Molecular and functional neuroscience in immunity

The third international consensus definitions for sepsis and septic shock (Sepsis-3).

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works

The inflammatory reflex

Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Towards a network theory of the immune system.

Nk, J. (1974) · PubMed · Cited by 3,388 · see citing works

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228 · see citing works

Pro-resolving lipid mediators are leads for resolution physiology

Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works

A mesoscale connectome of the mouse brain

Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612 · see citing works

Long-term cognitive impairment and functional disability among survivors of severe sepsis.

Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582 · see citing works

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579 · see citing works

The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System

Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252 · see citing works

Nonresolving Inflammation

Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

Gut feelings: the emerging biology of gut-brain communication

Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works

Disease Tolerance as a Defense Strategy

Medzhitov, R., Schneider, D. S., & Soares, M. P. (2012) · Science · doi:10.1126/science.1214935 · Cited by 1,718 · see citing works

Stroke-Associated Pneumonia: Major Advances and Obstacles

Hannawi, Y., Hannawi, B., Rao, C. P. V., Suárez, J. I., & Bershad, E. M. (2013) · Cerebrovascular Diseases · doi:10.1159/000350199 · Cited by 1,657 · see citing works

Metabolic Syndrome Pandemic

Grundy, S. M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151092 · Cited by 1,571 · see citing works

Physiology and immunology of the cholinergic antiinflammatory pathway

Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · cited 4× · see citing works

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551 · see citing works

The Central Autonomic Network: Functional Organization, Dysfunction, and Perspective

BENARROCH, E. E. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62272-1 · Cited by 1,534 · see citing works

Nociceptors: the sensors of the pain pathway

Dubin, A. E., & Patapoutian, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42843 · Cited by 1,418 · see citing works

Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell · doi:10.1016/j.cell.2005.10.041 · Cited by 1,412 · see citing works

Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury

Brines, M. L., Ghezzi, P., Keenan, S., Agnello, D., de Lanerolle, N. C., Cerami, C., Itri, L. M., & Cerami, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.19.10526 · Cited by 1,402 · see citing works

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works

Functional and chemical anatomy of the afferent vagal system

Berthoud, H.-R., & Neuhuber, W. L. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00215-0 · Cited by 1,280 · see citing works

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

Girard, T. D., Jackson, J. C., Pandharipande, P. P., Pun, B. T., Thompson, J. L., Shintani, A., Gordon, S. M., Canonico, A. E., Dittus, R. S., Bernard, G. R., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e47be1 · Cited by 1,216 · see citing works

Astrocyte barriers to neurotoxic inflammation

Sofroniew, M. V. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3898 · Cited by 1,202 · see citing works

Medical Complications After Stroke: A Multicenter Study

Langhorne, P., Stott, D. J., Robertson, L., MacDonald, J., Jones, L., McAlpine, C., Dick, F., Taylor, G. S., & Murray, G. (2000) · Stroke · doi:10.1161/01.str.31.6.1223 · Cited by 1,196 · see citing works

Immune system to brain signaling: Neuropsychopharmacological implications

Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195 · see citing works

Central modulation of pain

Ossipov, M. H., Dussor, G. O., & Porreca, F. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43766 · Cited by 1,165 · see citing works

TRP Channels and Pain

Julius, D. J. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155833 · Cited by 1,152 · see citing works

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Oetjen, L. K., Mack, M. R., Feng, J., Whelan, T. M., Niu, H., Guo, C. J., Chen, S., Trier, A. M., Xu, A. Z., Tripathi, S. V., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.006 · Cited by 1,092 · see citing works

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074 · see citing works

Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens

Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064 · see citing works

The vagus nerve and the inflammatory reflex – linking immunity and metabolism

Pavlov, V. A., & Tracey, K. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.189 · Cited by 1,040 · see citing works

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

Pinho-Ribeiro, F. A., Verri, W. A., Jr., & Chiu, I. M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.10.001 · Cited by 1,031 · see citing works

Long-term Consequences of Postoperative Cognitive Dysfunction

Steinmetz, J., Christensen, K. B., Lund, T., Lohse, N., & Rasmussen, L. S. (2009) · Anesthesiology · doi:10.1097/aln.0b013e318195b569 · Cited by 1,026 · see citing works

