Cited by 695Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismMuscle Physiology and Disorders

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Skeletal muscle inflammation and insulin resistance in obesity

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Wu, Huaizhu, Ballantyne, Christie M.·2017·Journal of Clinical Investigation

DOI 10.1172/jci88880PMC PMC5199705

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Abstract

Obesity is associated with chronic inflammation, which contributes to insulin resistance and type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the majority of insulin-stimulated whole-body glucose disposal; thus, dysregulation of skeletal muscle metabolism can strongly influence whole-body glucose homeostasis and insulin sensitivity. Increasing evidence suggests that inflammation occurs in skeletal muscle in obesity and is mainly manifested by increased immune cell infiltration and proinflammatory activation in intermyocellular and perimuscular adipose tissue. By secreting proinflammatory molecules, immune cells may induce myocyte inflammation, adversely regulate myocyte metabolism, and contribute to insulin resistance via paracrine effects. Increased influx of fatty acids and inflammatory molecules from other tissues, particularly visceral adipose tissue, can also induce muscle inflammation and negatively regulate myocyte metabolism, leading to insulin resistance.

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1 retracted

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Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations
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The MetaboHealth score enhances insulin resistance metabotyping for targeted fat loss through personalized diets: Insights from the PERSON intervention studyPreprint
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Authors: Wu, H., & Ballantyne, C. M.
Affiliations: Houston Methodist (US)
Corresponding author: Ballantyne, Christie M.
ORCID: Wu, Huaizhu
Ballantyne, Christie M.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2017-01-03
Volume: 127
Issue: 1
Pages: 43-54
ISSN: 0021-9738 (ISSN-L)
1558-8238
DOI: 10.1172/jci88880
PMC: PMC5199705
OpenAlex: W2561422649
Cited by: 695
References: 171
Citations by year: 2026: 66 · 2025: 92 · 2024: 103 · 2023: 84 · 2022: 98 · 2021: 95 · 2020: 76 · 2019: 45 · 2018: 29 · 2017: 7
FWCI: 5.69
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association (AHA16GRNT30410012)
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL098839)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078847)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: skeletal muscle inflammation, insulin resistance, obesity, type 2 diabetes, chronic inflammation, immune cell infiltration, proinflammatory molecules, paracrine signaling, visceral adipose tissue, glucose homeostasis
MeSH terms: Animals, Diabetes Mellitus, Type 2, Glucose, Humans, Inflammation, Insulin Resistance, Myositis, Obesity, Muscle, Skeletal, Muscle Fibers, Skeletal, Intra-Abdominal Fat

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Skeletal muscle inflammation and insulin resistance in obesity

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