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Effects of electrode placement on the efficacy of titrated, low-dose ECT
Abstract
This double-blind, random-assignment study contrasted the relative efficacy of bilateral and unilateral right ECT with a low-dose titration procedure. In 52 patients with primary major depressive disorder, bilateral ECT was markedly superior in short-term symptom reduction to unilateral right ECT. The two conditions did not differ in the duration of generalized seizures or in the number of treatments administered to achieve clinical response. The findings challenge the claim that the elicitation of generalized seizure is, in and of itself, sufficient for the antidepressant properties of ECT. Rather, a dose in excess of seizure threshold may contribute to the efficacy of ECT, particularly with a unilateral right electrode placement.
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Cited by
(2003) · The Lancet · doi:10.1016/s0140-6736(03)12705-5 · Cited by 1,706
Sackeim, H. A., Prudic, J., Devanand, D. P., Kiersky, J. E., Fitzsimons, L., Moody, B. J., McElhiney, M. C., Coleman, E. A., & Settembrino, J. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199303253281204 · Cited by 940
Sackeim, H. A., Prudic, J., Nobler, M. S., Fitzsimons, L., Lisanby, S. H., Payne, N., Berman, R. M., Brakemeier, E.-L., Perera, T., & Devanand, D. P. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.03.001 · Cited by 542
Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis
Burt, T., Lisanby, S. H., & Sackeim, H. A. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702002791 · Cited by 503
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George, M. S., Sackeim, H. A., Rush, A. J., Marangell, L. B., Nahas, Z., Husain, M. M., Lisanby, S., Burt, T., Goldman, J., & Ballenger, J. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00308-x · Cited by 461
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1987-11-01
- Volume
- 144
- Issue
- 11
- Pages
- 1449-1455
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2414885559
- Cited by
- 300
- References
- 0
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Effects of electrode placement on the efficacy of titrated, low-dose ECT. (1987). American Journal of Psychiatry. https://doi.org/10.1176/ajp.144.11.1449
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
