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Mechanisms of vancomycin resistance in Staphylococcus aureus
Open accessAbstract
Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive bacterial infections. Traditionally, it has been used as a drug of last resort; however, clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains with decreased susceptibility to vancomycin (vancomycin intermediate-resistant S. aureus [VISA]) and more recently with high-level vancomycin resistance (vancomycin-resistant S. aureus [VRSA]) have been described in the clinical literature. The rare VRSA strains carry transposon Tn1546, acquired from vancomycin-resistant Enterococcus faecalis, which is known to alter cell wall structure and metabolism, but the resistance mechanisms in VISA isolates are less well defined. Herein, we review selected mechanistic aspects of resistance in VISA and summarize biochemical studies on cell wall synthesis in a VRSA strain. Finally, we recapitulate a model that integrates common mechanistic features of VRSA and VISA strains and is consistent with the mode of action of vancomycin.
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“Phenotypically, hVISA/VISA strains exhibit distinct metabolic characteristics that may include i) increase in fructose utilization, ii) increased fatty acid metabolism, iii) impaired acetate metabolism and tricarboxylic acid cycle, iv) decrease in glutamate availability, and iv) increase expression of cell wall synthesis genes.”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [104]
In the citing paper
“However, the available evidence shows that the regulatory systems most consistently implicated in this mechanism of resistance are YycFG (WalKR), VraSR (homolog of LiaFSR), and GraRS (104).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [104]
In the citing paper
“These global homeostatic changes appear to lead to a reduced autolytic activity with thickened cell wall and an increase amount of free D-Ala-D-Ala dipeptides with less peptidoglycan cross-linking (101, 104).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [104]
In the citing paper
“In addition, VISA strains bind vancomycin more avidly than their non –VISA counterparts, however, diffusion of the antibiotic molecule into the inner part of the cell wall appears to be impaired.”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [104]
In the citing paper
“Finally, a striking feature of many hVISA/VISA strains is the ability to revert from one phenotype to another (or even to a fully vancomycin susceptible phenotype) in the absence of vancomycin exposure.”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [104]
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Citations
Cites
Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
Hiramatsu, K. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/40.1.135 · Cited by 1,984
Emergence of Vancomycin Resistance inStaphylococcus aureus
Smith, T. L., Pearson, M. L., Wilcox, K. R., Cruz, C., Lancaster, M. V., Robinson-Dunn, B., Tenover, F. C., Zervos, M., Band, J. D., White, E., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902183400701 · Cited by 1,086
Howden, B. P., Davies, J. K., Johnson, P. D. R., Stinear, T. P., & Grayson, M. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-09 · Cited by 962
Levine, D. P. (2005) · Clinical Infectious Diseases · doi:10.1086/491709 · Cited by 883
Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance
Hiramatsu, K. (2001) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(01)00091-3 · Cited by 761
Genetics and mechanisms of glycopeptide resistance in enterococci
Arthur, M., & Courvalin, P. M. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.8.1563 · Cited by 692
Sieradzki, K., Roberts, R. B., Haber, S. W., & Tomasz, A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902183400704 · Cited by 638
Self-citationMwangi, M. M., Wu, S. W., Zhou, Y., Sieradzki, K., de LENCASTRE, H., Richardson, P., Bruce, D. G., Rubin, E. M., Myers, E. W., Siggia, E. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609839104 · Cited by 538
Self-citationReemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
DeLeo, F. R., & Chambers, H. F. “. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38226 · Cited by 522
