Recent advances in Tourette syndrome research
Abstract
Tourette syndrome (TS) is a developmentally regulated neurobehavioral disorder characterized by involuntary, stereotyped, repetitive movements. Recent anatomical and neuroimaging studies have provided evidence for abnormal basal ganglia and dopaminergic function in TS. Basic research on striatal inhibitory mechanisms and dopaminergic function complements the recent neuroimaging and anatomical data. Parallel studies of basal ganglia participation in the normal performance and learning of stereotyped repetitive behaviors or habits has provided additional insight. These lines of research have provided new pieces to the TS puzzle, and their increasing convergence is showing how those pieces can be put together.
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There is increasing evidence for frontal-striatal dysfunction in TS.
“There is increasing evidence for frontal–striatal dysfunction in TS [for reviews, see Albin and Mink (2006) and Felling and Singer (2011)].”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Albin and Mink (2006)
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Tourette syndrome and comorbid ADHD: causes and consequences
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Motor-Cortical Interaction in Gilles de la Tourette Syndrome
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The computational neurology of movement under active inference
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- Authors
- Albin, R. L., & Mink, J. W.
- Affiliations
- University of Michigan (US)
- University of Rochester Medicine (US)
- Corresponding author
- Mink, Jonathan W.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 29
- Issue
- 3
- Pages
- 175-182
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2060469305
- Cited by
- 478
- References
- 112
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 20 · 2021: 20 · 2020: 37 · 2019: 19 · 2018: 19 · 2017: 26 · 2016: 24 · 2015: 33 · 2014: 29 · 2013: 31 · 2012: 27
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Tourette syndrome, basal ganglia, dopaminergic activity, habit, neurobehavioral disorders, neuroimaging
- MeSH terms
- Basal Ganglia, Dopamine, Tourette Syndrome, Humans, Magnetic Resonance Imaging, Organ Size, Research, Tics
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