The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes
Open accessAbstract
The nervous and immune systems interact in complex ways to maintain homeostasis and respond to stress or injury, and rapid nerve conduction can provide instantaneous input for modulating inflammation. The inflammatory reflex referred to as the cholinergic antiinflammatory pathway regulates innate and adaptive immunity, and modulation of this reflex by vagus nerve stimulation (VNS) is effective in various inflammatory disease models, such as rheumatoid arthritis and inflammatory bowel disease. Effectiveness of VNS in these models necessitates the integration of neural signals and α7 nicotinic acetylcholine receptors (α7nAChRs) on splenic macrophages. Here, we sought to determine whether electrical stimulation of the vagus nerve attenuates kidney ischemia-reperfusion injury (IRI), which promotes the release of proinflammatory molecules. Stimulation of vagal afferents or efferents in mice 24 hours before IRI markedly attenuated acute kidney injury (AKI) and decreased plasma TNF. Furthermore, this protection was abolished in animals in which splenectomy was performed 7 days before VNS and IRI. In mice lacking α7nAChR, prior VNS did not prevent IRI. Conversely, adoptive transfer of VNS-conditioned α7nAChR splenocytes conferred protection to recipient mice subjected to IRI. Together, these results demonstrate that VNS-mediated attenuation of AKI and systemic inflammation depends on α7nAChR-positive splenocytes.
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Cites
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Cited by
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
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Self-citationNeural regulation of immunity: molecular mechanisms and clinical translation
Pavlov, V. A., & Tracey, K. J. (2017) · Nature Neuroscience · doi:10.1038/nn.4477 · Cited by 532
Molecular and functional neuroscience in immunity
Pavlov, V. A., Chavan, S. S., & Tracey, K. J. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053158 · Cited by 444
Bonaz, B., Sinniger, V., & Pellissier, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01452 · Cited by 405
The vagus nerve in appetite regulation, mood, and intestinal inflammation
Browning, K. N., Verheijden, S., & Boeckxstaens, G. E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.046 · Cited by 361
Metadata
- Authors
- Inoue, T., Abe, C., Sung, S.-S. J., Moscalu, S., Jankowski, J., Huang, L., Ye, H., Rosin, D. L., Guyenet, P. G., & Okusa, M. D.
- Venue
- Journal of Clinical Investigation
- Published
- 2016-04-18
- Volume
- 126
- Issue
- 5
- Pages
- 1939-1952
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2340542419
- Cited by
- 309
- References
- 56
- FWCI
- 15.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Inoue, T., Abe, C., Sung, S.-S. J., Moscalu, S., Jankowski, J., Huang, L., Ye, H., Rosin, D. L., Guyenet, P. G., & Okusa, M. D. (2016). Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. Journal of Clinical Investigation. https://doi.org/10.1172/jci83658
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