Kuroda, M., Kuroda, H., Oshima, T., Takeuchi, F., Mori, H., & Hiramatsu, K. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03599.x · Cited by 515
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Reddy, D. N., & Al‐Rajab, A. J. (2016) · Cogent Chemistry · doi:10.1080/23312009.2016.1220055 · Cited by 49
Guttroff, C., Baykal, A., Wang, H., Popella, P., Kraus, F., Biber, N., Krauss, S., Götz, F., & Plietker, B. J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201707069 · Cited by 47
García, A., Viñuela-Prieto, J. M., González, L. L., & Candel, F. J. (2017) · Infection and Drug Resistance · doi:10.2147/idr.s146748 · Cited by 48
Metabolic Mitigation of Staphylococcus aureus Vancomycin Intermediate-Level Susceptibility
Gardner, S. G., Marshall, D. D., Daum, R. S., Powers, R., & Somerville, G. A. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01608-17 · Cited by 46
Unsuccessful treatment of methicillin-resistant Staphylococcus aureus endocarditis with dalbavancin
Steele, J. M., Seabury, R. W., Hale, C. M., & Mogle, B. T. (2017) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12580 · Cited by 47
Post, S. J., Shapiro, J. A., & Wuest, W. M. (2019) · MedChemComm · doi:10.1039/c9md00032a · Cited by 46
Recent advances in the detection of methicillin resistant Staphylococcus aureus (MRSA)
Hulme, J. (2017) · BioChip Journal · doi:10.1007/s13206-016-1201-9 · Cited by 45
Tălăpan, D., Sandu, A.-M., & Rafilă, A. (2023) · Antibiotics · doi:10.3390/antibiotics12060974 · Cited by 47
Elbait, G. D., Daou, M., Abuoudah, M., ElMekawy, A., Hasan, S. W., Everett, D., AlSafar, H. S., Henschel, A., & Yousef, A. F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298325 · Cited by 45
Sobral, R. G., & Tomasz, A. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0068-2019 · Cited by 45
Self-citationHan, D., Yan, Y., Wang, J., Zhao, M., Duan, X., Kong, L., Wu, H., Cheng, W., Min, X., & Ding, S. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.03.050 · Cited by 45
Naha, A., Miryala, S. K., Debroy, R., Ramaiah, S., & Anbarasu, A. (2020) · Gene · doi:10.1016/j.gene.2020.144704 · Cited by 45
Pokhrel, R., Bhattarai, N., Baral, P., Gerstman, B. S., Park, J. H., Handfield, M., & Chapagain, P. P. (2019) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp01558b · Cited by 44
Targeting Bacterial Topoisomerase I to Meet the Challenge of Finding New Antibiotics
Tse‐Dinh, Y. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.14.157 · Cited by 44
The war against bacteria, from the past to present and beyond
Bottalico, L., Charitos, I. A., Potenza, M. A., Montagnani, M., & Santacroce, L. (2021) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2022.2013809 · Cited by 48
Natural product derived promising anti-MRSA drug leads: A review
Gatadi, S., Gour, J., & Nanduri, S. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.07.023 · Cited by 46
To give or not to give antibiotics is not the only question
Magalhães, C., Lima, M., Trieu‐Cuot, P., & Ferreira, P. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30602-2 · Cited by 45
WalK(S221P), a naturally occurring mutation, confers vancomycin resistance in VISA strain XN108
Peng, H., Hu, Q., Shang, W., Yuan, J., Zhang, X., Liu, H., Zheng, Y., Hu, Z., Yang, Y., Tan, L., et al. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw518 · Cited by 42
Baral, B., & Mozafari, M. R. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00005 · Cited by 42
Using genomics to understand meticillin- and vancomycin-resistant Staphylococcus aureus infections
Giulieri, S. G., Tong, S. Y. C., & Williamson, D. A. (2020) · Microbial Genomics · doi:10.1099/mgen.0.000324 · Cited by 41
Liu, G., Pang, B., Li, N., Han, J., Li, J., Wu, W., Ai, C., Jiang, C., & Shi, J. (2020) · Food & Function · doi:10.1039/d0fo00969e · Cited by 39
Hays, M. R., Kildow, B. J., Hartman, C. W., Lyden, E. R., Springer, B. D., Fehring, T. K., & Garvin, K. L. (2023) · The Journal of Arthroplasty · doi:10.1016/j.arth.2023.02.025 · Cited by 39
Wu, M., Tong, X., Liu, S., Wang, D., Wang, L., & Fan, H. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223599 · Cited by 42
Staphylococci: Evolving Genomes