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

Koopman, F. A., Chavan, S. S., Miljko, S., Grazio, S., Sokolovic, S., Schuurman, P. R., Mehta, A. D., Levine, Y. A., Faltys, M., Zitnik, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605635113 · Cited by 1,024 · see citing works

Sepsis: a roadmap for future research

Cohen, J., Vincent, J., Adhikari, N. K. J., Machado, F. R., Angus, D. C., Calandra, T., Jaton, K., Giulieri, S. G., Delaloye, J., Opal, S. M., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70112-x · Cited by 996 · see citing works

Central nervous system injury-induced immune deficiency syndrome

Meisel, C., Schwab, J. M., Prass, K., Meisel, A., & Dirnagl, U. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1765 · Cited by 974 · see citing works

Neuroendocrine Regulation of Immunity

Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957 · see citing works

Systemic inflammation and microglial activation: systematic review of animal experiments

Hoogland, I. C. M., Houbolt, C., van Westerloo, D. J., van Gool, W. A., & van de Beek, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0332-6 · Cited by 957 · see citing works

Descending control of nociception: Specificity, recruitment and plasticity

Heinricher, M. M., Tavares, I., Leith, J. L., & Lumb, B. M. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.009 · Cited by 953 · see citing works

Bacteria activate sensory neurons that modulate pain and inflammation

Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949 · see citing works

Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation

Prass, K., Meisel, C., Höflich, C., Braun, J., Halle, E., Wolf, T., Ruscher, K., Victorov, I. V., Priller, J., Dirnagl, U., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021098 · Cited by 927 · see citing works

Restoring cortical control of functional movement in a human with quadriplegia

Bouton, C. E., Shaikhouni, A., Annetta, N. V., Bockbrader, M. A., Friedenberg, D. A., Nielson, D. M., Sharma, G., Sederberg, P. B., Glenn, B. C., Mysiw, W. J., et al. (2016) · Nature · doi:10.1038/nature17435 · Cited by 924 · see citing works

Mechanisms of sensory transduction in the skin

Lumpkin, E. A., & Caterina, M. J. (2007) · Nature · doi:10.1038/nature05662 · Cited by 860 · see citing works

Sepsis-associated encephalopathy

Gofton, T. E., & Young, G. B. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.183 · Cited by 821 · see citing works

The Enteric Nervous System

Goyal, R. K., & Hirano, I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604253341707 · Cited by 774 · see citing works

The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation

Pavlov, V. A., Wang, H., Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003) · Molecular Medicine · doi:10.1007/bf03402177 · Cited by 772 · see citing works

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

Rosas‐Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y., Huston, J. M., Chavan, S. S., & Tracey, K. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803237105 · Cited by 757 · see citing works

Role of interleukin‐1β in postoperative cognitive dysfunction

Cibelli, M., Fidalgo, A. R., Terrando, N., Ma, D., Monaco, C. G., Feldmann, M., Takata, M., Lever, I. J., Nanchahal, J., Fanselow, M. S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22082 · Cited by 742 · see citing works

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

Ballinger, E. C., Ananth, M. R., Talmage, D. A., & Role, L. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.006 · Cited by 735 · see citing works

Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline

Terrando, N., Monaco, C. G., Ma, D., Foxwell, B. M. J., Feldmann, M., & Maze, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014557107 · Cited by 730 · see citing works

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

Chiu, I. M., von Hehn, C. A., & Woolf, C. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3144 · Cited by 686 · see citing works

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

Huston, J. M., Ochani, M., Rosas-Ballina, M., Liao, H., Ochani, K., Pavlov, V. A., Gallowitsch-Puerta, M., Ashok, M., Czura, C. J., Foxwell, B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052362 · Cited by 683 · see citing works

ASTHMA AS AN AXON REFLEX

Barnes, P. J. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90777-4 · Cited by 670 · see citing works

