Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Integrins in cancer: biological implications and therapeutic opportunities

Desgrosellier, J. S., & Cheresh, D. A. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2748 · Cited by 3,815

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,512

Angiopoietin-2 Is Required for Postnatal Angiogenesis and Lymphatic Patterning, and Only the Latter Role Is Rescued by Angiopoietin-1

Gale, N. W., Thurston, G., Hackett, S. F., Renard, R. A., Wang, Q., McClain, J., Martin, C., Witte, C. L., Witte, M. H., Jackson, D. G., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00217-4 · Cited by 1,017

Random versus directionally persistent cell migration

Petrie, R. J., Doyle, A. D., & Yamada, K. M. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2729 · Cited by 995

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., & Breitman, M. L. (1994) · Genes & Development · doi:10.1101/gad.8.16.1897 · Cited by 985

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine · doi:10.1038/nm1351 · Cited by 933

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

Mazzieri, R., Pucci, F., Moi, D., Zonari, E., Ranghetti, A., Berti, A., Politi, L. S., Gentner, B., Brown, J. L., Naldini, L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.005 · Cited by 639

Angiogenesis and Microvascular PermeabilityPreprint

Zeng, Y., & Fu, B. M. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041163 · Cited by 28

Unravelling the Glioblastoma Tumour Microenvironment: Can Aptamer Targeted Delivery Become Successful in Treating Brain Cancers?

Giles, B., Nakhjavani, M., Wiesa, A., Knight, T., Shigdar, S. L., & Samarasinghe, R. M. (2023) · Cancers · doi:10.3390/cancers15174376 · Cited by 27

miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2

Sifeng, T., Wang, D., Zhang, Q., & Li, L. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3893 · Cited by 27

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

Schillemans, M., Kat, M., Westeneng, J., Gangaev, A., Hofman, M., Nota, B., van Alphen, F. P. J., de Boer, M., van den Biggelaar, M., Margadant, C., et al. (2019) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12242 · Cited by 26

Endothelium-specific deletion of Nox4 delays retinal vascular development and mitigates pathological angiogenesis

Tang, X., Wang, J. J., Wang, J., Abboud, H. E., Chen, Y., & Zhang, S. X. (2020) · Angiogenesis · doi:10.1007/s10456-020-09757-3 · Cited by 26

Platelet-Rich Plasma Extract Prevents Pulmonary Edema through Angiopoietin-Tie2 Signaling

Mammoto, T., Jiang, A. R., Jiang, E., & Mammoto, A. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0076oc · Cited by 27

The Interplay between Cofilin and Phospho-Cofilin: Its Role in Maintaining Blood Brain Barrier Integrity

Alhadidi, Q., Sayeed, M. S. B., & Shah, Z. A. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527316666170117115040 · Cited by 27

Influence of traumatic brain injury on extracellular tau elimination at the blood–brain barrier

Eisenbaum, M., Pearson, A., Gratkowski, A., Mouzon, B., MULLAN, M. J., Crawford, F., Ojo, J. O., & Bachmeier, C. J. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00283-y · Cited by 26

Epigenetic modulators mitigate angiogenesis through a complex transcriptomic network

Shankar, T. V. S., & Willems, L. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.01.003 · Cited by 25

Angiogenesis and autosomal dominant polycystic kidney disease

Huang, J. L., Woolf, A. S., & Long, D. A. (2012) · Pediatric Nephrology · doi:10.1007/s00467-012-2305-7 · Cited by 25

The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration

Wang, K., Liu, W., Song, Y., Wu, X., Zhang, Y., Li, S., Gao, Y., Tu, J., Liu, Y., & Cao, Y. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.35 · Cited by 25

ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia

Zhou, X., Pucel, J. C., Nomura-Kitabayashi, A., Chandakkar, P., Bartoletti, A. P., Jhangiani, N. L., Bao, D., Fan, J., Arthur, H. M., Ullmer, C., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319385 · Cited by 24

Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development

Thapa, K., Khan, H., Kaur, G., Kumar, P., & Singh, T. G. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149130 · Cited by 27

Bone marrow-derived mesenchymal stromal cells improve vascular regeneration and reduce leukocyte-endothelium activation in critical ischemic murine skin in a dose-dependent manner

