., Ma, Y.-X., Huang, L., Zhang, Z., Tan, F., Deng, L., Cao, D., Zeng, X., Yu, G., & Liao, X. (2022) · Bioengineered · doi:10.1080/21655979.2022.2037248 · Cited by 7
Liu, H., & Shen, Y. (2023) · Transplantation · doi:10.1097/tp.0000000000004514 · Cited by 8
Preserving Mitochondrial Structure and Motility Promotes Recovery of White Matter After Ischemia
Bastian, C., Day, J., Politano, S. F., Quinn, J. P., Brunet, S., & Baltan, S. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08550-w · Cited by 7
Kidney Injury in a Hemodilution Model of Hemorrhagic Shock and Fluid Resuscitation
Wang, L., Pei, F., Wu, J., Ouyang, B., & Guan, X. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.06.002 · Cited by 7
Jin, C., Wei, X., Liu, Q., Han, J., Luo, R., Feng, J., Liu, J., Guo, T., Peng, X., & Hu, T. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112350 · Cited by 7
Pharmacological Induction of Kidney Regeneration
Gagliardini, E., Benigni, A., & Perico, N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801734-0.00074-6 · Cited by 7
Chatterjee, T., & Zarjou, A. (2025) · Advances in Kidney Disease and Health · doi:10.1053/j.akdh.2024.12.004 · Cited by 6
Reprogramming mitochondrial homeostasis in renal ischemia–reperfusion injury
Wang, K., Wang, H., Zhang, Y., Zhang, Z., Wang, L., Yang, J., Man, J., & Yang, L. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112294 · Cited by 6
Wu, S., Zhao, X., Wu, M., Yang, L., Liu, X., Li, D., Xu, H., Zhao, Y., Su, X., Wei, Z., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710145 · Cited by 6
Mitochondrial quality control in acute kidney disease
Sheng, J., Li, X., Lei, J., Gan, W., & Song, J. (2023) · Journal of Nephrology · doi:10.1007/s40620-023-01582-3 · Cited by 6
Current therapeutic strategies for acute kidney injury
Negi, S., Wada, T., Matsumoto, N., Muratsu, J., & Shigematsu, T. (2023) · Renal Replacement Therapy · doi:10.1186/s41100-023-00502-2 · Cited by 8
Liu, Y., Xu, Y., Ji, H., Gao, F., Ge, R., Zhou, D., Fu, H., Liu, X., & Ma, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011277 · Cited by 6
Yang, Y., Li, C., Gu, X., Zhen, J., Zhu, S., Lv, T., Wan, Q., & Liu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.700195 · Cited by 6
Choi, Y., Cho, J., Kim, J., Bae, J. H., Cho, E., Chang, E., Joa, K., Kim, J., Park, D., Kang, J., et al. (2022) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002032 · Cited by 7
Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report
Ariga, M., Hagita, J., Soda, M., Oida, Y., Teramachi, H., & Kitaichi, K. (2023) · Journal of Medical Case Reports · doi:10.1186/s13256-023-04136-0 · Cited by 6
Paradis, S., Charles, A., Giannini, M., Meyer, A., Lejay, A., Talha, S., LAVERNY, G., Charloux, A., & Gény, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074025 · Cited by 6
The role of mtDNA damage in mitochondrial dysfunction
Furda, A. M. (2011) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 6
The Role of Sirt3 in Kidney Health and Disease
Azzouz, R. S., & Yan, L. (2025) · Pharmaceuticals · doi:10.3390/ph18111668 · Cited by 4
Su, J., Wu, L., Zeng, C., Zhu, H., Wang, H., He, X., Liang, B., & Cai, J. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.03.029 · Cited by 5
Venoarterial Extracorporeal Membrane Oxygenation Implementation in Septic Shock Rat Model
Wang, T., Zhang, M., Dong, W., Wang, J., Zhang, H., Wang, Y., & Ji, B. (2024) · ASAIO Journal · doi:10.1097/mat.0000000000002168 · Cited by 5
Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury
Moronge, D., Godley, H., Ayulo, V., Mellott, E., Elgazzaz, M., Cooper, G., Mohamed, R., Ogbi, S. N., Gillis, E., Faulkner, J., et al. (2025) · Clinical Science · doi:10.1042/cs20241851 · Cited by 5
Zeng, Z., Han, L., Dong, D., Tang, H., Gao, Z., Hu, S., Zhu, B., Zhang, S., Shu, Y., & Yu, Y. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.05.011 · Cited by 5
Zhang, L., Ye, J., & Qiu, C. (2025) · Human Cell · doi:10.1007/s13577-025-01177-z · Cited by 5
Impairment of Mitochondrial Dynamics: A Target For the Treatment of Neurological Disorders?