Lindsay, J. A. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0071-2019 · Cited by 39
Shu, X., Shi, Y., Huang, Y., Yu, D., & Sun, B. (2023) · Nature Communications · doi:10.1038/s41467-023-37949-0 · Cited by 38
Diabetes potentiates the emergence and expansion of antibiotic resistance
Shook, J. C., Genito, C. J., Darwitz, B. P., Tyson, K. J., Velez, A. Z., Bridwell, S., Parsons, J. B., Rowe, S. E., Marshall, C. W., Conlon, B. P., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads1591 · Cited by 38
Suchý, T., Šupová, M., Klapková, E., Adámková, V., Závora, J., Žaloudková, M., Rýglová, Š., Ballay, R., Denk, F., Pokorný, M., et al. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.01.032 · Cited by 38
Altered Gut Microbiota Composition in Subjects Infected With Clonorchis sinensis
Xu, M., Jiang, Z.-H., Huang, W. C., Yin, J., Ou, S., Jiang, Y., Meng, L., Cao, S., Yu, A., Cao, J., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02292 · Cited by 37
Efficacy of experimental phage therapies in livestock
Dec, M., Wernicki, A., & Urban‐Chmiel, R. (2020) · Animal Health Research Reviews · doi:10.1017/s1466252319000161 · Cited by 38
Yahya, G., Ebada, A., Khalaf, E. M., Mansour, B., Nouh, N. A. T., Mosbah, R., Saber, S., Moustafa, M., Negm, S., El‐Sokkary, M. M. A., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9061131 · Cited by 38
Selim, S., Faried, O. A., Almuhayawi, M. S., Saleh, F. M., Sharaf, M., Nahhas, N. E., & Warrad, M. (2022) · Antibiotics · doi:10.3390/antibiotics11030408 · Cited by 40
Bakthavatchalam, Y. D., Babu, P., Munusamy, E., Dwarakanathan, H. T., Rupali, P., Zervos, M., Victor, P. J., & Veeraraghavan, B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0227009 · Cited by 37
Zhang, L., Ji, X., Su, Y., Zhai, X., Xu, H., Song, B., Jiang, A., Guo, D., & He, Y. (2020) · Nano Research · doi:10.1007/s12274-020-3039-7 · Cited by 37
Peddinti, B. S. T., Morales-Gagnon, N., Pourdeyhimi, B., Scholle, F., Spontak, R. J., & Ghiladi, R. A. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c16953 · Cited by 37
Clostridioides difficile Infection: Diagnosis and Treatment Challenges
Markantonis, J., Fallon, J. T., Madan, R., & Alam, M. Z. (2024) · Pathogens · doi:10.3390/pathogens13020118 · Cited by 38
Pereira, F., Madureira, A., Sancha, S. A. R., Mulhovo, S., Luo, X., Duarte, A., & Ferreira, M. U. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.12.009 · Cited by 36
Jadhav, M., Kalhapure, R. S., Rambharose, S., Mocktar, C., Singh, S. D., Kodama, T., & Govender, T. (2018) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.12.007 · Cited by 36
Chen, T., Chen, Q., Fu, H., Wang, D., Gao, Y., Zhang, M., & Liu, H. S. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112109 · Cited by 36
Yong, A.-L., Ooh, K.-F., Ong, H.-C., Chai, T., & Wong, F. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.11.103 · Cited by 36
Hildebrandt, P., Surmann, K., Salazar, M. G., Normann, N., Völker, U., & Schmidt, F. (2016) · Cytometry Part A · doi:10.1002/cyto.a.22981 · Cited by 34
Innovative approaches to treatStaphylococcus aureusbiofilm-related infections
Richter, K., den Driessche, F. V., & Coenye, T. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160056 · Cited by 41
Detection of critical antibiotic resistance genes through routine microbiome surveillance
Burcham, Z. M., Schmidt, C. J., Pechal, J. L., Brooks, C. P., Rosch, J. W., Benbow, M. E., & Jordan, H. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213280 · Cited by 35
Pajares‐Chamorro, N., Shook, J. C., Hammer, N. D., & Chatzistavrou, X. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.07.012 · Cited by 35
Aminovinyl Cysteine Containing Peptides: A Unique Motif That Imparts Key Biological Activity
Grant-Mackie, E. S., Williams, E. T., Harris, P. W. R., & Brimble, M. A. (2021) · JACS Au · doi:10.1021/jacsau.1c00308 · Cited by 35
Bîrluțiu, V., & Bîrluţiu, R. M. (2025) · Microorganisms · doi:10.3390/microorganisms13092194 · Cited by 43
Donkor, E. S., & Kotey, F. C. N. (2020) · Infectious Diseases Research and Treatment · doi:10.1177/1178633720976581 · Cited by 35
A Review on Antistaphylococcal Secondary Metabolites from Basidiomycetes
Vallavan, V., Krishnasamy, G., Zin, N. M., & Latif, M. A. (2020) · Molecules · doi:10.3390/molecules25245848 · Cited by 35
