The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Autistic Social Impairment in the Siblings of Children With Pervasive Developmental Disorders
Abstract
OBJECTIVE: Sibling recurrence risk in autism has been estimated to be approximately 10%. This study investigated subsyndromal autistic impairments among siblings of probands with pervasive developmental disorders. METHOD: The authors used the Social Responsiveness Scale to obtain quantitative assessments of autistic social impairment in three groups of proband-sibling pairs: 1) autistic children from multiple-incidence families and their closest in age nonautistic brothers (N=49 pairs); 2) children with any pervasive developmental disorder, including autism, and their closest-in-age brothers (N=100 pairs), and 3) children with psychopathology unrelated to autism and their closest-in-age brothers (N=45 pairs). RESULTS: Sibling Social Responsiveness Scale scores were continuously distributed and substantially elevated for both the autistic and pervasive developmental disorder groups. Highest scores (i.e., greatest impairment) were seen among siblings of autistic probands from multiple-incidence families, followed by siblings of probands with any pervasive developmental disorder, then siblings of probands with psychopathology unrelated to autism. CONCLUSIONS: Taken together with previous findings, these results support the notion that genetic susceptibility factors responsible for common, subsyndromal social impairments may be related to the causes of categorically defined pervasive developmental disorders.
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In the citing paper
“Likewise, there is accumulating evidence that HR siblings from multiplex families exhibit higher levels of ASD-related characteristics17,19,20 than do HR siblings who have a single older sibling with an ASD.”
From Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age (2013) · cites this paper as [20]
In the citing paper
“The composition of this class is consistent with previous research indicating that a range of ASD-related behavioral features is present in low-risk as well as high-risk children.20,43,44”
From Beyond Autism: A Baby Siblings Research Consortium Study of High-Risk Children at Three Years of Age (2013) · cites this paper as [20]
In the citing paper
“Similarly, autistic-like social impairment clearly is heritable [20] and increased in unaffected parents and children of autistic probands [21].”
From Genetics of autism spectrum disorders (2011) · cites this paper as [21]
In the citing paper
“However, findings from a study using the social responsiveness scale, an instrument similar to the CSBQ, do suggest so (Constantino et al. 2006).”
From PDD symptoms in ADHD, an independent familial trait? (2009) · cites this paper as Constantino et al. 2006
Citations
Cites
Autistic Traits in the General Population: A Twin Study
Constantino, J. N., & Todd, R. D. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.524 · Cited by 1,317
Self-citationIntergenerational transmission of subthreshold autistic traits in the general population
Constantino, J. N., & Todd, R. D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.014 · Cited by 519
Self-citationThe factor structure of autistic traits
Constantino, J. N., Gruber, C. P., Davis, S., Hayes, S., Passanante, N., & Przybeck, T. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00266.x · Cited by 370
Self-citationLauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00391.x · Cited by 359
Variable Expression of the Autism Broader Phenotype: Findings from Extended Pedigrees
Pickles, A. R., Starr, E., Kazak, S., Bolton, P., Papanikolaou, Κ., Bailey, A. J., Goodman, R., & Rutter, M. L. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00634 · Cited by 294
Personality traits of the relatives of autistic probands
Murphy, M. P., Bolton, P., Pickles, A. R., Fombonne, E. J., Piven, J., & Rutter, M. L. (2000) · Psychological Medicine · doi:10.1017/s0033291799002949 · Cited by 246
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Autism risk factors: genes, environment, and gene-environment interactions
Chaste, P., & Leboyer, M. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/pchaste · Cited by 807
Genetics of autism spectrum disorders
Geschwind, D. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.003 · Cited by 696
The Broad Autism Phenotype Questionnaire
Hurley, R. S. E., Losh, M. C., Parlier, M., Reznick, J. S., & Piven, J. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0299-3 · Cited by 718
Hoekstra, R. A., Bartels, M., Cath, D. C., & Boomsma, D. I. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0538-x · Cited by 651
Autism spectrum disorders and autistic traits: A decade of new twin studies
Ronald, A., & Hoekstra, R. A. (2011) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31159 · Cited by 616
Metadata
- Authors
- Constantino, J. N., Lajonchere, C., Lutz, M., Gray, T., Abbacchi, A., McKenna, K., Singh, D., & Todd, R. D.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- American Journal of Psychiatry
- Published
- 2006-02
- Volume
- 163
- Issue
- 2
- Pages
- 294-296
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2157447287
- Cited by
- 294
- References
- 6
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 13 · 2016: 20 · 2015: 16 · 2014: 21 · 2013: 19 · 2012: 24
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 042541-01, R01HD042541)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- pervasive developmental disorders, autism spectrum disorder, siblings, social dysfunction, Social Responsiveness Scale, recurrence risk, genetic susceptibility, psychopathology
- MeSH terms
- Autistic Disorder, Mental Disorders, Child, Child Development Disorders, Pervasive, Family, Female, Humans, Male, Parents, Psychometrics, Surveys and Questionnaires, Social Adjustment, Teaching, Incidence, Genetic Predisposition to Disease, Siblings
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