Su, Y.-C., & Qi, X. (2013) · Future Neurology · doi:10.2217/fnl.13.8 · Cited by 5
Alkhunaizi, A. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.80625 · Cited by 5
Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold
Gutiérrez, S., Morón, M., Griera, M., Sucunza, D., Calleros, L., García‐Jérez, A., Coderch, C., Hermoso-Pinilla, F. J., Burgos, C., Rodrı́guez-Puyol, M., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.045 · Cited by 5
Early prediction of acute kidney injury in children: known biomarkers but novel combination
Lin, Q., & Mao, J. (2018) · World Journal of Pediatrics · doi:10.1007/s12519-018-0180-4 · Cited by 5
Wang, W., Luo, J., Chen, Y., Liang, H., Li, Z., Chen, Y., He, J., & Liang, X. (2025) · Kidney Diseases · doi:10.1159/000545851 · Cited by 4
Chen, G., Zhou, Y., Lin, M., Li, A., Lü, S., Li, J., Xiao, L., & Hong, X. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117444 · Cited by 4
Choi, D. H., Lee, S. M., Park, B. N., Lee, M. H., Yang, D. E., Son, Y. K., Kim, S. E., & An, W. S. (2024) · Biomedicines · doi:10.3390/biomedicines12092107 · Cited by 4
Research Hotspots in Mitochondria-Related Studies for AKI Treatment: A Bibliometric Study
Yang, M., Huang, Y., Tang, A., Zhang, Y., Liu, Y., Fan, Z., & Li, M. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s473426 · Cited by 4
Unraveling the Pathogenesis of Calcinosis in Systemic Sclerosis: A Molecular and Clinical Insight
Güler, A. A., Luca, G. D. D., Dagna, L., Matucci‐Cerinic, M., & Campochiaro, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011257 · Cited by 4
Zou, B., Wang, D., Zhong, J., He, Z., Zhou, Y., Yang, H., Liu, Y., Zeng, G., & Duan, X. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123608 · Cited by 4
Bonaterra, G. A., Wakenhut, F., Röthlein, D., Wolf, M., Bistrian, B. R., Driscoll, D. F., & Kinscherf, R. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.10.011 · Cited by 4
Gain of ‘FAOnction’, Loss of Fibrosis
Nicholson, R. J., Ramkumar, N., & Summers, S. A. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.03.005 · Cited by 4
Chien, M., Li, S., Wong, S.-C., Chiang, C.-H., Lin, Y., Mersmann, H. J., & Chen, C. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1949022 · Cited by 4
Yang, Q., Hu, J., Ning, Y., Zhao, S., Chen, W., Ren, T., Zhang, D., Ding, X., & Zou, J. (2023) · Shock · doi:10.1097/shk.0000000000002125 · Cited by 5
STUDY OF THE CHEMISTRY OF MODIFIED SILICA SURFACE BY DYE ADSORPTION
Khokhlova, T. D., Nikitin, Y. S., & Detistova, A. L. (1991) · Russian Journal of Physical Chemistry A · Cited by 4
Pandya, R. D., Lackner, E. M., Xu, C. S., Zugates, C. T., Burdyniuk, M., Reyna‐Neyra, A., Pandya, V. D., Li, W., Pang, S., Weisz, O. A., et al. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000884 · Cited by 3
PSTK exerts protective role in cisplatin‐tubular cell injury via BAX/BCL2/Caspase3 pathway