Cuny, C., Layer, F., Werner, G., Harmsen, D., Daniels-Haardt, I., Jurke, A., Mellmann, A., Witte, W., & Köck, R. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.02.013 · Cited by 34
Gu, G. Y., Chen, M., Pan, J. C., & Xiong, X. L. (2023) · Journal of Hospital Infection · doi:10.1016/j.jhin.2023.06.020 · Cited by 33
Ghosh, S., Basu, S., Anbarasu, A., & Ramaiah, S. (2025) · Phytotherapy Research · doi:10.1002/ptr.8365 · Cited by 33
Antimicrobial use and resistance
Reza, N., Dubey, V., Sharland, M., & Hope, W. W. (2025) · BMJ · doi:10.1136/bmj-2024-082681 · Cited by 40
Hassan, M. M., Ranzoni, A., Phetsang, W., Blaskovich, M. A. T., & Cooper, M. A. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00494 · Cited by 32
Odunitan, T. T., Oyaronbi, A. O., Adebayo, F. A., Adekoyeni, P. A., Apanisile, B. T., Oladunni, T. D., & Saibu, O. A. (2023) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2023.100034 · Cited by 32
Côté, H., Pichette, A., Simard, F., Ouellette, M.-E., Ripoll, L., Mihoub, M., Grimard, D., & Legault, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02341 · Cited by 31
Regmi, S., Choi, Y., Choi, Y. S., Kim, M. R., & Yoo, J. C. (2016) · Folia Microbiologica · doi:10.1007/s12223-016-0479-2 · Cited by 30
Liu, Y., Jia, Y., Yang, K., Li, R., Xiao, X., & Wang, Z. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00164 · Cited by 29
Development of coinage metal nanoclusters as antimicrobials to combat bacterial infections
Li, D., Kumari, B., Makabenta, J. M., Tao, B., Qian, K., Mei, X., & Rotello, V. M. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00549e · Cited by 30
Liu, X., Ren, Y., Fan, D., Huang, S., Ma, Y., Ding, J., Luo, Z., Chen, F., & Zeng, W. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202304974 · Cited by 30
METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA);
Hussain, M. S., Naqvi, A., & Sharaz, M. (2019) · The Professional Medical Journal · doi:10.29309/tpmj/2019.26.01.2510 · Cited by 29
Wang, Z., Liu, X., Peng, Y., Su, M., Zhu, S., Pan, J. M., Shen, B., Duan, Y., & Huang, Y. P. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00194 · Cited by 29
da Silva, K. B., Pinheiro, C. T. S., Soares, C. R. M., Souza, M. A., Rocha, T. J. M., Fonseca, S. A., Pavão, J. M. D. S. J., da Costa, J. G., Pires, L. L. S., & dos Santos, A. F. (2020) · Brazilian Journal of Biology · doi:10.1590/1519-6984.220259 · Cited by 29
Penna, B., Silva, M. B., Soares, A. E. R., de Vasconcelos, A. T. R., Ramundo, M. S., Ferreira, F. A., Silva-Carvalho, M. C., de Sousa, V. S., Rabello, R. F., Bandeira, P. T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83993-5 · Cited by 29
Wang, W. B., & Clapper, J. C. (2022) · Nanomaterials · doi:10.3390/nano12132139 · Cited by 29
Belete, M. A., Gedefie, A., Alemayehu, E., Debash, H., Mohammed, O., Gebretsadik, D., Ebrahim, H., & Tilahun, M. (2023) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-023-01291-3 · Cited by 32
Antimicrobial peptides and proteins against drug-resistant pathogens
Wang, Y., Song, M., & Chang, W. (2024) · The Cell Surface · doi:10.1016/j.tcsw.2024.100135 · Cited by 34
Tharmalingam, N., Rajmuthiah, R., Kim, W., Fuchs, B. B., Jeyamani, E., Kelso, M. J., & Mylonakis, E. E. (2018) · Microbial Drug Resistance · doi:10.1089/mdr.2017.0250 · Cited by 28
Sosa-Moreno, A., Comstock, S. S., Sugino, K. Y., Ma, T. F., Paneth, N., Davis, Y., Olivero, R. M., Schein, R., Maurer, J., & Zhang, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234751 · Cited by 29
Awad, M., Yosri, M., Abdel‐Aziz, M. M., Younis, A. M., & Sidkey, N. M. (2021) · Biological Trace Element Research · doi:10.1007/s12011-020-02561-6 · Cited by 28
Garcia, M. A. R., Theodoro, R. D. S., Sardi, J. D. C. O., dos Santos, M. B., Ayusso, G. M., Pavan, F. R., Costa, A. R., Cruz, L. M. S., Rosalen, P. L., & Regasini, L. O. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105279 · Cited by 27
Pet animals as reservoirs for spreading methicillin-resistant Staphylococcus aureus to human health
Khairullah, A. R., Sudjarwo, S. A., Effendi, M. H., Ramandinianto, S. C., Gelolodo, M. A., Widodo, A., Riwu, K. H. P., & Kurniawati, D. A. (2023) · Journal of Advanced Veterinary and Animal Research · doi:10.5455/javar.2023.j641 · Cited by 28
