The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice
Open accessAbstract
Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet organelles, α-granules, release proteins that participate in thrombus formation and hemostasis. Proteins stored in α-granules are also thought to play a role in inflammation and wound healing, but their functional significance in vivo is unknown. Mutations in NBEAL2 have been linked to gray platelet syndrome (GPS), a rare bleeding disorder characterized by macrothrombocytopenia, with platelets lacking α-granules. Here we show that Nbeal2-knockout mice display the characteristics of human GPS, with defective α-granule biogenesis in MKs and their absence from platelets. Nbeal2 deficiency did not affect MK differentiation and proplatelet formation in vitro or platelet life span in vivo. Nbeal2-deficient platelets displayed impaired adhesion, aggregation, and coagulant activity ex vivo that translated into defective arterial thrombus formation and protection from thrombo-inflammatory brain infarction following focal cerebral ischemia. In a model of excisional skin wound repair, Nbeal2-deficient mice exhibited impaired development of functional granulation tissue due to severely reduced differentiation of myofibroblasts in the absence of α-granule secretion. This study demonstrates that platelet α-granule constituents are critically required not only for hemostasis but also thrombosis, acute thrombo-inflammatory disease states, and tissue reconstitution after injury.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The relevance of platelets and their products for successful tissue reconstitution is reflected in the clinical use of platelet-rich plasma to promote healing (22) and impaired healing in preclinical models recapitulating platelet disorders (23).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [23]
In the citing paper
“Inflammatory cell recruitment and activation are a consequence of many signals that occur at the wound site. Some of the earliest signals include factors released by degranulating platelets (23) and by damage- and pathogen-associated molecular patterns (DAMPs and PAMPs, respectively) where cells are damaged and microbes gain access (107).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Regulation of Wound Healing by Growth Factors and Cytokines
WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
Mechanisms of Thrombus Formation
Furie, B., & Furie, B. C. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801082 · Cited by 1,926
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1×
“Detailed characterization of the early inflammatory infiltrate will show whether their numbers differ at earlier time points in the healing process; however, large differences might have resulted in vascular abnormalities (58), which we did not detect.”
Self-citationPlatelet α-granules: Basic biology and clinical correlates
Blair, P., & Flaumenhaft, R. (2009) · Blood Reviews · doi:10.1016/j.blre.2009.04.001 · Cited by 1,157
Calcium-dependent phospholipid scrambling by TMEM16F
Suzuki, J., Umeda, M., Sims, P. J., & Nagata, S. (2010) · Nature · doi:10.1038/nature09583 · Cited by 982
Italiano, J. E., Richardson, J. L., Patel-Hett, S. R., Battinelli, E. M., Zaslavsky, A., Short, S. M., Ryeom, S. W., Folkman, J., & Klement, G. L. (2007) · Blood · doi:10.1182/blood-2007-09-113837 · Cited by 863
Savage, B., Almus-Jacobs, F., & Ruggeri, Z. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81607-4 · Cited by 816
Platelets, inflammation and tissue regeneration
Nurden, A. T. (2011) · Thrombosis and Haemostasis · doi:10.1160/ths10-11-0720 · Cited by 798
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Morowski, Blood.
- Nurden, 2008, Front Biosci., 13, 3532
Cited by
Sorted by citations
Items 101–200 of 203
Feng, Z., Ren, X., Duren, Z., & Wang, Y. (2022) · Phenomics · doi:10.1007/s43657-022-00066-x · Cited by 18
Stoll, G., Schuhmann, M. K., Nieswandt, B., Kollikowski, A. M., & Pham, M. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221105764 · Cited by 17
Self-citationImmunothrombosis versus thrombo-inflammation: platelets in cerebrovascular complications
Li, L., & Stegner, D. (2024) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2024.102344 · Cited by 17
Self-citationRole of Kv1.3 Channels in Platelet Functions and Thrombus Formation
Fan, C., Yang, X., Wang, W. W., Wang, J., Li, W., Guo, M., Huang, S., Wang, Z., & Liu, K. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314278 · Cited by 16
Platelet heterogeneity in disease: the many and the diverse?
