Augustin, Hellmut G.

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister, D., Núñez, N. G., Pinyol, R., Govaere, O., Pinter, M., Szydlowska, M., Gupta, R., Qiu, M., Deczkowska, A., Weiner, A., et al. (2021) · Nature

Cancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and Prognosis

Cited by 1,294

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine

Angiogenesis and VEGF in CancerCell Adhesion Molecules Research

Cited by 933

Angiopoietins: a link between angiogenesis and inflammation

Fiedler, U., & Augustin, H. G. (2006) · Trends in Immunology

Angiogenesis and VEGF in CancerCell Adhesion Molecules Research

Cited by 606

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Felcht, M., Luck, R., Schering, A., Seidel, P., Srivastava, K., Hu, J., Bartol, A., Kienast, Y., Vettel, C., Loos, E. K., et al. (2012) · Journal of Clinical Investigation

Angiogenesis and VEGF in CancerCell Adhesion Molecules Research

Cited by 479

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 398

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Kanasaki, K., Palmsten, K., Sugimoto, H., Ahmad, S., Hamano, Y., Xie, L., Parry, S., Augustin, H. G., Gattone, V. H., Folkman, J., et al. (2008) · Nature

Pregnancy and preeclampsia studiesNeurological Complications and Syndromes

Cited by 381

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

Norrmén, C., Ivanov, K. I., Cheng, J., Zangger, N., Delorenzi, M., Jaquet, M., Miura, N., Puolakkainen, P., Horsley, V., Hu, J., et al. (2009) · Journal of Cell Biology

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 340

Preclinical mouse solid tumour models: status quo, challenges and perspectives

Gengenbacher, N., Singhal, M., & Augustin, H. G. (2017) · Nature Reviews Cancer

Animal testing and alternativesCancer Cells and Metastasis

Cited by 332

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

Park, J.-S., Kim, I.-K., Han, S., Park, I., Kim, C., Bae, J., Oh, S. J., Lee, S., Kim, J. H., Woo, D.-C., et al. (2016) · Cancer Cell

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 327

Amelioration of sepsis by TIE2 activation–induced vascular protection

Han, S., Lee, S.-J., Kim, K. E., Lee, H. S., Oh, N., Park, I., Ko, E., Oh, S. J., Lee, Y.-S., Kim, D., et al. (2016) · Science Translational Medicine

Sepsis Diagnosis and TreatmentAngiogenesis and VEGF in Cancer

Cited by 203

Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy

Kienast, Y., Klein, C., Scheuer, W., Raemsch, R., Lorenzon, E., Bernicke, D., Herting, F., Yu, S., The, H. H., Martarello, L., et al. (2013) · Clinical Cancer Research

Angiogenesis and VEGF in CancerMonoclonal and Polyclonal Antibodies Research

Cited by 201

Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage

Benest, A. V., Kruse, K., Savant, S., Thomas, M., Laib, A. M., Loos, E. K., Fiedler, U., & Augustin, H. G. (2013) · PLoS ONE

Angiogenesis and VEGF in CancerBarrier Structure and Function Studies

Cited by 178

Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth

Srivastava, K., Hu, J., Korn, C., Savant, S., Teichert, M., Kapel, S. S., Jugold, M., Besemfelder, E., Thomas, M., Pasparakis, M., et al. (2014) · Cancer Cell

Angiogenesis and VEGF in CancerCancer Cells and Metastasis

Cited by 140

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

Zheng, W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E. A., Orsenigo, F., Lohela, M., D’Amico, G., Holopainen, T., et al. (2014) · Genes & Development

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 134

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 133

STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

Shen, Y., Wang, X., Liu, Y., Singhal, M., Gürkaşlar, C., Valls, A. F., Lei, Y., Hu, W., Schermann, G., Adler, H., et al. (2021) · Science Signaling

Hippo pathway signaling and YAP/TAZAngiogenesis and VEGF in Cancer

Cited by 121

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice

Leibing, T., Géraud, C., Augustin, I., Boutros, M., Augustin, H. G., Okun, J. G., Langhans, C., Zierow, J., Wohlfeil, S. A., Olsavszky, V., et al. (2018) · Hepatology

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 116

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver

Inverso, D., Shi, J., Lee, K. H., Jakab, M., Ben-Moshe, S., Kulkarni, S. R., Schneider, M., Wang, G., Komeili, M., Vélez, P. A., et al. (2021) · Developmental Cell

Single-cell and spatial transcriptomicsLiver physiology and pathology

Cited by 114

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Korhonen, E. A., Murtomäki, A., Jha, S. K., Anisimov, A., Pink, A., Zhang, Y., Stritt, S., Liaqat, I., Stanczuk, L., Alderfer, L., et al. (2022) · Journal of Clinical Investigation

Lymphatic System and DiseasesAngiogenesis and VEGF in Cancer

Cited by 113

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 108

Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

Thomas, M., Felcht, M., Kruse, K., Kretschmer, S., Deppermann, C., Biesdorf, A., Rohr, K., Benest, A. V., Fiedler, U., & Augustin, H. G. (2010) · Journal of Biological Chemistry

Cell Adhesion Molecules ResearchAngiogenesis and VEGF in Cancer

Cited by 101

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Singhal, M., Gengenbacher, N., Abdul Pari, A. A., Kamiyama, M., Hai, L., Kuhn, B. J., Kallenberg, D. M., Kulkarni, S. R., Camilli, C., Preuß, S. F., et al. (2021) · Science Translational Medicine

Angiogenesis and VEGF in CancerCancer Cells and Metastasis

Cited by 80

Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin‐2 expression in peri‐tumourous liver correlates with increased survival

Géraud, C., Mogler, C., Runge, A., Evdokimov, K., Lu, S., Schledzewski, K., Arnold, B., Hämmerling, G., Koch, P. S., Breuhahn, K., et al. (2013) · Liver International

Angiogenesis and VEGF in CancerHepatocellular Carcinoma Treatment and Prognosis

Cited by 69

Lung endothelium exploits susceptible tumor cell states to instruct metastatic latency

Jakab, M., Lee, K. H., Uvarovskii, A., Ovchinnikova, S., Kulkarni, S. R., Jakab, S., Rostalski, T., Spegg, C., Anders, S., & Augustin, H. G. (2024) · Nature Cancer

Cancer Cells and MetastasisMechanisms of cancer metastasis

Cited by 39