Wu, Y., Xv, Y., Zhao, L., Zhou, Z., Wang, M., Xi, J., Liming, Y., Gao, J., Deng, B., & Dong, Z. (2025) · Physiological Reports · doi:10.14814/phy2.70162 · Cited by 3
Self-citationRyu, J., Yu, J. O., Kim, K., Jeong, E.-J., Kim, M. Y., Yun, H. G., Song, E. B., Kim, J. S., Noh, Y., & Choo, Y. (2025) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2025.110730 · Cited by 3
Yao, Y., Jia, W., Zeng, X., Wang, Y., Hu, Q., Yu, S., He, D., & Li, Y. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4388919 · Cited by 3
Oka, S., Takii, R., Fujimoto, M., Nakai, A., & Shiraishi, K. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112391 · Cited by 3
Gunay, Y., Altaner, Ş., & Ekmen, N. (2014) · Gastroenterology Research and Practice · doi:10.1155/2014/564949 · Cited by 3
Sanz, A. B., Sánchez-Niño, M. D., Ramos, A. M., & Ortíz, A. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch10 · Cited by 3
Mitochondrial Dysfunction in Renal Aging: A Vicious Cycle Driving Kidney Disease Progression
Yu, W., Ouyang, Q., Liu, W., Jia, L., & Wang, B. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864251410936 · Cited by 3
Liu, H., huang, S., Chen, S., Liang, S., Huang, M., Li, S., Xu, Y., & Xie, B. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1725842 · Cited by 3
Phoolmala, Tiwari, S., Yadav, R. K., Chauhan, S. S., & Chaturvedi, R. K. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111375 · Cited by 3
Naya, Y., Hata, N., Kobayash, M., Thuyuki, M., Koyama, Y., & OGIHARA, K. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102188 · Cited by 2
USP13 inhibition exacerbates mitochondrial dysfunction and acute kidney injury by acting on MCL-1
Wang, Q., Cao, S., Sun, Z., Zhu, W., Sun, L., Li, Y., Luo, D., Huang, S., Zhang, Y., Xia, W., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167599 · Cited by 2
Duan, W., Wu, W., Cui, Y., Zhang, M., Li, X., Tian, W., Yang, C., & Zhang, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1619339 · Cited by 2
Mechanisms of Toxicant-Induced Acute Kidney Injury
Lash, L. H., & Cummings, B. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64109-0 · Cited by 2
Protein Kinases and Regulation of Mitochondrial Function in Ischemia/Reperfusion Injury
Nowak, G. (2018) · InTech eBooks · doi:10.5772/intechopen.71094 · Cited by 2
Anderson, E. M., Zhang, J., Russell, G. B., Bowline, I. G., Thyagarajan, B., Li, D., Ma, L., Anderson, E., & Murea, M. (2018) · Kidney International Reports · doi:10.1016/j.ekir.2018.10.021 · Cited by 3
Effects of power frequency electric field exposure on kidney
Di, G., Li, D., Xie, Z., Xu, Y., & Xiang, J. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110354 · Cited by 2
van Furth, L. A., Venema, L. H., Hendriks, K. D. W., Vogelaar, P. C., Krenning, G., & Leuvenink, H. G. D. (2021) · Transplantology · doi:10.3390/transplantology2030031 · Cited by 2
Zonov, E., Игоревна, В. Е., Аркадьевна, З. М., Ageeva, T. A., & Ryabchikova, E. I. (2013) · PubMed · Cited by 2
Mitochondria as the memory of preconditioning.
