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Epigenetic regulation and therapeutic targets in the tumor microenvironment

Xie, Z., Zhou, Z., Yang, S., Zhang, S., & Shao, B. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00126-2 · Cited by 38 · see citing works

SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma

Liu, C.-L., Pan, H., Torng, P., Fan, M. H., & Mao, T. L. (2019) · Oncology Reports · doi:10.3892/or.2019.7379 · Cited by 37 · see citing works

Role of cancer‑associated fibroblasts in the resistance to antitumor therapy, and their potential therapeutic mechanisms in non‑small cell lung cancer (Review)

Chen, C., Hou, J., Yu, S., Li, W., Wang, X., Sun, H., Qin, T., Claret, F. X., Guo, H., & Liu, Z. (2021) · Oncology Letters · doi:10.3892/ol.2021.12674 · Cited by 35 · see citing works

Role of tumor microenvironment in ovarian cancer metastasis and clinical advancements

Wang, Y., Zhu, N., Liu, J., Chen, F., Song, Y., Ma, Y., Yang, Z., & Wang, D. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06508-0 · Cited by 41 · see citing works

Stress responses in stromal cells and tumor homeostasis

Vitale, I., Manic, G., Galassi, C., & Galluzzi, L. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.004 · Cited by 32 · see citing works

Role of Cancer-Associated fibroblast in the pathogenesis of ovarian Cancer: Focus on the latest therapeutic approaches

Ding, H., Zhang, J., Zhang, F., Xu, Y., Yu, Y., Liang, W., & Li, Q. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109052 · Cited by 31 · see citing works

Is routine omentectomy of grossly normal omentum helpful in surgery for ovarian cancer? A look at the tumor microenvironment and its clinical implications

Bilbao, M., Aikins, J. K., & Ostrovsky, O. (2021) · Gynecologic Oncology · doi:10.1016/j.ygyno.2020.12.033 · Cited by 31 · see citing works

Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family

Gao, P., Peng, T., Cao, C., Lin, S., Wu, P., Huang, X., Wei, J., Xi, L., Qin, Y., & Wu, P. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.595436 · Cited by 28 · see citing works

Shikonin reverses cancer-associated fibroblast-induced gemcitabine resistance in pancreatic cancer cells by suppressing monocarboxylate transporter 4-mediated reverse Warburg effect

Hu, X., Peng, X., Zhang, Y., Fan, S., Liu, X., Song, Y., Ren, S., Chen, L., Chen, Y., Wang, R., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155214 · Cited by 28 · see citing works

Stanniocalcin 1 in tumor microenvironment promotes metastasis of ovarian cancer

Yang, Y., Yin, S., Li, S., Chen, Y., & Yang, L. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s196150 · Cited by 28 · see citing works

Leptin contributes to the taxol chemoresistance in epithelial ovarian cancer

Gu, F., Zhang, H., Yao, L., Jiang, S., Lu, H., Xing, X., Zhang, C., Jiang, P., & Zhang, R. (2019) · Oncology Letters · doi:10.3892/ol.2019.10381 · Cited by 28 · see citing works

Bête Noire of Chemotherapy and Targeted Therapy: CAF-Mediated Resistance

De, P. K., Aske, J. C., Sulaiman, R. A., & Dey, N. (2022) · Cancers · doi:10.3390/cancers14061519 · Cited by 28 · see citing works

Omental metastasis as a predictive risk factor for unfavorable prognosis in patients with stage III–IV epithelial ovarian cancer

Iwagoi, Y., Motohara, T., Hwang, S., Fujimoto, K., Ikeda, T., & Katabuchi, H. (2021) · International Journal of Clinical Oncology · doi:10.1007/s10147-021-01866-3 · Cited by 27 · see citing works

Patient-Derived Primary Cancer-Associated Fibroblasts Mediate Resistance to Anti-Angiogenic Drug in Ovarian Cancers

Sulaiman, R. A., De, P. K. R., Aske, J. C., Lin, X., Dale, A., Koirala, N., Gaster, K., Espaillat, L. R., Starks, D. C., & Dey, N. (2023) · Biomedicines · doi:10.3390/biomedicines11010112 · Cited by 27 · see citing works

