The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Psychiatric Manifestations of Paraneoplastic Disorders
Abstract
Paraneoplastic disorders of the CNS result from immune responses to neuronal proteins expressed by tumors found elsewhere in the body. Limbic encephalitis, one of the most common manifestations of paraneoplastic disorders, is characterized by rapid onset of psychiatric and neurological symptoms that often culminate in severe neurological deterioration. Recent work has described paraneoplastic syndromes with prominent, and sometimes isolated, psychiatric symptoms for which patients are fi rst seen by a psychiatrist. Here the authors review the existing literature on psychiatric and behavioral manifestations of paraneoplastic disorders, the cellular mechanisms underlying these syndromes, and current treatment and outcomes. They also discuss the broad behavioral findings that highlight the need for psychiatrists to be aware of initial presentations of paraneoplastic disorders.
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Metadata
- Authors
- Kayser, M. S., Kohler, C. G., & Dalmau, J.
- Affiliations
- University of Pennsylvania (US)
- Venue
- American Journal of Psychiatry
- Published
- 2010-09
- Volume
- 167
- Issue
- 9
- Pages
- 1039-1050
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2145155354
- Cited by
- 129
- References
- 90
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 9 · 2022: 10 · 2021: 2 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 13
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA89054-06A2, R01CA089054, R01CA107192)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- paraneoplastic syndrome, psychiatric symptoms, behavioral manifestations, limbic encephalitis, autoimmune encephalitis, tumor-associated immune response, neurological deterioration, psychiatric treatment
- MeSH terms
- Autoantibodies, Autoimmune Diseases, Mental Disorders, Diagnosis, Differential, Humans, Nerve Tissue Proteins, Paraneoplastic Syndromes, Nervous System, Limbic Encephalitis, ELAV Proteins
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