Nociceptors Are Interleukin-1β Sensors

Binshtok, A. M., Wang, H., Zimmermann, K., Amaya, F., Vardeh, D., Shi, L., Brenner, G. J., Ji, R., Bean, B. P., Woolf, C. J., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3795-08.2008 · Cited by 664 · see citing works

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Chavan, S. S., Pavlov, V. A., & Tracey, K. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.008 · Cited by 661 · see citing works

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

Gabanyi, I., Muller, P. A., Feighery, L. M., Oliveira, T. Y., Costa‐Pinto, F. A., & Mucida, D. (2016) · Cell · doi:10.1016/j.cell.2015.12.023 · Cited by 658 · see citing works

Sepsis-induced immune dysfunction: can immune therapies reduce mortality?

Delano, M. J., & Ward, P. A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82224 · Cited by 652 · see citing works

Sensory neurons that detect stretch and nutrients in the digestive system

Williams, E. K., Chang, R. B., Strochlic, D. E., Umans, B. D., Lowell, B. B., & Liberles, S. D. (2016) · Cell · doi:10.1016/j.cell.2016.05.011 · Cited by 645 · see citing works

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Wallrapp, A., Riesenfeld, S. J., Burkett, P. R., Abdulnour, R.-E. E., Nyman, J., Dionne, D. A., Hofree, M., Cuoco, M. S., Rodman, C., Farouq, D., et al. (2017) · Nature · doi:10.1038/nature24029 · Cited by 641 · see citing works

Dopamine mediates vagal modulation of the immune system by electroacupuncture

Rosas, R. T., Yehia, G., Peña, G., Mishra, P., Thompson-Bonilla, M. D. R., Moreno‐Eutímio, M. A., Arriaga‐Pizano, L., Isibasi, A., & Ulloa, L. (2014) · Nature Medicine · doi:10.1038/nm.3479 · Cited by 633 · see citing works

Long-term mortality and quality of life in sepsis: A systematic review*

Winters, B. D., Eberlein, M. H., Leung, J. M., Needham, D. M., Pronovost, P. J., & Sevransky, J. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181d8cc1d · Cited by 619 · see citing works

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

Cardoso, V., Chesné, J., Ribeiro, H., García-Cassani, B., Carvalho, T., Bouchery, T., Shah, K., Barbosa-Morais, N. L., Harris, N., & Veiga-Fernandes, H. (2017) · Nature · doi:10.1038/nature23469 · Cited by 592 · see citing works

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

Serhan, C. N., Chiang, N., & Dalli, J. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.004 · Cited by 583 · see citing works

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Klose, C. S. N., Mahlakõiv, T., Moeller, J. B., Rankin, L. C., Flamar, A.-L., Kabata, H., Monticelli, L. A., Moriyama, S., Putzel, G., Rakhilin, N., et al. (2017) · Nature · doi:10.1038/nature23676 · Cited by 570 · see citing works

Systemic infection and delirium: when cytokines and acetylcholine collide

van Gool, W. A., van de Beek, D., & Eikelenboom, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61158-2 · Cited by 562 · see citing works

Vagal Afferent Innervation of the Airways in Health and Disease

Mazzone, S. B., & Undem, B. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00039.2015 · Cited by 562 · see citing works

Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence

Hshieh, T. T., Fong, T. G., Marcantonio, E. R., & Inouye, S. K. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.7.764 · Cited by 553 · see citing works

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

Scheiermann, C., Kunisaki, Y., Lucas, D., Chow, A. T., Jang, J.-E., Zhang, D., Hashimoto, D., Mérad, M., & Frenette, P. S. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.021 · Cited by 535 · see citing works

Neural regulation of immunity: molecular mechanisms and clinical translation

Pavlov, V. A., & Tracey, K. J. (2017) · Nature Neuroscience · doi:10.1038/nn.4477 · Cited by 534 · see citing works

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome

Mira, J. C., Gentile, L. F., Mathias, B. J., Efron, P. A., Brakenridge, S. C., Mohr, A. M., Moore, F. A., & Moldawer, L. L. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002074 · Cited by 526 · see citing works

Vagal immune-to-brain communication: a visceral chemosensory pathway

Goehler, L. E., Gaykema, R. P. A., Hansen, M. K., Anderson, K., Maier, S. F., & Watkins, L. R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00219-8 · Cited by 525 · see citing works