Cold atmospheric plasma: Novel opportunities for tumor microenvironment targeting

Dai, X., & Zhu, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5491 · Cited by 27 · see citing works

Atractylenolide-I Sensitizes Triple-Negative Breast Cancer Cells to Paclitaxel by Blocking CTGF Expression and Fibroblast Activation

Wang, M., Li, X., Zhang, M., Ye, Q.-Y., Chen, Y.-X., & Xu, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.738534 · Cited by 26 · see citing works

Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations

Schuster, S. L., Arora, S., Wladyka, C. L., Itagi, P., Corey, L., Young, D., Stackhouse, B. L., Kollath, L. A., Wu, Q. V., Corey, E., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112840 · Cited by 26 · see citing works

Identification of a cancer associated fibroblasts-related index to predict prognosis and immune landscape in ovarian cancer

Ye, Y., Zhang, S., Jiang, Y., Huang, Y., Wang, G., Zhang, M., Gui, Z., Wu, Y., Bian, G., Li, P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-48653-w · Cited by 25 · see citing works

Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options

Nunes, M., Bartosch, C., Abreu, M. H., Richardson, A., Almeida, R., & Ricardo, S. A. V. (2024) · Cells · doi:10.3390/cells13090786 · Cited by 25 · see citing works

The multifaceted contributions of cancer-associated fibroblasts to drug resistance in primary and metastatic tumors

Zhang, X., Wang, Y., Cui, W., Li, D., Song, J., Liu, Y., Liu, Y., & Yang, S. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101273 · Cited by 24 · see citing works

Strategies for Delivery of siRNAs to Ovarian Cancer Cells

Farra, R., Maruna, M., Perrone, F. M., Grassi, M., Benedetti, F. M., Maddaloni, M., Boustani, M. E., Parisi, S., Rizzolio, F., Forte, G., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11100547 · Cited by 23 · see citing works

The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment

Eckert, M. A., Orozco, C. A., Xiao, J. F., Javellana, M., & Lengyel, E. R. (2021) · Cancers · doi:10.3390/cancers13133136 · Cited by 23 · see citing works

CAFs vs. TECs: when blood feuds fuel cancer progression, dissemination and therapeutic resistance

Coursier, D., & Calvo, F. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00931-z · Cited by 23 · see citing works

Microengineered 3D Tumor Models for Anti-Cancer Drug Discovery in Female-Related Cancers

Amirghasemi, F., Adjei‐Sowah, E., Pockaj, B. A., & Nikkhah, M. (2021) · Annals of Biomedical Engineering · doi:10.1007/s10439-020-02704-9 · Cited by 22 · see citing works

Heterotypic signaling of cancer-associated fibroblasts in shaping the cancer cell drug resistance

Butti, R., Khaladkar, A., Bhardwaj, P., & Prakasam, G. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2022.72 · Cited by 23 · see citing works

Signaling within the epithelial ovarian cancer tumor microenvironment: the challenge of tumor heterogeneity

Horowitz, M. P., Esakov, E. L., Rose, P. G., & Reizes, O. (2020) · Annals of Translational Medicine · doi:10.21037/atm-2019-cm-08 · Cited by 21 · see citing works

Microfibril-associated protein 5 and the regulation of skin scar formation

Chen, H., Leonardo, T. R., Romana‐Souza, B., Shi, J., Keiser, S., Yuan, H., Altakriti, M., Ranzer, M. J., Borgogno, S. F., Mok, S. C., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35558-x · Cited by 20 · see citing works

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Roscigno, G., Scognamiglio, I., Ingenito, F., Chianese, R. V., Palma, F., Chan, A. B., & Condorelli, G. (2020) · Cancers · doi:10.3390/cancers12123744 · Cited by 19 · see citing works

A New Antitumor Direction: Tumor-Specific Endothelial Cells

Liang, J., Wang, S., Zhang, G., He, B., Bie, Q., & Zhang, B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.756334 · Cited by 18 · see citing works

Photon- and Proton-Mediated Biological Effects: What Has Been Learned?