Schweizer, R., Kamat, P., Schweizer, D., Dennler, C., Zhang, S., Schnider, J. T., Salemi, S., Giovanoli, P., Eberli, D., Enzmann, V., et al. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.05.008 · Cited by 24

Differential regulation of angiopoietin 1 and angiopoietin 2 during dengue virus infection of human umbilical vein endothelial cells: implications for endothelial hyperpermeability

Ong, S. P., Ng, M. L., & Chu, J. J. H. (2013) · Medical Microbiology and Immunology · doi:10.1007/s00430-013-0310-5 · Cited by 24

Endothelial dysfunction in von Willebrand disease: angiogenesis and angiodysplasia

RANDI, A. M. (2016) · Thrombosis Research · doi:10.1016/s0049-3848(16)30366-8 · Cited by 23

Angiogenic activity of endothelial progenitor cells through angiopoietin-1 and angiopoietin-2

Siavashi, V., Sariri, R., Nassiri, S. M., Esmaeilivand, M., Asadian, S., Cheraghi, H., Barekati‐Mowahed, M., & Rahbarghazi‬, R. (2016) · Animal Cells and Systems · doi:10.1080/19768354.2016.1189961 · Cited by 23

ARID1A knockdown in human endothelial cells directly induces angiogenesis by regulating angiopoietin-2 secretion and endothelial cell activity

Yoodee, S., Peerapen, P., Plumworasawat, S., & Thongboonkerd, V. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.218 · Cited by 23

Bleeding in continuous flow left ventricular assist device recipients: an acquired vasculopathy?

Patel, S. R., Vukelic, S., & Jorde, U. P. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.10.81 · Cited by 23

2-Chlorofatty acids induce Weibel-Palade body mobilization

Hartman, C. L., Duerr, M. A., Albert, C. J., Neumann, W. L., McHowat, J., & Ford, D. A. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m080200 · Cited by 23

Regulation of Angiogenic Functions by Angiopoietins through Calcium-Dependent Signaling Pathways

Pafumi, I., Favia, A., Gambara, G., Papacci, F., Ziparo, E., Palombi, F., & Filippini, A. (2015) · BioMed Research International · doi:10.1155/2015/965271 · Cited by 23

Prorenin stimulates a pro‐angiogenic and pro‐inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia

Zhu, T., Miller, A. G., Deliyanti, D., Berka, D., Agrotis, A., Campbell, D. J., & Wilkinson‐Berka, J. L. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12376 · Cited by 23

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease

Castanho, I., Yeganeh, P. N., Boix, C. A., Morgan, S. L., Mathys, H., Prokopenko, D., White, B., Soto, L. M., Pegoraro, G., Shah, S. A., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00892-3 · Cited by 22

Exercise training regulates angiogenic gene expression in white adipose tissue

Lee, H. J. (2018) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1836010.005 · Cited by 22

Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody

Singhal, M., Gengenbacher, N., Porta, S. L., Gehrs, S., Shi, J., Kamiyama, M., Bodenmiller, D. M., Fischl, A. S., Schieb, B., Besemfelder, E., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911164 · Cited by 24

The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis

Yamada, Y., Zhong, Y., Miki, S., Taura, A., & Rabbitts, T. H. (2022) · Scientific Reports · doi:10.1038/s41598-022-11297-3 · Cited by 22

The Chemokine CCL4 Stimulates Angiopoietin-2 Expression and Angiogenesis via the MEK/ERK/STAT3 Pathway in Oral Squamous Cell Carcinoma

Lu, C.-C., Tsai, H., Yang, D., Wang, S., Tsai, M., Hua, C., Chen, K., Chen, M. Y., Lien, M., & Tang, C. (2022) · Biomedicines · doi:10.3390/biomedicines10071612 · Cited by 21

T7 peptide inhibits angiogenesis via downregulation of angiopoietin-2 and autophagy

WANG, F., Dong, X., Xiu, P., Zhong, J., Wei, H., Xu, Z., Li, T., Liu, F., Sun, X., & Li, J. (2014) · Oncology Reports · doi:10.3892/or.2014.3653 · Cited by 21

Molecular Understanding of Growth Inhibitory Effect from Irradiated to Bystander Tumor Cells in Mouse Fibrosarcoma Tumor Model

