Gladwin, Mark T.

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery

Nitric Oxide and Endothelin EffectsEicosanoids and Hypertension Pharmacology

Cited by 2,739

Sickle-cell disease

Rees, D. C., Williams, T. N., & Gladwin, M. T. (2010) · The Lancet

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 2,504

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Taliun, D., Harris, D. N., Kessler, M. D., Carlson, J., Szpiech, Z. A., Torres, R., Taliun, S. A. G., Corvelo, A., Gogarten, S. M., Kang, H. M., et al. (2021) · Nature

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 2,213

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 1,807

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 1,330

Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease

Gladwin, M. T., Sachdev, V., Jison, M. L., Shizukuda, Y., Plehn, J. F., Minter, K., Brown, B., Coles, W. A., Nichols, J. S., Ernst, I., et al. (2004) · New England Journal of Medicine

Hemoglobinopathies and Related DisordersPulmonary Hypertension Research and Treatments

Cited by 1,325

Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes

Kato, G. J., Gladwin, M. T., & Steinberg, M. H. (2007) · Blood Reviews

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 876

Pathophysiology of Sickle Cell Disease

Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 813

Intravascular hemolysis and the pathophysiology of sickle cell disease

Kato, G. J., Steinberg, M. H., & Gladwin, M. T. (2017) · Journal of Clinical Investigation

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 748

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

Bick, A. G., Weinstock, J. S., Nandakumar, S. K., Fulco, C. P., Bao, E. L., Zekavat, S. M., Szeto, M. D., Liao, X., Leventhal, M. J., Nasser, J., et al. (2020) · Nature

Acute Myeloid Leukemia ResearchGenetic Associations and Epidemiology

Cited by 733

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation

Nitric Oxide and Endothelin EffectsCardiac Ischemia and Reperfusion

Cited by 674

Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

Kato, G. J., McGowan, V., Machado, R. F., Little, J. A., Taylor, J., Morris, C. R., Nichols, J. S., Wang, X., Poljakovic, M., Morris, S. M., et al. (2006) · Blood

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 661

Nitrate and nitrite in biology, nutrition and therapeutics

Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., et al. (2009) · Nature Chemical Biology

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 617

The emerging biology of the nitrite anion

Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 609

Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration

Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 599

Strategies to increase nitric oxide signalling in cardiovascular disease

Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 576

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine

Cardiac Ischemia and ReperfusionNitric Oxide and Endothelin Effects

Cited by 555

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 541

Pulmonary Complications of Sickle Cell Disease

Gladwin, M. T., & Vichinsky, E. (2008) · New England Journal of Medicine

Hemoglobinopathies and Related DisordersPulmonary Hypertension Research and Treatments

Cited by 470

Role of circulating nitrite and S -nitrosohemoglobin in the regulation of regional blood flow in humans

Gladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 441

Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary

Shah, S. J., Borlaug, B. A., Kitzman, D. W., McCulloch, A. D., Blaxall, B. C., Agarwal, R., Chirinos, J. A., Collins, S., Deo, R. C., Gladwin, M. T., et al. (2020) · Circulation

Cardiovascular Function and Risk FactorsHeart Failure Treatment and Management

Cited by 436

Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology

van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 435

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

Hendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., et al. (2008) · Proceedings of the National Academy of Sciences

Hemoglobin structure and functionCardiac Ischemia and Reperfusion

Cited by 418

Pulmonary Arterial Hypertension: The Clinical Syndrome

Lai, Y.-C., Potoka, K. C., Champion, H. C., Mora, A. L., & Gladwin, M. T. (2014) · Circulation Research

Pulmonary Hypertension Research and TreatmentsVascular Anomalies and Treatments

Cited by 402