The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms
Open accessAbstract
Spinal cord injury (SCI) often leads to persistent functional deficits due to loss of neurons and glia and to limited axonal regeneration after injury. Here we report that transplantation of human dental pulp stem cells into the completely transected adult rat spinal cord resulted in marked recovery of hind limb locomotor functions. Transplantation of human bone marrow stromal cells or skin-derived fibroblasts led to substantially less recovery of locomotor function. The human dental pulp stem cells exhibited three major neuroregenerative activities. First, they inhibited the SCI-induced apoptosis of neurons, astrocytes, and oligodendrocytes, which improved the preservation of neuronal filaments and myelin sheaths. Second, they promoted the regeneration of transected axons by directly inhibiting multiple axon growth inhibitors, including chondroitin sulfate proteoglycan and myelin-associated glycoprotein, via paracrine mechanisms. Last, they replaced lost cells by differentiating into mature oligodendrocytes under the extreme conditions of SCI. Our data demonstrate that tooth-derived stem cells may provide therapeutic benefits for treating SCI through both cell-autonomous and paracrine neuroregenerative activities.
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Cites
Isolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human Placenta
in 't Anker, P. S., Scherjon, S. A., Kleijburg‐van der Keur, C., de Groot‐Swings, G. M. J. S., Claas, F. H. J., Fibbe, W. E., & Kanhai, H. H. H. (2004) · STEM CELLS · doi:10.1634/stemcells.2004-0058 · Cited by 1,189
STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
Herrmann, J. E., Imura, T., Song, B., Qi, J., Ao, Y., Nguyen, T. K., Korsak, R. A., Takeda, K., Akira, S., & Sofroniew, M. V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1709-08.2008 · Cited by 958
The bright side of the glial scar in CNS repair
Rolls, A., Shechter, R., & Schwartz, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2591 · Cited by 674
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
Yamashita, T., & Tohyama, M. (2003) · Nature Neuroscience · doi:10.1038/nn1045 · Cited by 460
Cited by
Tatullo, M., Marrelli, M., Shakesheff, K. M., & White, L. J. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1899 · Cited by 353
Jarmalavičiūtė, A., Tunaitis, V., Pivoraitė, U., Venalis, A., & Pivoriūnas, A. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2014.07.013 · Cited by 259
Narbute, K., Piļipenko, V., Pupure, J., Dzirkale, Z., Jonavičė, U., Tunaitis, V., Kriaučiūnaitė, K., Jarmalavičiūtė, A., Jansone, B., Kluša, V., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0162 · Cited by 150
Metadata
- Authors
- Sakai, K., Yamamoto, A., Matsubara, K., Nakamura, S., Naruse, M., Yamagata, M., Sakamoto, K., Tauchi, R., Wakao, N., Imagama, S., Hibi, H., Kadomatsu, K., Ishiguro, N., & Ueda, M.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-12-01
- Volume
- 122
- Issue
- 1
- Pages
- 80-90
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2156895150
- Cited by
- 525
- References
- 4
- FWCI
- 14.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sakai, K., Yamamoto, A., Matsubara, K., Nakamura, S., Naruse, M., Yamagata, M., Sakamoto, K., Tauchi, R., Wakao, N., Imagama, S., Hibi, H., Kadomatsu, K., Ishiguro, N., & Ueda, M. (2011). Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. Journal of Clinical Investigation. https://doi.org/10.1172/jci59251
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