Kaiser, R. W. J., Anjum, A., & Nicolai, L. (2025) · Blood · doi:10.1182/blood.2025028957 · Cited by 17
Schuhmann, M. K., Kraft, P., Bieber, M., Haarmann, A., Homola, G. A., Pham, M., Nieswandt, B., & Stoll, G. (2018) · Translational Stroke Research · doi:10.1007/s12975-017-0606-7 · Cited by 15
Self-citationGotru, S. K., Mammadova‐Bach, E., Sogkas, G., Schuhmann, M. K., Schmitt, K., Kraft, P., Herterich, S., Mamtimin, M., Pinarci, A., Beck, S., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318115 · Cited by 14
Self-citationUpdate on the inherited platelet disorders
Lambert, M. P. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000171 · Cited by 14
Platelet-inspired medicine for tumor therapy
Yang, J., Wang, S., Liu, P., Dai, L., Chen, B., Luan, J., & Zhou, J. (2017) · Oncotarget · doi:10.18632/oncotarget.22853 · Cited by 14
Genetic platelet depletion is superior in platelet transfusion compared to current models
Salzmann, M., Schrottmaier, W. C., Kral-Pointner, J. B., Mußbacher, M., Volz, J., Hoesel, B., Moser, B., Bleichert, S., Morava, S., Nieswandt, B., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.222448 · Cited by 14
Self-citationZebrafish for thrombocytopoiesis- and hemostasis-related researches and disorders
Meng, P., Wu, L., Lin, Q., & Zhang, Y. (2020) · Blood Science · doi:10.1097/bs9.0000000000000043 · Cited by 13
Impact of Hemostasis on the Lymphatic System in Development and Disease
Tsukiji, N., & Suzuki‐Inoue, K. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318824 · Cited by 13
Spontaneous 8bp Deletion in Nbeal2 Recapitulates the Gray Platelet Syndrome in Mice
Tomberg, K., Khoriaty, R. N., Westrick, R. J., Fairfield, H. E., Reinholdt, L. G., Brodsky, G. L., Davizon‐Castillo, P., Ginsburg, D., & Paola, J. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150852 · Cited by 13
Padilla, S., Nurden, A. T., do Prado, R. C. P., Nurden, P., & Anitua, E. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121205 · Cited by 15
Self-citationThe contribution of mouse models to the understanding of constitutional thrombocytopenia
Léon, C., Dupuis, A., Gachet, C., & Lanza, F. (2016) · Haematologica · doi:10.3324/haematol.2015.139394 · Cited by 13
Procoagulant platelets: linking coagulation and thromboinflammation in cardiovascular disease
Kaiser, R. W. J., & Nicolai, L. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01250-6 · Cited by 14
Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria
Darling, T. K., Schenk, M. P., Zhou, C., Maloba, F. M., Mimche, P. N., Gibbins, J. M., Jobe, S. M., & Lamb, T. J. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000773 · Cited by 12
Gray Platelet Syndrome Presenting With Pancytopenia, Splenomegaly, and Bone Marrow Fibrosis
Tariq, H., Botero, J. P., Higgins, R. A., & Medina, E. A. (2020) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqaa229 · Cited by 11
A role of platelet C-type lectin-like receptor-2 and its ligand podoplanin in vascular biology
Suzuki‐Inoue, K., & Tsukiji, N. (2024) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000805 · Cited by 11
Beauchemin, H., Shooshtharizadeh, P., Pinder, J. B., Dellaire, G., & Möröy, T. (2019) · Haematologica · doi:10.3324/haematol.2019.222596 · Cited by 11
Intravital Imaging of Thrombosis Models in Mice
Kiouptsi, K., Casari, M., Mandel, J., Gao, Z., & Deppermann, C. (2023) · Hämostaseologie · doi:10.1055/a-2118-2932 · Cited by 10
Self-citationStritt, S., Thielmann, I., Dütting, S., Stegner, D., & Nieswandt, B. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12623 · Cited by 10
Self-citationPlatelet granules in vascular integrity
Meyer, S. F. D. (2017) · Blood · doi:10.1182/blood-2017-02-763540 · Cited by 10
Cao, L., Su, J. J., Li, J., Yu, Z., Bai, X., Wang, Z., Xia, L., & Ruan, C. (2017) · Platelets · doi:10.1080/09537104.2017.1306041 · Cited by 10
Janus‐Bell, E., Receveur, N., Mercier, L., Mouriaux, C., Magnenat, S., Reiser, J., Lanza, F., Hechler, B., Ho‐Tin‐Noé, B., & Mangin, P. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321104 · Cited by 9
Evolutionary Insight into Immunothrombosis as a Healing Mechanism
Anitua, E., do Prado, R. C. P., & Padilla, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158346 · Cited by 10