Jumaniyazova, E. D., Смык, Д., Vishnyakova, P., Fatkhudinov, T., & Gordon, K. B. (2022) · Life · doi:10.3390/life13010030 · Cited by 18 · see citing works

Identifying gene expression patterns associated with drug-specific survival in cancer patients

Neary, B., Zhou, J., & Qiu, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-84211-y · Cited by 17 · see citing works

Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death

Veith, I., Mencattini, A., Picant, V., Serra, M., Leclerc, M., Comes, M. C., Mami‐Chouaib, F., Camonis, J., Descroix, S., Shirvani, H., et al. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008870 · Cited by 16 · see citing works

Multicompartmentalized Microvascularized Tumor-on-a-Chip to Study Tumor-Stroma Interactions and Drug Resistance in Ovarian Cancer

Plesselova, S., Calar, K., Axemaker, H., Sahly, E., Bhagia, A., Faragher, J. L., Fink, D. M., & de la Puente, P. (2024) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-024-00817-y · Cited by 17 · see citing works

Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study

Lapuente-Santana, Ó., Kant, J., & Eduati, F. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00749-w · Cited by 16 · see citing works

CAF-mediated tumor vascularization: From mechanistic insights to targeted therapies

Zhang, Z., Zhang, Q. H., & Wang, Y. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111827 · Cited by 16 · see citing works

Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma

Zhao, L., Westerhoff, M. A., Hornick, J. L., Krausz, T. N., Antic, T., Xiao, S., & Hart, J. A. L. (2019) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-019-02649-y · Cited by 15 · see citing works

Hampering Stromal Cells in the Tumor Microenvironment as a Therapeutic Strategy to Destem Cancer Stem Cells

Chung, K. P. S., Leung, R. W. H., & Lee, T. K. (2021) · Cancers · doi:10.3390/cancers13133191 · Cited by 14 · see citing works

Fibroblast-derived LPP as a biomarker for treatment response and therapeutic target in gastric cancer

Wang, H., Wu, J., Ling, R., Li, F., Yang, Q., He, J., Lei, X., Wu, C., Zhang, G., Zheng, B., et al. (2022) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2022.01.008 · Cited by 14 · see citing works

Identification of key genes and pathways related to cancer-associated fibroblasts in chemoresistance of ovarian cancer cells based on GEO and TCGA databases

Han, L., Guo, X., Du, R., Guo, K., Qi, P., & Bian, H. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-01003-2 · Cited by 14 · see citing works

Cancer-associated fibroblast cell surface markers as potential biomarkers or therapeutic targets in lung cancer

Tokhanbigli, S., Haghi, M., Dua, K., & Oliver, B. G. G. (2024) · Cancer Drug Resistance · doi:10.20517/cdr.2024.55 · Cited by 13 · see citing works

Comprehensive Analysis of 5-Methylcytosine Profiles of Messenger RNA in Human High-Grade Serous Ovarian Cancer by MeRIP Sequencing

Li, M., Zhang, Q., & Huang, X. (2021) · Cancer Management and Research · doi:10.2147/cmar.s319312 · Cited by 13 · see citing works

High glucose stimulating ECM remodeling and an inflammatory phenotype in the IPFP via upregulation of MFAP5 expression

Dong, X., Yin, J.-X., Zhang, H., & Liao, Y. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.02.077 · Cited by 13 · see citing works

DEAD-Box Helicase 27 Triggers Epithelial to Mesenchymal Transition by Regulating Alternative Splicing of Lipoma-Preferred Partner in Gastric Cancer Metastasis

Jin, Y., Yang, S., Gao, X., Chen, D., Luo, T., Su, S., Shi, Y., Yang, G., Dong, L., & Liang, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.836199 · Cited by 13 · see citing works

Single nucleotide polymorphism in the 3′ untranslated region of LPP is a risk factor for lung cancer: a case-control study

