The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
Open accessAbstract
Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that delta(9)-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2alpha (eIF2alpha) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3-dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
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Cites
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Metadata
- Authors
- Salazar, M., Carracedo, A., Salanueva, Í. J., Hernández-Tiedra, S., Lorente, M., Egia, A., Vázquez, P., Blázquez, C., Torres, S., García, S., Nowak, J., Fimia, G. M., Piacentini, M., Cecconi, F., Pandolfi, P. P., González-Feria, L., Iovanna, J. L., Guzmán, M., Boya, P., & Velasco, G.
- Venue
- Journal of Clinical Investigation
- Published
- 2009-05-01
- Volume
- 119
- Issue
- 5
- Pages
- 1359-1372
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2134197723
- Cited by
- 686
- References
- 37
- FWCI
- 28.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Salazar, M., Carracedo, A., Salanueva, Í. J., Hernández-Tiedra, S., Lorente, M., Egia, A., Vázquez, P., Blázquez, C., Torres, S., García, S., Nowak, J., Fimia, G. M., Piacentini, M., Cecconi, F., Pandolfi, P. P., González-Feria, L., Iovanna, J. L., Guzmán, M., Boya, P., & Velasco, G. (2009). Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. Journal of Clinical Investigation. https://doi.org/10.1172/jci37948
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
