CSF 5-hydroxyindoleacetic Acid levels in suicidal schizophrenic patients
Abstract
Concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in the lumbar CSF were measured in a group of suicidal schizophrenic patients and in a matched group of nonsuicidal schizophrenic patients. The suicidal group had a significantly lower level. This finding is consistent with reports of low levels of CSF 5-HIAA in suicidal patients with other psychiatric diagnoses and suggests that low CSF 5-HIAA may be a generalized marker of aggressive behavior against the self and others.
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Reduced cerebrospinal fluid concentrations of 5-HIAA, the main serotonin metabolite, have been shown among suicide attempters, especially in those employing violent methods.
“Biochemical studies have shown reduced cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), the main serotonin metabolite, among suicide attempters, especially in those employing violent methods (23, 24).”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [23]
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- Authors
- Ninan, P. T., van Kammen, D. P., Scheinin, M., Linnoila, M., Bunney, W. E., & Goodwin, F. K.
- Venue
- American Journal of Psychiatry
- Published
- 1984-04-01
- Volume
- 141
- Issue
- 4
- Pages
- 566-569
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2231105787
- Cited by
- 219
- References
- 33
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 3 · 2020: 1 · 2016: 1 · 2015: 3 · 2013: 3 · 2012: 4
- FWCI
- 37.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- 5-hydroxyindoleacetic acid, cerebrospinal fluid, suicide, schizophrenia, serotonin metabolism, aggression, suicide risk markers
- MeSH terms
- Adult, Aggression, Mental Disorders, Female, Humans, Hydroxyindoleacetic Acid, Male, Schizophrenia, Schizophrenic Psychology, Suicide
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