Brainstem circuits regulating gastric function

Travagli, R. A., Hermann, G. E., Browning, K. N., & Rogers, R. C. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040504.094635 · Cited by 498 · see citing works

Chronic vagus nerve stimulation in Crohn's disease: a 6‐month follow‐up pilot study

Bonaz, B., Sinniger, V., Hoffmann, D., Clarençon, D., Mathieu, N., Dantzer, C., Vercueil, L., Picq, C., Trocmé, C., Faure, P., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12792 · Cited by 492 · see citing works

Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation

Saeed, R. W., Varma, S., Peng-Nemeroff, T., Sherry, B., Balakhaneh, D., Huston, J., Tracey, K. J., Al-Abed, Y., & Metz, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040463 · Cited by 489 · see citing works

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

Yoo, B. B., & Mazmanian, S. K. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.011 · Cited by 479 · see citing works

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation

Talbot, S., Abdulnour, R.-E. E., Burkett, P. R., Lee, S., Cronin, S. J., Pascal, M., Laedermann, C., Foster, S. L., Tran, J., Lai, N. Y., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.007 · Cited by 455 · see citing works

Prevalence of rheumatoid arthritis in the United States adult population in healthcare claims databases, 2004–2014

Hunter, T. M., Boytsov, N. N., Zhang, X., Schroeder, K. M., Michaud, K. D., & de Araújo, A. B. (2017) · Rheumatology International · doi:10.1007/s00296-017-3726-1 · Cited by 451 · see citing works

The Neurobiology of Dopamine Signaling

Girault, J., & Greengard, P. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.641 · Cited by 443 · see citing works

Activation in vagal afferents and central autonomic pathways: Early responses to intestinal infection with Campylobacter jejuni

Goehler, L. E., Gaykema, R. P. A., Opitz, N., Reddaway, R., Badr, N., & Lyte, M. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.09.002 · Cited by 442 · see citing works

Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway

Pavlov, V. A., Parrish, W. R., Rosas‐Ballina, M., Ochani, M., Gallowitsch‐Puerta, M., Ochani, K., Chavan, S. S., Al‐Abed, Y., & Tracey, K. J. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.06.011 · Cited by 437 · see citing works

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

Chang, R. B., Strochlic, D. E., Williams, E. K., Umans, B. D., & Liberles, S. D. (2015) · Cell · doi:10.1016/j.cell.2015.03.022 · Cited by 434 · see citing works

Regulation of B-Cell Growth and Differentiation by Soluble Factors

Howard, M., & Paul, W. E. (1983) · Annual Review of Immunology · doi:10.1146/annurev.iy.01.040183.001515 · Cited by 431 · see citing works

Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke

Wong, C. H. Y., Jenne, C., Lee, W.-Y., Léger, C., & Kubes, P. (2011) · Science · doi:10.1126/science.1210301 · Cited by 424 · see citing works

Reflex principles of immunological homeostasis

Andersson, U., & Tracey, K. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075015 · Cited by 414 · see citing works

The Vagus Nerve: A Tonic Inhibitory Influence Associated With Inflammatory Bowel Disease in a Murine Model

Ghia, J., Blennerhassett, P. A., Kumar–Ondiveeran, H., Verdu, E. F., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.016 · Cited by 404 · see citing works

Key role of CRF in the skin stress response system

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Neural control of the spleen as an effector of immune responses to inflammation: mechanisms and treatments

Mota, C. M. D., & Madden, C. J. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00151.2022 · Cited by 65 · see citing works

Pathophysiology of Sepsis and Genesis of Septic Shock: The Critical Role of Mesenchymal Stem Cells (MSCs)

Daniel, M., Bedoui, Y., Vagner, D., Raffray, L., Ah-Pine, F., Doray, B., & Gasque, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169274 · Cited by 77 · see citing works

The role of neuroinflammation in the transition of acute to chronic pain and the opioid-induced hyperalgesia and tolerance

