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[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder
Abstract
OBJECTIVE: The authors examined whether subjects with Tourette's disorder have greater than normal striatal dopamine transporter densities, as suggested by previous post-mortem findings. METHOD: Single photon emission computed tomography (SPECT) and [123I]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([123I]beta-CIT) were used to assess dopamine transporter levels in five adult patients with Tourette's disorder and five age- and gender-matched healthy comparison subjects. RESULTS: Striatal [123I]beta-CIT binding was a mean of 37% (range = 6%-79%) higher in the subjects with Tourette's disorder than in the comparison subjects, and each Tourette's disorder patient had a higher level than his or her paired comparison subject. CONCLUSIONS: These findings corroborate post-mortem results and support the hypothesis of a dysregulation in presynaptic dopamine function in Tourette's disorder.
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Cited by
Plasma membrane monoamine transporters: structure, regulation and function
Torres, G. E., Gainetdinov, R. R., & Caron, M. G. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1008 · Cited by 939
Recent advances in Tourette syndrome research
Albin, R. L., & Mink, J. W. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.01.001 · Cited by 478
The Dopamine Transporter and Attention-Deficit/Hyperactivity Disorder
Madras, B. K., Miller, G. M., & Fischman, A. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.011 · Cited by 393
Basal ganglia dysfunction in Tourette’s syndrome: a new hypothesis
Mink, J. W. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00262-4 · Cited by 357
Stein, D. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09620-4 · Cited by 352
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1995-09-01
- Volume
- 152
- Issue
- 9
- Pages
- 1359-1361
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2405556557
- Cited by
- 224
- References
- 0
- FWCI
- 19.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- [123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder. (1995). American Journal of Psychiatry. https://doi.org/10.1176/ajp.152.9.1359
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