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The key role of vitamin A in spermatogenesis
Open accessAbstract
Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. Vertebrate testes are arranged into recurring cellular associations that vary with time and distance along the tubule. These changes over time and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, respectively. In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave.
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Citations
Cited by
Spermatogenesis: The Commitment to Meiosis
Griswold, M. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00013.2015 · Cited by 825
Self-citationVitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
“Recent work supports the conclusion that the vitamin A metabolite, RA, is needed both for adult male spermatogonial differentiation (transition to A1) and the entrance into meiosis [45–47].”
BackgroundResultRetinoic acid synthesis and functions in early embryonic development
Kin Ting Kam, R., Deng, Y., Chen, Y., & Zhao, H. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-11 · Cited by 283
The Vitamin A–Redox Hypothesis: A Biochemical Basis for Honest Signaling via Carotenoid Pigmentation
Hill, G. E., & Johnson, J. D. (2012) · The American Naturalist · doi:10.1086/667861 · Cited by 174
Transport of vitamin A across blood‐tissue barriers is facilitated by STRA6
Kelly, M., Widjaja‐Adhi, M. A. K., Palczewski, G., & von Lintig, J. (2016) · The FASEB Journal · doi:10.1096/fj.201600446r · Cited by 60
Metadata
- Authors
- Hogarth, C. A., & Griswold, M. D.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-04-01
- Volume
- 120
- Issue
- 4
- Pages
- 956-962
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2112964867
- Cited by
- 279
- References
- 0
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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