Echeverria-Villalobos, M., Tortorici, V., Brito, B. E., Ryskamp, D., Uribe, A. A., & Weaver, T. E. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1297931 · Cited by 64 · see citing works

Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation

Keever, K. R., Cui, K., Casteel, J. L., Singh, S., Hoover, D. B., Williams, D. L., Pavlov, V. A., & Yakubenko, V. P. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-03001-7 · Cited by 63 · see citing works

Metabolic and Immune Crosstalk in Cardiovascular Disease

Mohanta, S. K., Heron, C., Klaus‐Bergmann, A., Horstmann, H., Bråkenhielm, E., Giannarelli, C., Habenicht, A. J. R., Gerhardt, H., & Weber, C. (2025) · Circulation Research · doi:10.1161/circresaha.125.325496 · Cited by 67 · see citing works

Immunoception: the insular cortex perspective

Rolls, A. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01051-8 · Cited by 62 · see citing works

Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome

Stavrakis, S., Chakraborty, P., Farhat, K., Whyte, S., Morris, L. M., Asad, Z. U. A., Karfonta, B., Anjum, J., Matlock, H. G., Cai, X., et al. (2023) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2023.10.015 · Cited by 63 · see citing works

The systemic immune response in Parkinson’s disease: focus on the peripheral immune component

Lauritsen, J., & Romero‐Ramos, M. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.005 · Cited by 61 · see citing works

Area postrema neurons mediate interleukin-6 function in cancer cachexia

Sun, Q., van de Lisdonk, D., Ferrer, M., Gegenhuber, B., Wu, M., Park, Y., Tuveson, D., Tollkuhn, J., Janowitz, T., & Li, B. (2024) · Nature Communications · doi:10.1038/s41467-024-48971-1 · Cited by 60 · see citing works

Bioelectronic medicine: updates, challenges and paths forward

Pavlov, V. A., & Tracey, K. J. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0018-y · Cited by 61 · see citing works

Immunosensation: Neuroimmune Cross Talk in the Skin

Tamari, M., Heul, A. V., & Kim, B. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101719-113805 · Cited by 60 · see citing works

Strategies for precision vagus neuromodulation

Ahmed, U., Chang, Y.-C., Zafeiropoulos, S., Nasrallah, Z., Miller, L. S., & Zanos, S. P. (2022) · Bioelectronic Medicine · doi:10.1186/s42234-022-00091-1 · Cited by 60 · see citing works

Innate Immunity System in Patients With Cardiovascular and Kidney Disease

Zoccali, C., & Mallamaci, F. (2023) · Circulation Research · doi:10.1161/circresaha.122.321749 · Cited by 60 · see citing works

Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome.

Metz, C., & Pavlov, V. A. (2018) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00195.2018 · Cited by 54 · see citing works

Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases

Ramos-Martínez, I. E., Rodriguez, M. C., Cerbón, M. A., Ramos-Martínez, J. C., & Ramos-Martínez, E. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413427 · Cited by 57 · see citing works

Salivary lactoferrin as biomarker for Alzheimer's disease: Brain‐immunity interactions

Bermejo‐Pareja, F., del Ser, T., Valentí, M., la Fuente, M. D., Bartolomé, F. B., & Carro, E. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12107 · Cited by 55 · see citing works

Treating disorders across the lifespan by modulating cholinergic signaling with galantamine

Metz, C. N., & Pavlov, V. A. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15243 · Cited by 56 · see citing works

Panax notoginseng saponins and their applications in nervous system disorders: a narrative review

Qu, J., Xu, N., Zhang, J., Geng, X., & Zhang, R. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-6909 · Cited by 53 · see citing works

Transcutaneous auricular vagus nerve stimulation attenuates inflammatory bowel disease in children: a proof-of-concept clinical trial

Sahn, B. A., Pascuma, K. A., Kohn, N. E., Tracey, K. J., & Markowitz, J. F. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00124-3 · Cited by 53 · see citing works

The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy

Meade, E., & Garvey, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158574 · Cited by 53 · see citing works

Autonomic Nervous System Dysfunction in Primary Sjögren’s Syndrome

Davies, K., & Ng, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702505 · Cited by 51 · see citing works

