The Human Genome: Mutations
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The Met allele encodes a less active COMT enzyme, resulting in lower COMT activity and higher levels of prefrontal dopamine.
“The Met allele encodes for a less active COMT enzyme, resulting in lower COMT activity, and, as a result, higher levels of prefrontal dopamine 89.”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [89]
Because dopamine reuptake proteins are sparse in the PFC but not in mesolimbic regions, the COMT enzyme can terminate dopaminergic action in prefrontal synapses, exerting a comparably large effect in the PFC.
“Because dopamine reuptake proteins are sparse in the PFC but not in mesolimbic regions, the COMT enzyme can terminate dopaminergic action in prefrontal synapses, thus exerting a comparably large effect in the PFC 89”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [89]
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Resilience in mental health: linking psychological and neurobiological perspectives.
Rutten, B. P. F., Hammels, C., Geschwind, N., Menne‐Lothmann, C., Pishva, E., Schruers, K., van den Hove, D., Kenis, G., van Os, J., & Wichers, M. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12095 · Cited by 418 · see citing works
Food insufficiency and women's mental health: Findings from a 3-year panel of welfare recipients
Heflin, C. M., Siefert, K., & Williams, D. R. (2005) · Social Science & Medicine · doi:10.1016/j.socscimed.2005.04.014 · Cited by 392 · see citing works
Variation in dopamine genes influences responsivity of the human reward system
Dreher, J.-C., Kohn, P., Kolachana, B., Weinberger, D. R., & Berman, K. F. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805517106 · Cited by 376 · see citing works
Self-citationCatechol- <i>O</i> -Methyltransferase Genotype and Dopamine Regulation in the Human Brain
Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02008.2003 · Cited by 325 · see citing works
“, 2000), and only prefrontal cortical function is affected by COMT genotype (Egan et al., 2002).”
BackgroundSelf-citationCatechol‐ O ‐methyltransferase and Its Inhibitors in Parkinson's Disease
Bonifácio, M. J., Palma, P. N., Almeida, L., & Soares-da-Silva, P. (2007) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2007.00020.x · Cited by 201 · see citing works
“COMT has also been suggested to play a relevant role in modulating prefrontal dopamine neurotransmission (Akil et al. 2003; Bilder et al. 2004; Egan et al. 2002; Huotari et al. 2002).”
BackgroundPlanning ability in Parkinson's disease is influenced by the COMT val 158 met polymorphism
Foltynie, T., Goldberg, T. E., Lewis, S. J. G., Blackwell, A. D., Kolachana, B. S., Weinberger, D. R., Robbins, T. W., & Barker, R. A. (2004) · Movement Disorders · doi:10.1002/mds.20118 · Cited by 120 · see citing works
“1 0 (0) 1 (1) 0 (0) 1 2 1 (2) 2 (1) 1 (1) 4 3 1 (2) 3 (2) 3 (4) 7 4 1 (2) 4 (3) 3 (4) 8 5 1 (2) 3 (2) 3 (4) 7 6 4 (7) 10 (6) 6 (8) 20 7 4 (7) 8 (5) 8 (11) 20 8 6 (10) 20 (13) 10 (14) 36 9 5 (8) 23 (15) 4 (5) 32 10 10 (17) 18 (12) 7 (10) 35 11 9 (15) 18 (12) 9 (12) 36 12 5 (8) 19 (12) 5 (7) 29 13 7 (12) 10 (6) 6 (8) 23…”
Self-citationMeeting risk with resilience: high daily life reward experience preserves mental health
Geschwind, N., Peeters, F., Jacobs, N., Delespaul, P., Derom, C., Thiery, E., van Os, J., & Wichers, M. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01525.x · Cited by 115 · see citing works
Li, B., Arime, Y., Hall, F. S., Uhl, G. R., & Sora, I. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.11.036 · Cited by 111 · see citing works
“Dopamine agonists can improve short-term spatial memory in human volunteers (Mehta et al., 2001), in ways that are postulated to involve frontal cortex (Egan et al 2002).”
BackgroundEpigenetic mechanisms in mood disorders: Targeting neuroplasticity
Fass, D. M., Schroeder, F. A., Perlis, R. H., & Haggarty, S. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.041 · Cited by 62 · see citing works
Hunfeld, N., Westerman, E. M., Boswijk, D. J., de Haas, J. A. M., van Putten, M. J. A. M., & Touw, D. J. (2006) · Therapeutic Drug Monitoring · doi:10.1097/01.ftd.0000185770.44502.51 · Cited by 50 · see citing works
Imaging Phenotypes and Genotypes in Schizophrenia
Turner, J. A., Smyth, P., Macciardi, F. M., Fallon, J. H., Kennedy, J. L., & Potkin, S. G. (2006) · Neuroinformatics · doi:10.1385/ni:4:1:21 · Cited by 34 · see citing works
“2, has been linked to schizophrenia previously (Weinberger et al., 2001; Egan et al., 2002; Egan et al., 2001b).”
BackgroundGenetically mediated brain abnormalities in schizophrenia
Seidman, L. J., & Wencel, H. E. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0030-4 · Cited by 27 · see citing works
“Conversely, the load of low-activity COMT met in probands with schizophrenia, their unaffected siblings, and control individuals was associated with enhanced cognitive performance on the Wisconsin Card Sort Test of executive function (explained 4% of the variance in frequency of perseverative errors [P=0.001]) [70,71…”
BackgroundInfluentialLOW‐DOSE HALOPERIDOL–ASSOCIATED QTC PROLONGATION
Stepkovitch, K., Bahn, C. H., & Gupta, R. R. N. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01901.x · Cited by 12 · see citing works
Recorded psychiatric comorbidity with bipolar disorder – A Finnish hospital discharge register study
Sorvaniemi, M., & Hintikka, J. J. (2005) · Nordic Journal of Psychiatry · doi:10.1080/08039480500360773 · Cited by 9 · see citing works
Degen, C., Zschocke, J., Toro, P., Sattler, C., Wahl, H., Schönknecht, P., & Schröder, J. (2015) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000439585 · Cited by 9 · see citing works
Opicapone Sulfation: Sulfotransferase Isoforms Characterization
Lopes, C. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/wryn-4b60 · Cited by 1 · see citing works
On social cognition : vulnerability and symptoms in psychosis
Versmissen, D. (2009) · doi:10.26481/dis.20090508dv
Opicapone Sulfation: Sulfotransferase
Lopes, C. F. (2013)
Kenis, G., Schlütter, A., & Rutten, B. P. F. (2017) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2052-3_11
5.1.2 Mentale weerbaarheid en veerkracht
Klingenberg, B., Vermetten, E. H. G. J. M., & Rutten, B. P. F. (2017) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2052-3_12
- Authors
- Egan, M., Goldman, D., & Weinberger, D.
- Venue
- American Journal of Psychiatry
- Published
- 2002-01-01
- Volume
- 159
- Issue
- 1
- Pages
- 12-12
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2106057716
- Cited by
- 20
- References
- 0
- Citations by year
- 2017: 2 · 2015: 1 · 2013: 4
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- human genome, genetic mutations, genetic variation, psychiatric genetics
- MeSH terms
- Alleles, Catechol O-Methyltransferase, Chromosomes, Human, Pair 22, Frontal Lobe, Genotype, Humans, Magnetic Resonance Imaging, Memory, Short-Term, Schizophrenia, Mutation, Missense, Imaging, Three-Dimensional
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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