Pluthero, F. G., & Kahr, W. H. A. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15177 · Cited by 9
Inherited Disorders of Platelet Function
Cattaneo, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813456-6.00048-5 · Cited by 9
Unlocking the Molecular Secrete(s) of α-Granule Biogenesis
Noetzli, L. J., & Italiano, J. E. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311614 · Cited by 9
Platelet-Derived PDGF-A Disrupts Blood-Brain Barrier Integrity in Ischemic Stroke—Brief Report
Göb, V., Zimmermann, L., Hemmen, K., Haarmann, A., Heinze, K. G., Schuhmann, M. K., & Stegner, D. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.321191 · Cited by 11
Self-citationTariket, S., Guerrero, J. A., Garraud, O., Ghevaert, C., & Cognasse, F. (2018) · Transfusion · doi:10.1111/trf.14970 · Cited by 8
Genetic basis of congenital platelet disorders
Hinckley, J. D., & Paola, J. A. D. (2014) · Hematology · doi:10.1182/asheducation-2014.1.337 · Cited by 8
Polylysine and its composites as a potent biomaterial for biomedical applications: a review
Chauhan, N. P. S., Jhala, K., Singh, G. P., Rathore, R., Pannnersevam, P., Simorgh, S., & Jadoun, S. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.128331 · Cited by 7
Platelets and ductus arteriosus closure in neonates
Sallmon, H., & Delaney, C. A. (2023) · Seminars in Perinatology · doi:10.1016/j.semperi.2023.151719 · Cited by 7
Silverstein, R. L. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303687 · Cited by 7
Immune dysregulation, autoimmunity, and granule defects in gray platelet syndrome
Collins, J., Mayer, L., & Guerrero, J. A. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.03.032 · Cited by 6
Tang, Y., Wu, H., Huo, C., Zou, S., Hu, Y., & Yang, H. (2022) · Viruses · doi:10.3390/v14020292 · Cited by 6
Kat, M., van Moort, I., Bürgisser, P. E., Kuijpers, T. W., Hofman, M., Favier, M., Favier, R., Margadant, C., Voorberg, J., & Bierings, R. (2023) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2023.100086 · Cited by 6
Tsai, J.-C., Lin, Y.-W., Huang, C., Lin, F., & Tsai, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/484510 · Cited by 6
Extracellular chloride is required for efficient platelet aggregation
Taylor, K. A., Wilson, D. G. S., Harper, M. T., & Pugh, N. (2017) · Platelets · doi:10.1080/09537104.2017.1332367 · Cited by 6
Variation in platelet‐rich plasma compositions used for wound healing indications
van der Bijl, I., de Korte, D., & Middelkoop, E. (2020) · Wound Repair and Regeneration · doi:10.1111/wrr.12886 · Cited by 6
GRIPAP1 is an endosomal tethering factor mediating platelet α-granule biogenesis
Ambrosio, A. L., Febvre, H. P., Schusler, G. H., & Pietro, S. M. D. (2026) · The Journal of Cell Biology · doi:10.1083/jcb.202507149 · Cited by 5
Molecular and Cellular Biology of Platelet Formation
Italiano, J. E., & Schulze, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-39562-3 · Cited by 7
Introduction to Wound Healing and Tissue Repair
Eming, S. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-98477-3_5 · Cited by 6
Self-citationThe Role of Platelets Beyond Hemostasis
Reusswig, F., & Deppermann, C. (2026) · Hämostaseologie · doi:10.1055/a-2755-7600 · Cited by 4
Self-citationDense but not alpha granules of platelets are required for insulin secretion from pancreatic β cells
Kolczyńska, K., Karwen, T., Loeffler, M., Hawro, I., Kassouf, T., Stegner, D., & Sumara, G. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150753 · Cited by 4
Self-citationFlaumenhaft, R. C., & Koseoglu, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-39562-3_6 · Cited by 4
Wegner, P., Drube, J., Ziegler, L., Strotmann, B., Marquardt, R., Küchler, C., Groth, M., Nieswandt, B., Andreas, N., & Drube, S. (2024) · Immunology · doi:10.1111/imm.13756 · Cited by 4
Self-citationPosey, J. N., Jordan, M., Lewis, C., Sul, C., Dobrinskikh, E., Swindle, D. C., Denorme, F., Irwin, D. C., Paola, J. D., Stenmark, K. R., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013880 · Cited by 4
Congenital and Acquired Disorders of Platelet Function and Number
Jobe, S. M., & Paola, J. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-46202-0.00009-1 · Cited by 3