The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response

Pavlov, V. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107794 · Cited by 49 · see citing works

Non-invasive Vagus Nerve Stimulation for COVID-19: Results From a Randomized Controlled Trial (SAVIOR I)

Tornero, C., Pastor, E., Garzando, M. D. M., Orduña-Valls, J., Forner, M. J., Bocigas, I., Cedeño, D. L., Vallejo, R., McClure, C. K., Czura, C. J., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.820864 · Cited by 51 · see citing works

Further Understanding of Neuro-Immune Interactions in Allergy: Implications in Pathophysiology and Role in Disease Progression

Konstantinou, G. Ν., Konstantinou, G., Koulias, C., Petalas, K., & Makris, M. P. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s282039 · Cited by 50 · see citing works

Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor

Li, X., Tae, H., Chu, Y., Jiang, T., Adams, D. J., & Yu, R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107792 · Cited by 50 · see citing works

The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial

Sangaleti, C. T., Katayama, K. Y., Angelis, K. D., de Moraes, T. L., de Araújo, A. A., Lopes, H. F., Camacho, C. P., Bortolotto, L. A., Michelini, L. C., Irigoyen, M. C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613979 · Cited by 50 · see citing works

Neurons Are a Primary Driver of Inflammation via Release of HMGB1

Yang, H., Andersson, J., & Brines, M. L. (2021) · Cells · doi:10.3390/cells10102791 · Cited by 48 · see citing works

Probiotics of Diverse Origin and Their Therapeutic Applications: A Review

Yadav, M., Mandeep, & Shukla, P. (2019) · Journal of the American College of Nutrition · doi:10.1080/07315724.2019.1691957 · Cited by 48 · see citing works

Regulation of Carcinogenesis by Sensory Neurons and Neuromediators

Erin, N., Shurin, G. V., Baraldi, J. H., & Shurin, M. R. (2022) · Cancers · doi:10.3390/cancers14092333 · Cited by 48 · see citing works

Development and characterization of a chronic implant mouse model for vagus nerve stimulation

Mughrabi, I. T., Hickman, J. L., Jayaprakash, N., Thompson, D., Ahmed, U., Papadoyannis, E. S., Chang, Y.-C., Abbas, A., Datta, T., Chang, E. H., et al. (2021) · eLife · doi:10.7554/elife.61270 · Cited by 47 · see citing works

Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Petruso, F., Giff, A., Milano, B. A., Rossi, M. M. D., & Saccaro, L. F. (2023) · Neuronal Signaling · doi:10.1042/ns20220077 · Cited by 51 · see citing works

Acupuncture modulates immunity in sepsis: Toward a science-based protocol

Pan, W. X., Fan, A. Y., Chen, S., & Alemi, S. F. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102793 · Cited by 49 · see citing works

Neuromorphic bioelectronic medicine for nervous system interfaces: from neural computational primitives to medical applications

Donati, E., & Indiveri, G. (2023) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/acb51c · Cited by 47 · see citing works

Control of inflammation using non-invasive neuromodulation: past, present and promise

Tynan, A., Brines, M. L., & Chavan, S. S. (2021) · International Immunology · doi:10.1093/intimm/dxab073 · Cited by 45 · see citing works

Neural circuitry and immunity

Pavlov, V. A., & Tracey, K. J. (2015) · Immunologic Research · doi:10.1007/s12026-015-8718-1 · Cited by 254 · see citing works

The Neuroimmune Communicatome in Inflammation

Olofsson, P. S., Metz, C. N., & Pavlov, V. A. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch59 · Cited by 14 · see citing works

Neural regulators of innate immune responses and inflammation

Pavlov, V. A., & Tracey, K. J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4102-3 · Cited by 174 · see citing works

Neuro-Immune Interactions in Inflammation and Autoimmunity

Terrando, N., & Pavlov, V. A. (2018) · Directory of Open access Books (OAPEN Foundation)

Mechanisms and Therapeutic Relevance of Neuro-immune Communication

Chavan, S. S., Pavlov, V. A., & Tracey, K. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.008 · Cited by 661 · see citing works