Desai, S., Nishad, S., Yadav, H. D., Shetake, N. G., Balla, M. M. S., Kumar, A., Ray, P., Ghosh, A., & Pandey, B. N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161662 · Cited by 21

Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

Grant, Z. L., Whitehead, L. W., Wong, V. H. Y., He, Z., Yan, R. Y., Miles, A. R., Benest, A. V., Bates, D. O., Prahst, C., Bentley, K., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci127668 · Cited by 21

Akt1-dependent expression of angiopoietin 1 and 2 in vascular smooth muscle cells leads to vascular stabilization

Ha, J. M., Jin, S. Y., Lee, H. S., Kum, H. J., Vafaeinik, F., Ha, H. K., Song, S. H., Kim, C. D., & Bae, S. S. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00819-8 · Cited by 21

Angiopoietin-2 Enhances Survival in Experimental Sepsis Induced by Multidrug-Resistant Pseudomonas aeruginosa

Tzepi, I., Giamarellos‐Bourboulis, E. J., Carrer, D.-P., Τσαγανός, Θ., Claus, R. A., Vaki, I., Πελεκάνου, Α., Kotsaki, A., Tziortzioti, V., Topouzis, S., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.195180 · Cited by 20

Novel strategies for targeting neutrophil against myocardial infarction

Jiang, K., Hwa, J., & Xiang, Y. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107256 · Cited by 20

Prognostic Impact of PHIP Copy Number in Melanoma: Linkage to Ulceration

Bezrookove, V., de Semir, D., Nosrati, M., Tong, S., Wu, C., Thummala, S., Dar, A. A., Leong, S. P. L., Cleaver, J. E., Sagebiel, R. W., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.369 · Cited by 20

Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy

Prea, S. M., Chan, E. C., Dusting, G. J., Vingrys, A. J., Bui, B. V., & Liu, G. (2015) · Journal of Ophthalmology · doi:10.1155/2015/201726 · Cited by 21

Cervical cancer cell–derived angiopoietins promote tumor progression

Yang, P., Chen, N., Yang, D., Crane, J. L., Huang, B., Dong, R., Yi, X., Guo, J., Cai, J., & Wang, Z. (2017) · Tumor Biology · doi:10.1177/1010428317711658 · Cited by 20

Levels of Endocan, Angiopoietin-2, and Hypoxia-Inducible Factor-1a in Patients with Autosomal Dominant Polycystic Kidney Disease and Different Levels of Renal Function

Raptis, V., Bakogiannis, C., Loutradis, C., Boutou, A., Lampropoulou, I., Intzevidou, E., Sioulis, A., Balaskas, E. V., & Sarafidis, P. A. (2018) · American Journal of Nephrology · doi:10.1159/000488115 · Cited by 20

Role of the tumor microenvironment in digestive neuroendocrine tumors

Cuny, T., de Herder, W. W., Barlier, A., & Hofland, L. J. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0025 · Cited by 20

Mechanosensitive Pathways Involved in Cardiovascular Development and Homeostasis in Zebrafish

Li, R., Baek, K. I., Chang, C., Zhou, B., & Hsiai, T. K. (2019) · Journal of Vascular Research · doi:10.1159/000501883 · Cited by 20

Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth

Yu, X., Sha, J., Shao, X., Qin, S., Conrad, P., Ghosh, S. K., Weinberg, A., & Ye, F. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1196303 · Cited by 20

The IL ‐4– IL ‐ 4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell

Hara, Y., Jha, M. K., Huang, J. Y., Han, Y., Langohr, I. M., Gaglia, G., Zhu, C., Piepenhagen, P. A., Gayvert, K. M., Lim, W. K., et al. (2024) · Allergy · doi:10.1111/all.16338 · Cited by 19

Angiopoietin-2 regulated by progesterone induces uterine vascular remodeling during pregnancy

Park, Y.-G., Choi, J., & Seol, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11185 · Cited by 19

Direct infection of primary endothelial cells with human cytomegalovirus prevents angiogenesis and migration

Gustafsson, R. K. L., Jeffery, H. C., Yaiw, K.-C., Wilhelmi, V., Kostopoulou, O. N., Davoudi, B., Rahbar, A., Bénard, M., Renné, T., Söderberg‐Nauclér, C., et al. (2015) · Journal of General Virology · doi:10.1099/jgv.0.000301 · Cited by 19

Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth

Chen, L., Zeng, X., Kleibeuker, E. A., Buffa, F. M., Barberis, A., Leek, R., Roxanis, I., Zhang, W., Worth, A. T., Beech, J. S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6981 · Cited by 19

Vanucizumab mode of action: Serial biomarkers in plasma, tumor, and skin-wound-healing biopsies

Heil, F., Babitzki, G., Julien-Laferrière, A., Ooi, C.-H., Hidalgo, M. M., Massard, C., Martinez‐García, M., Tourneau, C. L., Kockx, M. M., Gerber, P. A., et al. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100984 · Cited by 19

Angiopoietin-2 is Vasoprotective in the Acute Phase of Cerebral Ischemia

Marteau, L., Valable, S., Divoux, D., Roussel, S., Touzani, O., MacKenzie, E. T., Bernaudin, M., & Petit, E. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.178 · Cited by 19

Mechanisms of tumour vascularization in cutaneous malignant melanoma: clinical implications

Pastushenko, I., Vermeulen, P. B., den Eynden, G. G. V., Rutten, A., Carapeto, F. J., Dirix, L. Y., & Laere, S. V. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12973 · Cited by 19

Chronic Cerebral Hypoperfusion Induces Alterations of Matrix Metalloproteinase-9 and Angiopoietin-2 Levels in the Rat Hippocampus

Kim, M., Choi, B., Lee, Y. W., Kim, D.-H., Han, Y. S., Jeon, W. K., & Han, J. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.4.299 · Cited by 19

The Succinate Receptor SUCNR1 Resides at the Endoplasmic Reticulum and Relocates to the Plasma Membrane in Hypoxic Conditions

Sanchez, M., Hamel, D., Bajon, E., Duhamel, F., Bhosle, V. K., Zhu, T., Rivera, J. C., Dabouz, R., Nadeau‐Vallée, M., Sitaras, N., et al. (2022) · Cells · doi:10.3390/cells11142185 · Cited by 18

Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH—Results from a prospective discovery and validation biomarker study

Hadinnapola, C., Southwood, M. R., Hernández‐Sánchez, J., Bunclark, K., Newnham, M., Swietlik, E. M., Cannon, J. E., Preston, S., Sheares, K. K. K., Taboada, D., et al. (2022) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2022.08.021 · Cited by 18

Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity

Bhatraju, P. K., Morrell, E. D., Stanaway, I. B., Sathe, N. A., Srivastava, A., Postelnicu, R., Green, R. R., Andrews, A., Gonzalez, M., Kratochvil, C. J., et al. (2022) · Critical Care Explorations · doi:10.1097/cce.0000000000000827 · Cited by 18

Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature

Lim, D. C., Brady, D. C., Soans, R. E., Kim, E., Valverde, L. B., Keenan, B. T., Guo, X., Kim, W. Y., Park, M., Galante, R. J., et al. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01040.2015 · Cited by 18

Anatomic Control with Faricimab versus Aflibercept in the YOSEMITE/RHINE Trials in Diabetic Macular Edema

Lim, J. I., Amador, M. J., Dhoot, D. S., Finn, A. P., Fraser‐Bell, S., Gibson, K., Idowu, O. O., Khurana, R. N., Lanzetta, P., Lin, T.-C., et al. (2025) · Ophthalmology Retina · doi:10.1016/j.oret.2025.01.017 · Cited by 18

Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling

Hou, H., Ning, F., Zhang, J. Y., Lu, Q., Zhang, M., Wu, P., Chen, M., & Lash, G. E. (2021) · Molecular Human Reproduction · doi:10.1093/molehr/gaab014 · Cited by 17

COMP-Ang1: Therapeutic potential of an engineered Angiopoietin-1 variant

Wallace, R. G., Rochfort, K. D., Barabás, P., Curtis, T. M., Uehara, H., Ambati, B. K., & Cummins, P. M. (2021) · Vascular Pharmacology · doi:10.1016/j.vph.2021.106919 · Cited by 17

Short-Term Clinical Outcomes of Patients with Diabetic Macular Edema Following a Therapy Switch to Faricimab

Wolfrum, P., Böhm, E. W., Lorenz, K., Stoffelns, B. M., Pfeiffer, N., & Korb, C. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13154508 · Cited by 17

Differential angiogenic activities of naringin and naringenin in zebrafish in vivo and human umbilical vein endothelial cells in vitro