Platelets in Acute Ischemic Stroke
Stoll, G., Kleinschnitz, C., & Nieswandt, B. (2017) · Springer eBooks · doi:10.1007/978-3-319-47462-5_68 · Cited by 3
Self-citationA Case of Chronic Thrombocytopenia in a 17-Year-Old Female
Riley, R. S., Khan, A., Pai, S., Warmke, L. M., Winkler, M. R., & Gunning, W. T. (2019) · Laboratory Medicine · doi:10.1093/labmed/lmz013 · Cited by 3
Conventional and Secretory Lysosomes
Shrestha, R., Kaplan, J., & Ward, D. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.20019-9 · Cited by 3
Platelet endocytosis and α-granule cargo packaging are essential for normal skin wound healingPreprint
Coenen, D. M., Alfar, H. R., & Whiteheart, S. W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.01.636051 · Cited by 3
Flaumenhaft, R. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-47462-5_26 · Cited by 2
Shahraki, H., Dorgalaleh, A., & Bain, B. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-76723-9_16 · Cited by 2
Swieringa, F. (2016) · doi:10.26481/dis.20160331fs · Cited by 2
Flaumenhaft, R. C. (2025) · Springer eBooks · doi:10.1007/978-3-031-96344-5_5 · Cited by 1
Platelets in Acute Ischemic Stroke
Nieswandt, B., Schuhmann, M. K., Stegner, D., & Stoll, G. (2025) · Springer eBooks · doi:10.1007/978-3-031-96352-0_11 · Cited by 1
Self-citationClostridium butyricum ameliorates atherosclerotic inflammation through regulation of gut microbiota
Wang, J., Ma, J., Li, Y., Liu, Y., Shen, W., Liu, J., Wang, H., Zhang, Y., & Zhang, X. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116315 · Cited by 1
ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ
Akar, S., & Çetin, E. Ö. (2020) · SDÜ Tıp Fakültesi Dergisi · doi:10.17343/sdutfd.641016 · Cited by 1
Gray Platelet Syndrome: Diagnosis and Management
Kianinodeh, F., Hosseini, M. S., & Bain, B. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-43156-2_17 · Cited by 1
Whiteheart, S. W. (2013) · Blood · doi:10.1182/blood-2013-07-516880
Thrombopénie et plaquettes grises
Lapillonne, H. (2015) · Revue d Oncologie Hématologie Pédiatrique · doi:10.1016/j.oncohp.2014.12.003
Zespół szarych płytek Gray platelet syndrome
Szumera‐Ciećkiewicz, A., & Prochorec‐Sobieszek, M. (2014)
Identification of Thrombosis Modifier Genes Using ENU Mutagenesis in the Mouse.
Tomberg, K. (2016) · Deep Blue (University of Michigan)
Shrestha, R. (2016) · J. Willard Marriott Library · doi:10.26053/0h-n132-6w00
Guo, L. (2016) · TSpace (University of Toronto)
Mouse Models for Platelet Production and Function
Bender, M., & Nieswandt, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-39562-3_11
Self-citationCherpokova, D., & Nieswandt, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-39562-3_13
Self-citationRegulation of Megakaryocyte and Platelet Survival
Au, A. E., Lebois, M., Pleines, I., & Josefsson, E. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-39562-3_9
The Role of CLEC-2 in and Beyond the Vasculature
Rayes, J., Hardy, A. T., Lombard, S. E., Montague, S. J., Watson, S. P., & Lowe, K. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-47462-5_10
Frydman, G. H., Pate, K. A. M., & Vitsky, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64247-2
Pseudo gray platelet syndrome with platelet clumpingの1例とレビュー
寿美代, 宮., 真司, 大., 雅美, 見., 恵美子, 佐., 小泉, 忠., & 乾, 古. (2018) · 医学検査 · doi:10.14932/jamt.17-53
Characterization of an NBEAL2-interacting partner
To, K. (2018) · TSpace (University of Toronto)
Lesyk, G. M. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-pk4m-h082
The roles of podoplanin and clec-2 in the development and maintenance of the cerebral vasculature
Lowe, K. L. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)
Clemetson, K. J. (2019) · doi:10.1002/9781119252863.ch19
Li, Z., Gnatenko, D. V., & Bahou, W. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-47462-5_16
Fukuda, M., & Ohbayashi, N. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735464281.793574979
(2013) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.25.110
Prognostic Significance of NBEAL2 in Liver hepatocellular carcinomaPreprint
Wen, Y., Su, H., Wang, W., Ren, F., Jiang, H., Wang, J., Xiang, J., & Chen, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-471663/v1
Conventional and Secretory Lysosomes
