Cited by 483Bone Metabolism and DiseasesBone health and osteoporosis researchFibroblast Growth Factor Research

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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

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Montero, Aldemar, Okada, Yosuke, Tomita, Masato, Ito, Masako, Tsurukami, Hiroshi, Nakamura, Toshitaka, Doetschman, Thomas, Coffin, J. Douglas, Hurley, Marja M.·2000·Journal of Clinical Investigation

DOI 10.1172/jci8641PMC PMC300831

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Abstract

Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth and differentiation, is expressed and regulated in osteoblastic cells. To investigate the role of FGF-2 in bone, we examined mice with a disruption of the Fgf2 gene. Measurement of trabecular bone architecture of the femoral metaphysis of Fgf2(+/+) and Fgf2(-/-) adult mice by micro-CT revealed that the platelike trabecular structures were markedly reduced and many of the connecting rods of trabecular bone were lost in the Fgf2(-/-) mice. Dynamic histomorphometry confirmed a significant decrease in trabecular bone volume, mineral apposition, and bone formation rates. In addition, there was a profound decreased mineralization of bone marrow stromal cultures from Fgf2(-/-) mice. This study provides strong evidence that FGF-2 helps determine bone mass as well as bone formation.

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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Mechanisms of bone development and repair
Salhotra, A., Shah, H. N., Lévi, B., & Longaker, M. T. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00279-w · Cited by 1,302
Building strong bones: molecular regulation of the osteoblast lineage
Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,211
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
Ducy, P. F., Schinke, T., & Karsenty, G. (2000) · Science · doi:10.1126/science.289.5484.1501 · Cited by 1,137

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Authors: Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J. D., & Hurley, M. M.
Affiliations: UConn Health (US)
Nagasaki University (JP)
University of Occupational and Environmental Health Japan (JP)
University of Cincinnati (US)
University of Montana (US)
Corresponding author: Hurley, Marja M.
ORCID: Okada, Yosuke
Nakamura, Toshitaka
Hurley, Marja M.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2000-04-15
Volume: 105
Issue: 8
Pages: 1085-1093
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci8641
PMC: PMC300831
OpenAlex: W2167091901
Cited by: 483
References: 84
Citations by year: 2026: 8 · 2025: 7 · 2024: 16 · 2023: 7 · 2022: 7 · 2021: 20 · 2020: 24 · 2019: 17 · 2018: 13 · 2017: 15 · 2016: 21 · 2015: 28 · 2014: 22 · 2013: 27 · 2012: 24
FWCI: 7.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01ar046025-01a1, 7r01hl053631-05)
National Heart, Lung, and Blood Institute (HL53631)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR46025)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords: fibroblast growth factor 2, bone mass, bone formation, trabecular bone microarchitecture, osteoblasts, bone mineralization, mesenchymal stem cells, mineral apposition rate, femoral metaphysis
MeSH terms: Alkaline Phosphatase, Animals, Bone and Bones, Bone Marrow Cells, Cells, Cultured, Femur, Osteoblasts, Osteogenesis, RNA, Messenger, Skull, Tibia, Fibroblast Growth Factor 2, Mice, Knockout, Mice

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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

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