The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Glutamate and Glutamine in the Anterior Cingulate and Thalamus of Medicated Patients With Chronic Schizophrenia and Healthy Comparison Subjects Measured With 4.0-T Proton MRS
Abstract
OBJECTIVE: This in vivo (1)H magnetic resonance spectroscopy study examined levels of glutamate, glutamine, and N-acetylaspartate in medicated patients with chronic schizophrenia. METHOD: Localized in vivo (1)H spectra were acquired at 4.0 T from the left anterior cingulate and thalamus of 21 patients with schizophrenia and 21 comparable healthy volunteers. RESULTS: Significantly lower levels of glutamine and glutamate were found in the left anterior cingulate cortex of patients with schizophrenia than in the healthy volunteers. For the schizophrenia patients, the glutamine level in the left thalamus was found to be higher than normal, and there was a significant negative correlation between N-acetylaspartate level and duration of positive symptoms. CONCLUSIONS: Since previous studies have found higher than normal levels of glutamine in the left anterior cingulate of never-treated patients, decreased levels of these metabolites in chronic patients could be related to neurodegeneration or the effects of chronic medication.
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Self-citationClinical Handbook of Psychotropic Drugs
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Cited by
Glutamate and dopamine in schizophrenia: An update for the 21 st century
Howes, O., McCutcheon, R., & Stone, J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114563634 · Cited by 702
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457
Merritt, K., Egerton, A., Kempton, M. J., Taylor, M. J., & McGuire, P. K. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0442 · Cited by 367
Rowland, L. M., Bustillo, J. R., Mullins, P. G., Jung, R. E., Lenroot, R., Landgraf, E., Barrow, R., Yeo, R., Lauriello, J., & Brooks, W. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.394 · Cited by 304
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Metadata
- Authors
- Théberge, J., Al-Semaan, Y., Williamson, P. C., Menon, R. S., Neufeld, R. W. J., Rajakumar, N., Schaefer, B., Densmore, M., & Drost, D. J.
- Venue
- American Journal of Psychiatry
- Published
- 2003-12
- Volume
- 160
- Issue
- 12
- Pages
- 2231-2233
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1976057168
- Cited by
- 269
- References
- 13
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Théberge, J., Al-Semaan, Y., Williamson, P. C., Menon, R. S., Neufeld, R. W. J., Rajakumar, N., Schaefer, B., Densmore, M., & Drost, D. J. (2003). Glutamate and Glutamine in the Anterior Cingulate and Thalamus of Medicated Patients With Chronic Schizophrenia and Healthy Comparison Subjects Measured With 4.0-T Proton MRS. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.160.12.2231
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