The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Angiotensin II sustains brain inflammation in mice via TGF-β
Open accessAbstract
The renin-angiotensin-aldosterone system (RAAS) is a key hormonal system regulating blood pressure. However, expression of RAAS components has recently been detected in immune cells, and the RAAS has been implicated in several mouse models of autoimmune disease. Here, we have identified Ang II as a paracrine mediator, sustaining inflammation in the CNS in the EAE mouse model of MS via TGF-beta. Ang II type 1 receptors (AT1Rs) were found to be primarily expressed in CNS-resident cells during EAE. In vitro, astrocytes and microglia responded to Ang II treatment by inducing TGF-beta expression via a pathway involving the TGF-beta-activating protease thrombospondin-1 (TSP-1). TGF-beta upregulation in astrocytes and microglia during EAE was blocked with candesartan (CA), an inhibitor of AT1R. Treatment of EAE with CA ameliorated paralysis and blunted lymphocyte infiltration into the CNS, outcomes that were also seen with genetic ablation of AT1Ra and treatment with an inhibitor of TSP-1. These data suggest that AT1R antagonists, frequently prescribed as antihypertensives, may be useful to interrupt this proinflammatory, CNS-specific pathway in individuals with MS.
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Nabah, Y. N. A., Mateo, T., Estellés, R., Mata, M., Zagorski, J., Sarau, H., Cortijo, J., Morcillo, E. J., Jose, P. J., & Sanz, M.-J. (2004) · Circulation · doi:10.1161/01.cir.0000148824.93600.f3 · Cited by 124
Sagawa, K., Nagatani, K., Komagata, Y., & Yamamoto, K. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21040 · Cited by 83
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Luo, Y., Zhao, X., Zhou, J., Yang, J., Zhang, Y., Kuang, W., Peng, J., Chen, L., & Zeng, J. (2017) · Nature Communications · doi:10.1038/s41467-017-00680-8 · Cited by 916
COVID-19 cytokine storm: the anger of inflammation
Mahmudpour, M., Roozbeh, J., Keshavarz, M., Farrokhi, S., & Nabipour, I. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155151 · Cited by 461
“For example, Ang II as an element from ACE/Ang II/AT1R induces TGFβ expression [22,117].”
Transforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation
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Metadata
- Authors
- Lanz, T. V., Ding, Z., Ho, P. P., Luo, J., Agrawal, A. N., Srinagesh, H., Axtell, R., Zhang, H., Platten, M., Wyss-Coray, T., & Steinman, L.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-08-02
- Volume
- 120
- Issue
- 8
- Pages
- 2782-2794
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2064623974
- Cited by
- 198
- References
- 2
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Lanz, T. V., Ding, Z., Ho, P. P., Luo, J., Agrawal, A. N., Srinagesh, H., Axtell, R., Zhang, H., Platten, M., Wyss-Coray, T., & Steinman, L. (2010). Angiotensin II sustains brain inflammation in mice via TGF-β. Journal of Clinical Investigation. https://doi.org/10.1172/jci41709
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