AMPA receptor trafficking at excitatory synapses
Open accessAbstract
Excitatory synapses in the CNS release glutamate, which acts primarily on two sides of ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the postsynaptic depolarization that initiates neuronal firing, whereas NMDA receptors initiate synaptic plasticity. Recent studies have emphasized that distinct mechanisms control synaptic expression of these two receptor classes. Whereas NMDA receptor proteins are relatively fixed, AMPA receptors cycle synaptic membranes on and off. A large family of interacting proteins regulates AMPA receptor turnover at synapses and thereby influences synaptic strength. Furthermore, neuronal activity controls synaptic AMPA receptor trafficking, and this dynamic process plays a key role in the synaptic plasticity that is thought to underlie aspects of learning and memory.
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Controlled addition and removal of AMPA-type glutamate receptors from the postsynaptic density underlies changes in synaptic strength during learning and memory formation.
“Controlled addition and removal of AMPA-type glutamate receptors from the postsynaptic density is believed to underlie the changes in synaptic strength during learning and memory formation (Malinow and Malenka, 2002; Sheng and Kim, 2002; Bredt and Nicoll, 2003; Collingridge et al., 2004).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Bredt and Nicoll, 2003
NMDAR-dependent LTD involves clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs).
“NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of LTD, involves a rise in postsynaptic Ca2+ concentration, activation of a serine-threonine protein phosphatase cascade, and clathrin-dependent rapid endocytosis of AMPA receptors (AMPARs) [1]–[10].”
From Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD (2009) · cites this paper as [2]
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- Authors
- Bredt, D. S., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Bredt, David S
- Nicoll, Roger A
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 40
- Issue
- 2
- Pages
- 361-379
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1995680954
- Cited by
- 1,150
- References
- 14
- Citations by year
- 2026: 19 · 2025: 20 · 2024: 26 · 2023: 19 · 2022: 22 · 2021: 27 · 2020: 31 · 2019: 28 · 2018: 33 · 2017: 35 · 2016: 38 · 2015: 38 · 2014: 49 · 2013: 55 · 2012: 57
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- AMPA receptors, receptor trafficking, excitatory synapses, synaptic plasticity, NMDA receptor, glutamate receptors, activity-dependent regulation, learning and memory, synaptic efficacy
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Humans, Molecular Sequence Data, Synapses, Receptors, AMPA, Excitatory Postsynaptic Potentials, Protein Transport
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