Chen, L., Yang, B., Tang, B.-Q., Gong, G., Kam, H., Cheng, G., Chen, Y., Wang, R., & Lee, S. M. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.08.010 · Cited by 17

Differential Effects of Ang-2/VEGF-A Inhibiting Antibodies in Combination with Radio- or Chemotherapy in Glioma

Solecki, G. M., Osswald, M., Weber, D., Glock, M., Ratliff, M., Müller, H., Krieter, O., Kienast, Y., Wick, W., & Winkler, F. (2019) · Cancers · doi:10.3390/cancers11030314 · Cited by 18

Trafficking in blood vessel development

Francis, C. R., & Kushner, E. J. (2022) · Angiogenesis · doi:10.1007/s10456-022-09838-5 · Cited by 17

Prognostic value of angiopoietin-2 in non-small cell lung cancer patients: a meta-analysis

Xuan, Z., Zhang, S., Yuan, S., Wang, W., & Yu, J. (2016) · World Journal of Surgical Oncology · doi:10.1186/s12957-016-0992-4 · Cited by 17

Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

Shlamkovich, T., Aharon, L., Koslawsky, D., Einav, Y., & Papo, N. (2018) · BMC Biology · doi:10.1186/s12915-018-0557-9 · Cited by 16

Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors

Pereira, M. T., Gram, A., Nowaczyk, R., Boos, A., Hoffmann, B., Janowski, T. E., & Kowalewski, M. P. (2019) · Reproductive Biology · doi:10.1016/j.repbio.2019.02.001 · Cited by 16

Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds

Tiffany, A. S., Dewey, M. J., & Harley, B. A. C. (2020) · RSC Advances · doi:10.1039/d0ra03872e · Cited by 16

The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Kapiainen, E., Kihlström, M. K., Pietilä, R. S., Kaakinen, M., Ronkainen, V., Tu, H., Heikkinen, A., Devarajan, R., Miinalainen, I., Laitakari, A., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-1904 · Cited by 17

Neuroprotective Effect of Angiopoietin2 Is Associated with Angiogenesis in Mouse Brain Following Ischemic Stroke

Lv, L.-L., Du, Y.-T., Chen, X., Yu, L., & Sun, F. (2022) · Brain Sciences · doi:10.3390/brainsci12111428 · Cited by 16

The TIE Receptor Family

Saharinen, P., Jeltsch, M., Santoyo, M. M., Leppänen, V., & Alitalo, K. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-11888-8_16 · Cited by 18

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes

Shah, P., Lueschen, N., Ardestani, A. D., Oberholzer, J., Olerud, J., Carlsson, P., & Maedler, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161834 · Cited by 18

miR144-3p inhibits PMVECs excessive proliferation in angiogenesis of hepatopulmonary syndrome via Tie2

Yang, C., Lv, K., Chen, B., Yang, Y., Ai, X., Yu, H., Yang, Y., Yi, B., & Lu, K. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.02.009 · Cited by 16

Angiopoietin-2 promotes extracellular matrix degradation in human degenerative nucleus pulposus cells

Wang, K., Kang, L., Liu, W., Song, Y., Wu, X., Zhang, Y., Hua, W., Zhao, K., Li, S., Tu, J., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3576 · Cited by 16

Increased mobilization of mesenchymal stem cells in patients with acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation

Patry, C., Doniga, T., Lenz, F., Viergutz, T., Weiß, C., Tönshoff, B., Kalenka, A., Yard, B. A., Krebs, J., Schaible, T., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227460 · Cited by 16

Angiogenesis within atherosclerotic plaques: Mechanical regulation, molecular mechanism and clinical diagnosis

Chen, H., Peng, C.-Y., Fang, F., Li, Y., Liu, X., Hu, Y., Wang, G., Liu, X., & Shen, Y. (2025) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2025.100114 · Cited by 15

Estrogen-related receptor alpha (ERRα) promotes the migration, invasion and angiogenesis of breast cancer stem cell-like cells

Muduli, K., Pradhan, J., Prusty, M., Samal, A. P., Reddy, K. S., & Elangovan, S. (2024) · Medical Oncology · doi:10.1007/s12032-024-02329-1 · Cited by 15

