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Cited by 504

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A Novel Augmentation Strategy for Treating Resistant Major Depression

Shelton, Richard C., Tollefson, Gary D., Tohen, Mauricio, Stahl, Stephen, Gannon, Kimberley S., Jacobs, Thomas G., Buras, William R., Bymaster, Frank P., Zhang, Wei, Spencer, Kimberley A., Feldman, Peter D., Meltzer, Herbert Y.·2001·American Journal of Psychiatry
DOI 10.1176/appi.ajp.158.1.131
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Abstract

OBJECTIVE: Treatment-resistant depression is a significant public health concern; drug switching or augmentation often produce limited results. The authors hypothesized that fluoxetine could be augmented with olanzapine to successfully treat resistant depression. METHOD: An 8-week double-blind study was conducted with 28 patients who were diagnosed with recurrent, nonbipolar, treatment-resistant depression without psychotic features. Subjects were randomly assigned to one of three groups: olanzapine plus placebo, fluoxetine plus placebo, or olanzapine plus fluoxetine. RESULTS: Fluoxetine monotherapy produced minimal improvement on various scales that rate severity of depression. The benefits of olanzapine monotherapy were modest. Olanzapine plus fluoxetine produced significantly greater improvement than either monotherapy on one measure and significantly greater improvement than olanzapine monotherapy on the other measures after 1 week. There were no significant differences between treatment groups on extrapyramidal measures nor significant adverse drug interactions. CONCLUSIONS: Olanzapine plus fluoxetine demonstrated superior efficacy for treating resistant depression compared to either agent alone.

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Research works printed but not linked: 16

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  12. Tollefson GD, Beasley CM Jr, Tamura RN, Tran PV, Potvin JH: Blind, controlled, long-term study of the comparative incidence of treatment-emergent tardive dyskinesia with olanzapine or haloperidol. Am J Psychiatry 1997; 154:1248–1254 · DOI · Paper page
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  15. Zhang W, Perry WK, Wong DT, Potts BD, Bao J, Tollefson GD, Bymaster FP: Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology 2000; 23:250–262 · DOI
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Cited by

Metadata

Authors
Shelton, R. C., Tollefson, G. D., Tohen, M., Stahl, S., Gannon, K. S., Jacobs, T. G., Buras, W. R., Bymaster, F. P., Zhang, W., Spencer, K. A., Feldman, P. D., & Meltzer, H. Y.
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2001-01-01
Volume
158
Issue
1
Pages
131-134
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.158.1.131
OpenAlex
W2114693958
Cited by
504
References
2
FWCI
28.15
Type
journal article
Language
en
Open access
closed

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