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Phenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders
Abstract
Sixty patients with probable atypical depression--defined as meeting Research Diagnostic Criteria for depressive illness, having reactive mood, and having one of four associated symptoms (hyperphagia, hypersomnolence, leaden feeling, and sensitivity to rejection)--took part in a study contrasting phenelzine, imipramine, and placebo. Phenelzine was found to be superior to imipramine and placebo. These results were compared to results from a sample of 120 patients with identical characteristics, except that they had more than one associated atypical symptom (full atypical syndrome). The size of the drug effect was comparable in patients with full atypical and partial atypical syndromes.
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Citations
Cited by
Sackeim, H. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00271-8 · Cited by 568
Maj, M., Stein, D. J., Parker, G., Zimmerman, M., Fava, G. A., De Hert, M., Demyttenaere, K., McIntyre, R. S., Widiger, T., & Wittchen, H. (2020) · World Psychiatry · doi:10.1002/wps.20771 · Cited by 435
Tranylcypromine versus imipramine in anergic bipolar depression
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.7.910 · Cited by 360
Hypersomnia across mood disorders: A review and synthesis
Kaplan, K. A., & Harvey, A. G. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.09.001 · Cited by 249
McNaughton, N., Kocsis, B., & Hajós, M. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee82e3 · Cited by 187
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1988-03-01
- Volume
- 145
- Issue
- 3
- Pages
- 306-311
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W78097575
- Cited by
- 198
- References
- 0
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Phenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders. https://app.cochat.ai/papers/10.1176/ajp.145.3.306
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- Phenelzine versus imipramine in the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders. (1988). American Journal of Psychiatry. https://doi.org/10.1176/ajp.145.3.306
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