Ye, J., Hou, F., Chen, G., Zhong, T., Xue, J., Yu, F., Lai, Y., Yang, Y., Liu, D., Tian, Y., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1023036 · Cited by 27
Kebriaei, R., Rice, S., Stamper, K. C., & Rybak, M. J. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01743-18 · Cited by 27
Phenotypic Plasticity of Staphylococcus aureus in Liquid Medium Containing Vancomycin
Rong, M., Zheng, X., Ye, M., Bai, J., Xie, X., Jin, Y., & He, X. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00809 · Cited by 27
Volynets, G. P., Barthels, F., Hammerschmidt, S. J., Moshynets, O. V., Lukashov, S. S., Starosyla, S. A., Vyshniakova, H. V., Iungin, O. S., Bdzhola, V. G., Prykhod’ko, A. O., et al. (2022) · The Journal of Antibiotics · doi:10.1038/s41429-022-00524-8 · Cited by 27
Zhang, P., Sun, Y., Yang, H., Liu, D., Zhang, F., Zhang, Y., Zhong, W., Zuo, B., & Zhou, Z. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1163933 · Cited by 27
Gatadi, S., Gour, J., Shukla, M., Kaul, G., Das, S., Dasgupta, A., Madhavi, Y. V., Chopra, S., & Nanduri, S. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.11.007 · Cited by 26
Gatadi, S., Gour, J., Shukla, M., Kaul, G., Dasgupta, A., Madhavi, Y. V., Chopra, S., & Nanduri, S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.04.067 · Cited by 26
Huang, J., Wu, S., Wu, M., Zeng, Q., Wang, X., & Wang, H. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102480 · Cited by 26
On-Demand Multifunctional Electrostatic Complexation for Synergistic Eradication of MRSA Biofilms
Jiang, X., Li, W., Chen, X., Wang, C., Guo, R., & Hong, W. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c00658 · Cited by 27
Qiu, Y., Wu, Y., Lu, B., Zhu, G., Gong, T., Wang, R., Peng, Q., & Li, Y. (2020) · Biofouling · doi:10.1080/08927014.2020.1740687 · Cited by 27
Gentamicin-loaded silk/nanosilver composite scaffolds for MRSA-induced chronic osteomyelitis
Zhang, P., Qin, J., Zhang, B., Zheng, Y., Yang, L., Shen, Y., Zuo, B., & Zhang, F. (2019) · Royal Society Open Science · doi:10.1098/rsos.182102 · Cited by 25
Gizaw, F., Kekeba, T., Teshome, F., Kebede, M., Abreham, T., Hayishe, H., Waktole, H., Tufa, T. B., Edao, B. M., Ayana, D., et al. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03606 · Cited by 25
Hamad, M., Al-Marzooq, F. I., Srinivasulu, V., Omar, H. A., Sulaiman, A., Zaher, D. M., Orive, G., & Al‐Tel, T. H. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.823394 · Cited by 25
Kejela, T., & Dekosa, F. (2022) · Tropical Medicine & International Health · doi:10.1111/tmi.13789 · Cited by 25
Yao, Q., Wang, J., Cui, T., Yang, Z., Su, M., Zhao, P., Yan, H., Zhan, Y., & Yang, H. (2016) · Molecules · doi:10.3390/molecules21010062 · Cited by 25
Yang, X., Luo, M. J., Yeung, A. C. M., Lewis, P. J., Chan, P. K. S., Ip, M., & Ma, C. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00349 · Cited by 25
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Metadata
- Authors
- Gardete, S., & Tomasz, A.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Tomasz, Alexander
- Venue
- Journal of Clinical Investigation
- Published
- 2014-07-01
- Volume
- 124
- Issue
- 7
- Pages
- 2836-2840
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4071404
- OpenAlex
- W1983784984
- Cited by
- 565
- References
- 66
- Citations by year
- 2026: 26 · 2025: 53 · 2024: 71 · 2023: 48 · 2022: 53 · 2021: 57 · 2020: 49 · 2019: 66 · 2018: 40 · 2017: 43 · 2016: 29 · 2015: 25 · 2014: 4
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (2 R01 AI457838-14)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- vancomycin resistance, Staphylococcus aureus, vancomycin-intermediate Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Tn1546 transposon, vancomycin-resistant Enterococcus faecalis, cell wall biosynthesis, glycopeptides, antibiotic resistance mechanisms, cell wall metabolism
- MeSH terms
- Cell Wall, DNA Transposable Elements, DNA, Bacterial, Genes, Bacterial, Humans, Microbial Sensitivity Tests, Models, Biological, Mutation, Staphylococcal Infections, Staphylococcus aureus, Virulence, Vancomycin Resistance, Methicillin-Resistant Staphylococcus aureus
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