Yan, S., Sun, R., Wu, S., Jin, T., Zhang, S., Niu, F., Li, J., & Chen, M. (2019) · BMC Cancer · doi:10.1186/s12885-018-5241-5 · Cited by 13 · see citing works

miR-200-mediated inactivation of cancer-associated fibroblasts via targeting of NRP2-VEGFR signaling attenuates lung cancer invasion and metastasis

Cheon, I., Lee, S., Oh, S., & Ahn, Y. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102194 · Cited by 12 · see citing works

Cancer-associated fibroblasts in ovarian cancer: research progress

Xu, Y., Sun, D., He, J., & Yao, Q. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1504762 · Cited by 12 · see citing works

Cancer-associated fibroblasts in gynecological malignancies: are they really allies of the enemy?

Villegas‐Pineda, J. C., Ramírez-de-Arellano, A., Bueno-Urquiza, L. J., Lizarazo-Taborda, M. D. R., & Pereira-Suárez, A. L. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1106757 · Cited by 12 · see citing works

Angiotensin receptor blockers retard the progression and fibrosis via inhibiting the viability of AGTR1+CAFs in intrahepatic cholangiocarcinoma

Li, J., Wu, X. F., Ni, X., Li, Y.-X., Xu, L., Hao, X., Zhao, W., Zhu, X., & Yin, X. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1213 · Cited by 11 · see citing works

The characterization of the sensitive ovarian cancer cell lines A2780 and W1 in response to ovarian CAFs

Wojtowicz, K., & Nowicki, M. O. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.059 · Cited by 11 · see citing works

Crosstalk between stromal, immune, and ovarian cancer cells in lipid-rich tumor microenvironment exhibits proliferative features

Ma, Q., Kang, R., Xu, R., Guan, Y., Chang, S., & Li, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1614815 · Cited by 11 · see citing works

Immune Characterization of Ovarian Cancer Reveals New Cell Subtypes With Different Prognoses, Immune Risks, and Molecular Mechanisms

Cong, S., Guo, Q., Cheng, Y., He, Y., Zhao, X., Kong, C., Ning, S., & Zhang, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.614139 · Cited by 10 · see citing works

Therapeutic implications of the tumor microenvironment in ovarian cancer patients receiving PD-1/PD-L1 therapy

Wang, Y., Zhang, L., Bai, Y., Wang, L., & Ma, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1036298 · Cited by 9 · see citing works

Application Of Adoptive Immunotherapy In Ovarian Cancer

Yang, S., Yin, X., Yue, Y., & Wang, S. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s221773 · Cited by 9 · see citing works

Abstract 4184: CAF-derived MFAP5 promotes tumor angiogenesis and confers paclitaxel resistance in high-grade serous ovarian cancer

Leung, C. S., Yeung, T.-L., Yip, K., Wong, K., Sood, A. K., Birrer, M. J., & Mok, S. C. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-4184

Abstract PR-011: Role of cancer associated fibroblasts in ovarian cancer relapse

Fang, Y., Ghosh, A., Wang, J., Dasari, S., Zamarin, D., & Mitra, A. K. (2024) · Cancer Research · doi:10.1158/1538-7445.ovarian23-pr-011

Identification of key genes and pathways related to cancer-associated fibroblasts in chemoresistance of ovarian cancer cells based on GEO and TCGA databases

Han, L., Guo, X., Du, R., Guo, K., Qi, P., & Bian, H. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-01003-2 · Cited by 14 · see citing works

Abstract LT020: Cancer associated fibroblasts in the tumor microenvironment maintain ovarian cancer stem cells through non-canonical Wnt5a signaling

Fang, Y., Xiao, X., Wang, J., Dasari, S., Nephew, K. P., Zamarin, D., & Mitra, A. K. (2021) · Cancer Research · doi:10.1158/1538-7445.tme21-lt020 · Cited by 1 · see citing works

Abstract 4685: Cancer associated fibroblasts promote ovarian cancer chemoresistance by inducing cancer stem cells through Wnt signaling

Fang, Y., Aziz, M. A. A. E., Tiwari, K., & Mitra, A. K. (2019) · Cancer Research · doi:10.1158/1538-7445.am2019-4685 · Cited by 1 · see citing works