Zerimech, S., Nguyen, H., & Baltan, S. (2021) · PubMed · Cited by 2
Renal Toxicology/Nephrotoxicity of Cisplatin and Other Chemotherapeutic Agents
Dupre, T. V., Sharp, C. N., & Siskind, L. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64183-1 · Cited by 3
Regulatory roles of hypoxia-inducible, noncoding RNAs on mitochondrial dynamics during AKI
Tanaka, T., & Nangaku, M. (2019) · Kidney International · doi:10.1016/j.kint.2018.12.002 · Cited by 2
Wang, S., Zheng, J., Zhang, X., Zhao, M., Li, J., Su, M., & Qiu, W. (2025) · The FASEB Journal · doi:10.1096/fj.202402401rr · Cited by 1
Therapeutic Approaches Involving Mitochondria in the Treatment of Acute Kidney Injury
Patel, P. S., Pabla, N., & Bajwa, A. (2025) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2025.151676 · Cited by 1
Shah, R., Varghese, R., Anchan, H., Pai, S., Zagade, T., Oswal, M., Agarwal, S., Sood, P., Digholkar, G., Deshpande, A., et al. (2025) · Drug Development Research · doi:10.1002/ddr.70188 · Cited by 2
Zaroon, Z., D’Ambrosio, C., & de Nigris, F. (2026) · Biomolecules · doi:10.3390/biom16010120 · Cited by 1
Al-Somat, M. A., Al-Mahbashi, H. M., & Al-Nabehi, A. S. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119187 · Cited by 1
Mitochondria: The Crossroads of Complement Activation and Kidney Injury Progression
McGraw, M. K., & Parajuli, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125599 · Cited by 1
Mitochondrial redox imbalance in triggering regulated cell death in kidney diseases
Zhu, W., Zou, R., Liu, R., Jia, Z., Zhang, Y., & Wu, M. (2026) · iScience · doi:10.1016/j.isci.2026.116405 · Cited by 2
CARDIOPROTECTION BY PRE- AND POST-CONDITIONING: IMPLICATIONS FOR THE ROLE OF MITOCHONDRIA
Camara, A., Aldakkak, M., Bienengraeber, M., & Stowe, D. F. (2011) · University of Zagreb University Computing Centre (SRCE) · Cited by 1
The Inflammatory Response to Ischemic Acute Renal Injury
Lu, C. Y. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00088-4 · Cited by 2
Mitochondrial dysfunction in kidney diseases
Galvan, D. L., & Perico, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00005-x · Cited by 1
Cañizares, S., Guaillas, A., Velarde, F., de Vaca, V. C., Terán, F., & Caicedo, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106488 · Cited by 1
Prem, P. N., Chellappan, D. R., & Kurian, G. A. (2023) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-023-09974-7 · Cited by 1
Chang, C., Wu, J., Zhang, J., & Zhu, Y. (2010) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb10.1297 · Cited by 1
Land, W. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-53868-2_9 · Cited by 1
CHARACTERIZATION OF MITOCHONDRIAL MEMBRANE PROTEINS AS NOVEL COMPONENTS IN MITOCHONDRIAL DYNAMICS
Liu, T. (2014) · Figshare
Isaka, Y., Kimura, T., Takahashi, A., & Takabatake, Y. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801033-4.00016-3
RETRACTED: Sepsis-associated acute kidney injury
Prasad, N., & Gupta, S. S. (2012) · Clinical Queries Nephrology · doi:10.1016/s2211-9477(11)70001-2
RetractedDrp1 ablation in the adult mouse forebrain
Oettinghaus, B. (2014) · edoc (University of Basel) · doi:10.5451/unibas-006288258
Drp1 ablation in the adult mouse forebrain
Fakultät, P.-N. (2014)
Mitochondrial Fission/Fusion and Disease
Higgins, G. C., & Coughlan, M. T. (2016) · Wiley eBooks · doi:10.1002/9780470015902.a0021879
Rapamycin Ameliorates Renal Ischemia/ Reperfusion Injury via Remodeling Immune Microenvironment
Zhang, C., Wang, L., Zhang, Y., Yang, C., & Rong, R. (2015) · SM Journal of Urology · doi:10.36876/smju.1010
Wei, Q., Hill, W., Su, Y., Huang, S., & Dong, Z. (2016)
Self-citationMesenchymal Stromal Cells for Acute Renal Injury
Rota, C., Toya, S., & Morigi, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801734-0.00079-5
[Screening of mitochondrial DNA damage repair genes in rats with septic acute kidney injury].