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Kiesworo, K., Agius, T., MacArthur, M. R., Lambelet, M., Lyon, A., Zhang, J., Turiel, G., Fan, Z., D'Almeida, S. M., Uygun, K., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111656 · Cited by 18

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Suzuki, T., Loyde, E., Chen, S., Etzrodt, V., Idowu, T. O., Clark, A. J., Saadé, M. C., Flores, B. M., Lu, S., Birrane, G., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci174135 · Cited by 15

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Nada, S. E., Kahaleh, B., & Altorok, N. (2021) · Journal of Scleroderma and Related Disorders · doi:10.1177/23971983211033772 · Cited by 15

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Tumor Angiogenesis

(2019) · Springer eBooks · doi:10.1007/978-3-319-33673-2 · Cited by 15

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Formanowicz, D., Radom, M., Zawierucha, P., & Formanowicz, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173020 · Cited by 14

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Coelho, A., Araújo, A., Gomes, M. P., Catarino, R., Marques, A., & Medeiros, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090009 · Cited by 14

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Yang, X., Shen, F., Hu, W., Coleman, R. L., & Sood, A. K. (2014) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000136 · Cited by 14

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Reiss, Y., Scholz, A., & Plate, K. H. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2907-8_13 · Cited by 14

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Tip Cells in Angiogenesis

Dallinga, M. G., Boas, S. E. M., Klaassen, I., Merks, R. M. H., Noorden, C. J. F. V., & Schlingemann, R. O. (2015) · Wiley eBooks · doi:10.1002/9780470015902.a0025977 · Cited by 14

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Chen, T., Wang, K., & Sun, Z. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5473 · Cited by 13

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Schlosser, K., Taha, M., Deng, Y., McIntyre, L., Mei, S. H. J., & Stewart, D. J. (2017) · Thorax · doi:10.1136/thoraxjnl-2017-210413 · Cited by 14

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Dhillon, J. S., Young, S. A., Sherman, S. E., Bell, G. I., Amsden, B. G., Hess, D. A., & Flynn, L. E. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36573 · Cited by 13

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Kumar, D., Patel, S. A., Khan, R., Chawla, S., Mohapatra, N., & Dixit, M. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-1044 · Cited by 13

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Kim, B., Lee, J., Choi, J., Park, D. Y., Song, H. Y., Park, T. K., Cho, C., Ye, S., Joo, C., Koh, G. Y., et al. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13177 · Cited by 13

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Zheng, Z., Wan, Y., Liu, Y., Yang, Y., Tang, J., Huang, W., & Cheng, B. (2017) · Journal of Diabetes Research · doi:10.1155/2017/7614685 · Cited by 13

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Schlereth, S. L., Karlstetter, M., Hos, D., Matthaei, M., Cursiefen, C., & Heindl, L. M. (2018) · Current Eye Research · doi:10.1080/02713683.2018.1540704 · Cited by 13

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Wang, M., & Zhou, H. J. (2022) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041188 · Cited by 13

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Reinardy, J. L., Corey, D. M., Golzio, C., Mueller, S. B., Katsanis, N., & Kontos, C. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139614 · Cited by 12

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Roy-Luzarraga, M., Abdel-Fatah, T. M. A., Reynolds, L. E., Clear, A. J., Taylor, J. G., Gribben, J. G., Chan, S. Y. T., Jones, J. L., & Hodivala‐Dilke, K. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19304 · Cited by 12

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Cao, B., Zhang, N., Zhang, Y., Fu, Y., & Zhao, D. (2020) · Aging · doi:10.18632/aging.202168 · Cited by 12

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Yadegari, H., Jamil, M. A., Müller, J., Marquardt, N., Rawley, O., Budde, U., El‐Maarri, O., Lillicrap, D., & Oldenburg, J. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005895 · Cited by 12

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Szederjesi, J., Almásy, E., Lazăr, A. E., Huţanu, A., & Georgescu, A. M. (2015) · The Journal of Critical Care Medicine · doi:10.1515/jccm-2015-0004 · Cited by 11

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Yuan, H. T., Khankin, E. V., Karumanchi, S. A., & Parikh, S. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01472-08 · Cited by 383

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Shyu, K. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.09.017 · Cited by 12

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SHIM, W. S. N., Ho, I. A. W., & Wong, P. E. H. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0072 · Cited by 185

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Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2

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