The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study
Abstract
OBJECTIVE: The purpose of this study was to determine the dopamine D2 receptor occupancy induced by low-dose haloperidol treatment in a prospective trial. METHOD: Seven patients with schizophrenia were treated with 2 mg/day of haloperidol for 2 weeks, and D2 receptor occupancy was measured by [11C]raclopride and positron emission tomography. RESULTS: The patients showed high levels of D2 occupancy (53%-74%); five of them showed substantial clinical improvement, and none showed important side effects. CONCLUSIONS: The findings demonstrate that low doses of haloperidol induce D2 receptor occupancies that are in the putative therapeutic range. In combination with recent empirical trials, these findings should encourage clinicians to initiate treatment of psychotic episodes with low (2-4 mg haloperidol equivalent) doses of typical neuroleptics, particularly for first-episode patients.
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Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Farde, L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070032005 · Cited by 1,419
Nordström, A.-L., Farde, L., Wiesel, F.-A., Forslund, K., Pauli, S., Halldin, C., & Uppfeldt, G. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90288-o · Cited by 527
Farde, L., Eriksson, L., Blomquist, G., & Halldin, C. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.98 · Cited by 448
McEvoy, J. P. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320063009 · Cited by 381
148th Annual Meeting of the American Psychiatric Association
(1996) · European Addiction Research · doi:10.1159/000319611 · Cited by 259
Kapur, S., Remington, G., Zipursky, R. B., Wilson, A. A., & Houle, S. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02037-j · Cited by 229
Dopamine Receptor Occupancy and Plasma Haloperidol Levels
Wolkin, A., Brodie, J. D., Barouche, F., Rotrosen, J., Wolf, A. P., Smith, M., Fowler, J., & Cooper, T. B. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810050096021 · Cited by 99
Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage
Seeman, P. M. (1990) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1990.tb05280.x · Cited by 95
Further evidence of a dose-response threshold for haloperidol in psychosis
Stone, C. K., Garve, D. L., Griffith, J., Hirschowitz, J., & Bennett, J. E. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1210 · Cited by 54
Cited by
Kapur, S., Zipursky, R., Jones, C., Remington, G., & Houle, S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.4.514 · Cited by 1,090
Kahn, R. S., Fleischhacker, W. W., Boter, H., Davidson, M., Vergouwe, Y., Keet, I. P., Gheorghe, M. D., Rybakowski, J. K., Galderisi, S., Libiger, J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60486-9 · Cited by 1,088
Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988
Atypical antipsychotics: Mechanism of action
Seeman, P. (2002) · The Canadian Journal of Psychiatry · doi:10.1177/070674370204700106 · Cited by 899
Delirium in the intensive care unit
Girard, T. D., Pandharipande, P. P., & Ely, E. W. (2008) · Critical Care · doi:10.1186/cc6149 · Cited by 622
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1996-07-01
- Volume
- 153
- Issue
- 7
- Pages
- 948-950
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W58194748
- Cited by
- 252
- References
- 10
- FWCI
- 17.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