Shrestha, R., Kaplan, J., & Ward, D. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.20019-9
The effect of T-lysine cream on the wound healing process
Haydar, A. A. (2023) · Zanco Journal of Medical Sciences · doi:10.15218/zjms.2023.025
Clemetson, K. J. (2024) · doi:10.1002/9781394180486.ch18
Ebrahimpour, A., Wang, M., Li, L., Jegga, A. G., Bonnen, M., Eissa, N. T., Raghu, G., Jyothula, S., Kheradmand, F., Hanania, N. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14623160
Ebrahimpour, A., Wang, M., Li, L., Jegga, A. G., Bonnen, M., Eissa, N. T., Raghu, G., Jyothula, S., Kheradmand, F., Hanania, N. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14623163
Ebrahimpour, A., Wang, M., Li, L., Jegga, A. G., Bonnen, M., Eissa, N. T., Raghu, G., Jyothula, S., Kheradmand, F., Hanania, N. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14623166
Frydman, G. H., Pate, K. A. M., & Vitsky, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00135-2
Clostridium Butyricum Ameliorates Atherosclerotic Inflammation Through Regulation of Gut MicrobiotaPreprint
Wang, J., Ma, J., Li, Y., Liu, Y., Shen, W., Liu, J., Wang, H., Zhang, Y., & Zhang, X. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5392489
Pradeep, A., Falade, A. S., Botero, J. P., Chen, D., Pruthi, R. K., & Matin, A. (2025) · Annals of Hematology · doi:10.1007/s00277-025-06587-5
Clostridium butyricum ameliorates atherosclerotic inflammation through regulation of gut microbiotaPreprint
Wang, J., Ma, J., Li, Y., Liu, Y., Shen, W., Liu, J., Wang, H., Zhang, Y., & Zhang, X. (2025) · Research Square · doi:10.21203/rs.3.rs-7249459/v1
Alternative Functions of Megakaryocytes
Morrell, C. N., & Livada, A. C. (2025) · Springer eBooks · doi:10.1007/978-3-031-96340-7_7
Tan, K., Harris, S. E., Maddock, J., Tay, D., Jain, P., The HELIOS Study Team, Mok, S. Q., Herbrard, M., Schminke, U., Xue, C., et al. (2025) · medRxiv · doi:10.1101/2025.11.21.25340774
Ebrahimpour, A., Wang, M., Li, L., Jegga, A. G., Bonnen, M. D., Eissa, N. T., Raghu, G., Jyothula, S., Kheradmand, F., Hanania, N. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14623169
Schuhmann, M. K., Bieber, M., Franke, M., Kollikowski, A. M., Stegner, D., Heinze, K. G., Nieswandt, B., Pham, M., & Stoll, G. (2021) · Figshare · doi:10.6084/m9.figshare.14059234
Self-citation(2026) · American Registry of PathologyArlington, Virginia eBooks · doi:10.55418/9781933477664-10
Tan, K., Harris, S., Maddock, J., Tay, D., Jain, P. R., Science, H., Mok, S. Q., Hebrard, M., Schminke, U., Xue, C. C., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9046066/v1
An, O. I., Reusswig, F., Krenzlin, V., Deppermann, C., & van der Wal, D. E. (2026) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2026.103414
Self-citationBEACH domain-containing proteins: emerging roles in hematopoiesis and immune homeostasis
Hateley, A., & Ganuza, M. (2026) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000921
Metadata
- Authors
- Deppermann, C., Cherpokova, D., Nurden, P., Schulz, J.-N., Thielmann, I., Kraft, P., Vögtle, T., Kleinschnitz, C., Dütting, S., Krohne, G., Eming, S. A., Nurden, A. T., Eckes, B., Stoll, G., Stegner, D., & Nieswandt, B.
- Affiliations
- University of Würzburg (DE)
- University of Cologne (DE)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2013-07-01
- Volume
- 123
- Issue
- 8
- Pages
- 3331-3342
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4011026
- OpenAlex
- W1982213737
- Cited by
- 200
- References
- 66
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 13 · 2023: 9 · 2022: 6 · 2021: 16 · 2020: 15 · 2019: 18 · 2018: 18 · 2017: 16 · 2016: 22 · 2015: 19 · 2014: 22 · 2013: 5
- FWCI
- 16.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB829, SFB 688)
- Julius-Maximilians-Universität Würzburg
- Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- gray platelet syndrome, NBEAL2, alpha-granules, megakaryocytes, thromboinflammation, arterial thrombus formation, focal cerebral ischemia, cerebral infarction, platelet adhesion and aggregation, coagulant activity, hemostasis, wound healing, myofibroblast differentiation, granulation tissue, bleeding disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