Yang, J., Wu, F., Chen, J., & Yang, Y. (2018) · PubMed Central · doi:10.3785/j.issn.1008-9292.2018.02.06
Maladaptive Repair and Progression to CKD
Grandaliano, G., Castellano, G., & Gesualdo, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44942-7.00029-7
Emerging Therapies: What’s on the Horizon?
Redahan, L., & Murray, P. T. (2018) · Springer eBooks · doi:10.1007/978-1-4939-8628-6_21
Predisposing factors of kidney function recovery after postrenal obstruction
Jufriady Ismy, X., Husen, L. D. S., & Hidayat, I. (2019) · Bali Medical Journal · doi:10.15562/bmj.v8i3.1616
Mechanisms of Kidney and Heart Cross-talk in Acute Kidney Injury
Pourafshar, N., & Okusa, M. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-57460-4_18
Sirtuins as key players in aging and kidney dysfunction
Perico, L., & Benigni, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00013-6
Progression of kidney disease as a maladaptive response to injury
Li, X., Ding, F., Lee, K., & He, C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823318-4.00033-0
Identifying Novel Therapies to Reduce Injury following Ischemia Reperfusion in Kidney
Reid, S. (2021) · TSpace (University of Toronto)
Wang, X., Wang, Y., Zhou, G., Li, Y., Huo, H., Liang, F., Xue, J., Shi, X., Yin, A., Xiao, Q., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1031344/v1
Mutagenesis and Mitochondrial-Associated Pathologies
Fasullo, M., & Catalá, Á. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98146
Mitochondrial Cytopathies of the Renal System
Nigam, L. K., Vanikar, A. V., Patel, R., Kanodia, K. V., Suthar, K. S., & Thakkar, U. G. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.96850
Pharmacological Interventions in Acute Kidney Injury
Chopra, T., Balogun, R. A., & Okusa, M. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-52978-5.00048-3
Varrier, M., Forni, L. G., & Ostermann, M. (2015) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-319-13761-2_28
Liu, H., & Ye, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.25.497584
Metadata
- Authors
- Brooks, C., Wei, Q., Cho, S.-G., & Dong, Z.
- Affiliations
- Charlie Norwood VA Medical Center (US)
- Corresponding author
- Dong, Zheng
- Venue
- Journal of Clinical Investigation
- Published
- 2009-05-01
- Volume
- 119
- Issue
- 5
- Pages
- 1275-1285
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2673870
- OpenAlex
- W2155978870
- Cited by
- 735
- References
- 58
- Citations by year
- 2026: 24 · 2025: 31 · 2024: 51 · 2023: 34 · 2022: 59 · 2021: 49 · 2020: 64 · 2019: 59 · 2018: 43 · 2017: 54 · 2016: 42 · 2015: 40 · 2014: 45 · 2013: 36 · 2012: 41
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Brigham and Women's Hospital
- Silence Therapeutics
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial dynamics, mitochondrial fragmentation, acute kidney injury, apoptosis, mitochondrial outer membrane permeabilization, cytochrome c release, Drp1, Mdivi-1, renal ischemia-reperfusion, cisplatin nephrotoxicity, Bcl-2, caspase activation, ATP depletion
- MeSH terms
- Adenosine Triphosphate, Animals, Cell Line, Cells, Cultured, Cisplatin, Enzyme Inhibitors, Kidney Tubular Necrosis, Acute, Kidney Tubules, Proximal, Male, Mice, Inbred C57BL, Microtubule-Associated Proteins, Mitochondria, Reperfusion Injury, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Sodium Azide, GTP Phosphohydrolases, Imaging, Three-Dimensional, Dynamins, RNA, Small Interfering, Cytochromes c, Mice, Rats, Caspase Inhibitors
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