Intravascular hemolysis and the pathophysiology of sickle cell disease

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Items 101–200 of 746

1. Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome
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2. Safety and efficacy of mitapivat in sickle cell disease (RISE UP): results from the phase 2 portion of a global, double-blind, randomised, placebo-controlled trial
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3. Emerging pharmacotherapeutic approaches for the management of sickle cell disease
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4. Murine bone marrow mesenchymal stromal cells have reduced hematopoietic maintenance ability in sickle cell disease
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5. Sickle red blood cell‐derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor
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6. MYH9‐related disease mutations cause abnormal red blood cell morphology through increased myosin‐actin binding at the membrane
   Alyson S. Smith, Kasturi Pal, Roberta B. Nowak, Anastasiya Demenko, Carlo Zaninetti, Lydie M. Da Costa, Rémi Favier, Alessandro Pecci, Velia M. Fowler · 2019 · American Journal of Hematology
7. Hemolysis and Kidney Injury in Cardiac Surgery: The Protective Role of Nitric Oxide Therapy
   Stefano Spina, Chong Lei, Riccardo Pinciroli, Lorenzo M. Berra · 2019 · Seminars in Nephrology
8. Biomarker signatures of sickle cell disease severity
   Mengtian Du, Sarah E. Van Ness, Victor R. Gordeuk, Mehdi syed Nouraie, Sergei A. Nekhai, Mark T. Gladwin, Martin H. Steinberg, Paola Sebastiani · 2018 · Blood Cells Molecules and Diseases
9. Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
   Alexandra Gerogianni, Jordan D. Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Kerstin Sandholm, Karin Ekholt, Kristina Nilsson Ekdahl, Tom Eirik Mollnes, Camilla Mohlin et al. · 2022 · Frontiers in Immunology
10. Metabolic signatures of cardiorenal dysfunction in plasma from sickle cell patients as a function of therapeutic transfusion and hydroxyurea treatment
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11. Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems
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12. Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
    Huan Cao, Aristotelis Antonopoulos, Sadie Henderson, Heather J. Wassall, John N. Brewin, Alanna Masson, Jenna Shepherd, Gabriela Konieczny, Bhinal Patel, Maria-Louise Williams et al. · 2021 · Nature Communications
13. Arginine Therapy and Cardiopulmonary Hemodynamics in Hospitalized Children with Sickle Cell Anemia: A Prospective, Double-blinded, Randomized Placebo-controlled Clinical Trial
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14. MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease
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15. Current and Future Therapeutics for Treating Patients with Sickle Cell Disease
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16. Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL‐17/MIP‐1 β , IL‐12/VEGF, and IL‐10/IP‐10 Axis
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17. The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease
    Naja Nyffenegger, Rahima Zennadi, Natarajaswamy Kalleda, Anna Flace, Giada Ingoglia, Raphael M. Buzzi, Cédric Doucerain, Paul W. Buehler, Dominik J. Schaer, Franz Dürrenberger et al. · 2022 · Blood
18. Antioxidant nutrients and hemolysis in sickle cell disease
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19. Complement in sickle cell disease and targeted therapy: I know one thing, that I know nothing
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20. Autonomic nervous system involvement in sickle cell disease
    Thomas D. Coates, Patjanaporn Chalacheva, Lonnie K. Zeltzer, Michael C. K. Khoo · 2018 · Clinical Hemorheology and Microcirculation
21. Stimulation of eryptosis by broad-spectrum insect repellent N,N-Diethyl-3-methylbenzamide (DEET)
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22. CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat Sickle Cell Disease
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23. Sickle cell disease as a vascular disorder
    Solomon Fiifi Ofori-Acquah · 2020 · Expert Review of Hematology
24. Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice
    Oluwabukola T. Gbotosho, Maria G. Kapetanaki, Samit Ghosh, Flordeliza S. Villanueva, Solomon Fiifi Ofori-Acquah, Gregory James Kato · 2020 · Frontiers in Immunology
25. How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children
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26. Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood
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27. Redox signaling in sickle cell disease
    Deirdre Nolfi‐Donegan, Tirthadipa Pradhan‐Sundd, Kirkwood A. Pritchard, Cheryl A. Hillery · 2019 · Current Opinion in Physiology
28. Neuroimaging in Sickle Cell Disease: A Review
