The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder
Abstract
OBJECTIVE: The authors investigated the possibility of enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in posttraumatic stress disorder (PTSD) by using a low dose of dexamethasone. METHOD: Baseline blood samples were obtained at 8:00 a.m., and 0.5 mg of dexamethasone was administered to 21 male patients with PTSD and 12 normal age-comparable men at 11:00 p.m. Cortisol and dexamethasone levels were measured 9 and 17 hours after dexamethasone administration. RESULTS: After correction for differences in dexamethasone levels, the PTSD patients showed greater suppression of cortisol in response to dexamethasone than did the normal subjects. This was true even in patients meeting concurrent diagnostic criteria for major depression. CONCLUSIONS: The data support earlier studies showing that HPA abnormalities in PTSD are different from those seen in depression and suggest that the low-dose dexamethasone suppression test may be a potentially useful tool for differentiating the two syndromes and further exploring differences in their pathophysiology.
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“Enhanced ASR and HPA-negative feedback have been reliably observed in patients with PTSD (Shalev et al, 1992;Yehuda et al, 1993;Orr et al, 1997).”
From Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress (2012) · cites this paper as Yehuda et al, 1993
In the citing paper
“Enhanced ASR and HPA-negative feedback have been reliably observed in patients with PTSD (Shalev et al, 1992;Yehuda et al, 1993;Orr et al, 1997).”
From Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress (2012) · cites this paper as Yehuda et al, 1993
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Flagged first, then by citations
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Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688
Post-Traumatic Stress Disorder
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Self-citationGlucocorticoids, prenatal stress and the programming of disease
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Metadata
- Authors
- Yehuda, R., Southwick, S. M., Krystal, J. H., Bremner, J. D., Charney, D. S., & Mason, J. W.
- Affiliations
- Yale University (US)
- Venue
- American Journal of Psychiatry
- Published
- 1993-01-01
- Volume
- 150
- Issue
- 1
- Pages
- 83-86
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W49144085
- Cited by
- 517
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 16 · 2019: 11 · 2018: 21 · 2017: 21 · 2016: 16 · 2015: 21 · 2014: 5 · 2013: 15 · 2012: 20
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03mh049536-02)
- National Institute of Mental Health (MH-49536)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- post-traumatic stress disorder, dexamethasone suppression test, cortisol, hypothalamic-pituitary-adrenal axis, negative feedback sensitivity, major depressive disorder, differential diagnosis, glucocorticoid receptor sensitivity
- MeSH terms
- Adult, Depressive Disorder, Dexamethasone, Diagnosis, Differential, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic
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