The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Tumor neoantigens: building a framework for personalized cancer immunotherapy
Open accessAbstract
It is now well established that the immune system can recognize developing cancers and that therapeutic manipulation of immunity can induce tumor regression. The capacity to manifest remarkably durable responses in some patients has been ascribed in part to T cells that can (a) kill tumor cells directly, (b) orchestrate diverse antitumor immune responses, (c) manifest long-lasting memory, and (d) display remarkable specificity for tumor-derived proteins. This specificity stems from fundamental differences between cancer cells and their normal counterparts in that the former develop protein-altering mutations and undergo epigenetic and genetic alterations, resulting in aberrant protein expression. These events can result in formation of tumor antigens. The identification of mutated and aberrantly expressed self-tumor antigens has historically been time consuming and laborious. While mutant antigens are usually expressed in a tumor-specific manner, aberrantly expressed antigens are often shared between cancers and, therefore, in the past, have been the major focus of therapeutic cancer vaccines. However, advances in next-generation sequencing and epitope prediction now permit the rapid identification of mutant tumor neoantigens. This review focuses on a discussion of mutant tumor neoantigens and their use in personalizing cancer immunotherapies.
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Cited by
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers
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Cancer immunoediting and resistance to T cell-based immunotherapy
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Cancer immunotherapy: harnessing the immune system to battle cancer
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Neoantigens: promising targets for cancer therapy
Xie, N., Shen, G., Gao, W., Huang, Z., Huang, C., & Fu, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01270-x · Cited by 1,020
Targeting neoantigens to augment antitumour immunity
Yarchoan, M., Johnson, B. A., Lutz, E. R., Laheru, D. A., & Jaffee, E. M. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.154 · Cited by 997
Metadata
- Authors
- Gubin, M. M., Artyomov, M. N., Mardis, E. R., & Schreiber, R. D.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-08-10
- Volume
- 125
- Issue
- 9
- Pages
- 3413-3421
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1607316259
- Cited by
- 613
- References
- 102
- FWCI
- 22.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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