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29. The impact of voxelotor treatment on leg ulcers in patients with sickle cell disease
    Caterina P. Minniti, Jennifer Knight‐Madden, Margaret Eleanor Tonda, Sarah Gray, Joshua Lehrer‐Graiwer, Bart J. Biemond · 2021 · American Journal of Hematology
30. Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease
    Huiping Shi, Bojing Shao, Liang Gao, Thamizhiniyan Venkatesan, J. Michael McDaniel, Meixiang Zhou, Samuel McGee, Pengchun Yu, Jasimuddin Ahamed, Janna M. Journeycake et al. · 2022 · Proceedings of the National Academy of Sciences
31. Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease
    James E. Louie, Caitlin Anderson, Katayoun Fomani, Alonye Henry, Trevor F. Killeen, Narla Mohandas, Karina Yazdanbakhsh, John D. Belcher, Gregory M. Vercellotti, Patricia Ann Shi · 2017 · Transfusion
32. Vasculopathy in Sickle Cell Disease: From Red Blood Cell Sickling to Vascular Dysfunction
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33. Stroke in sickle cell disease and the promise of recent disease modifying agents
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34. Systematic Review of Voxelotor: A First‐in‐Class Sickle Hemoglobin Polymerization Inhibitor for Management of Sickle Cell Disease
    Jin Han, Santosh L. Saraf, Victor R. Gordeuk · 2020 · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
35. Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease
    Boris Tchernychev, Huihui Li, Sung Kyun Lee, Xin Gao, Raghunath Ramanarasimhaiah, Guang Liu, Katherine C. Hall, Sylvie G. Bernier, Juli E. Jones, Susanne C. Feil et al. · 2021 · British Journal of Pharmacology
36. Oxidative Reactions Catalyzed by Hydrogen Peroxide Produced by Streptococcus pneumoniae and Other Streptococci Cause the Release and Degradation of Heme from Hemoglobin
    Babek Alibayov, Anna Scasny, Faidad Khan, Aidan Creel, Perriann Smith, Ana G. Jop Vidal, Fa’alataitaua M. Fitisemanu, Teresita Padilla‐Benavides, Jeffrey N. Weiser, Jorge Eugenio Vidal · 2022 · Infection and Immunity
37. Osteonecrosis in sickle cell disease patients from Bahia, Brazil: a cross-sectional study
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38. Blood Impairs Viability of Fat Grafts and Adipose Stem Cells: Importance of Washing in Fat Processing
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39. Airway inflammation in sickle cell disease—A translational perspective
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40. Genetic, laboratory and clinical risk factors in the development of overt ischemic stroke in children with sickle cell disease
    André Rolim Belisário, Célia Maria Silva, Cibele Velloso‐Rodrigues, Marcos Borato Viana · 2017 · Hematology Transfusion and Cell Therapy
41. Shape oscillations of single blood drops: applications to human blood and sickle cell disease
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42. Treating sickle cell anemia: A new era dawns
    Martin H. Steinberg · 2020 · American Journal of Hematology
43. Circulating Extracellular Vesicles and Endothelial Damage in Sickle Cell Disease
    Gabrielle Lapping‐Carr, Joanna Gemel, Yifan V. Mao, Eric C. Beyer · 2020 · Frontiers in Physiology
44. Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease
    Heidi M. Schmidt, Katherine C. Wood, Sara E. Lewis, Scott A. Hahn, Xena M. Williams, Brenda McMahon, Jeffrey Baust, Shuai Sammy Yuan, Timothy N. Bachman, Yekai Wang et al. · 2020 · Arteriosclerosis Thrombosis and Vascular Biology
45. Sickle Cell Disease and CKD: An Update
    Rima S. Zahr, Santosh L. Saraf · 2023 · American Journal of Nephrology
46. Endothelial dysfunction in Sickle Cell Disease: Strategies for the treatment
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47. Impacts of oxidative stress and anti-oxidants on the development, pathogenesis, and therapy of sickle cell disease: A comprehensive review
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48. Ferroptosis as an emerging target in sickle cell disease
    Vitor Fortuna, Jaqueline Costa Lima, Gabriel F. Oliveira, Yasmin Souza Caldas de Oliveira, Bruk Getachew, Sergei A. Nekhai, Michael Aschner, Yousef Tizabi · 2024 · Current Research in Toxicology
49. Hemin-Induced Endothelial Dysfunction and Endothelial to Mesenchymal Transition in the Pathogenesis of Pulmonary Hypertension Due to Chronic Hemolysis
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50. Role of Macrophages in Sickle Cell Disease Erythrophagocytosis and Erythropoiesis
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51. cGMP modulation therapeutics for sickle cell disease
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52. Plasma hemoglobin: A method comparison of six assays for hemoglobin and hemolysis index measurement
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53. Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice
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54. Optical coherence tomography (OCT) and OCT angiography allow early identification of sickle cell maculopathy in children and correlate it with systemic risk factors
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55. P-selectin deficiency promotes liver senescence in sickle cell disease mice
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56. Sickle Cell Disease-Induced Pulmonary Hypertension: A Review of Pathophysiology, Management, and Current Literature
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57. Oxidative stress in sickle cell disease; more than a DAMP squib
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58. Prevalência da doença falciforme em adultos com diagnóstico tardio
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59. Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients
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60. Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice
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61. Stable to improved cardiac and pulmonary function in children with high-risk sickle cell disease following haploidentical stem cell transplantation
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62. Association of plasma homocysteine level with vaso-occlusive crisis in sickle cell anemia patients of Odisha, India
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63. Multiple inducers of endothelial NOS ( eNOS ) dysfunction in sickle cell disease
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64. Heme stimulates platelet mitochondrial oxidant production to induce targeted granule secretion
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65. Potential involvement of ubiquitin‐proteasome system dysfunction associated with oxidative stress in the pathogenesis of sickle cell disease
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66. Decreased erythrocyte binding of Siglec-9 increases neutrophil activation in sickle cell disease
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67. Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease
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68. Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation
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69. Therapeutic gene editing strategies using CRISPR-Cas9 for the β-hemoglobinopathies
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70. Targeting novel mechanisms of pain in sickle cell disease
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71. Overcoming challenges of venous thromboembolism in sickle cell disease treatment
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72. Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents
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73. Nitric Oxide in Post-cardiac Arrest Syndrome
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74. Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments
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75. Correlation of lipid peroxidation and nitric oxide metabolites, trace elements, and antioxidant enzymes in patients with sickle cell disease
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76. Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition
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77. Haptoglobin Genotypes Associated with Vaso-Occlusive Crisis in Sickle Cell Anemia Patients of Eastern India
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80. The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease
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85. A retrospective analysis of the hemolysis occurrence during extracorporeal membrane oxygenation in a single center
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87. Host-Derived Cytotoxic Agents in Chronic Inflammation and Disease Progression
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88. Hemolysis dictates monocyte differentiation via two distinct pathways in sickle cell disease vaso-occlusion
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89. Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait
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91. Cardiovascular phenotypes predict clinical outcomes in sickle cell disease: An echocardiography‐based cluster analysis
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92. Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
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93. Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease
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94. Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease
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97. Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients
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98. An Experimental-Computational Approach to Quantify Blood Rheology in Sickle Cell Disease
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99. Mechanistic insights into cell-free hemoglobin-induced injury during septic shock
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100. Potential Role of Soluble Toll-like Receptors 2 and 4 as Therapeutic Agents in Stroke and Brain Hemorrhage
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