The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
All-Cause Mortality in Women With Severe Postpartum Psychiatric Disorders
Open accessAbstract
OBJECTIVE: The postpartum period is associated with a high risk of psychiatric episodes. The authors studied mortality in women with first-onset severe psychiatric disorders following childbirth and compared their mortality rates with those in women from the background population including other female psychiatric patients (mothers and childless women). METHOD: In a register-based cohort study with linked information from Danish population registers, the authors identified women with first psychiatric inpatient or outpatient contacts 0-3 months postpartum. The main outcome measure was mortality rate ratios (MRRs): deaths from natural causes (diseases and medical conditions) or unnatural causes (suicides, accidents, and homicides). The cohort included 1,545,857 women representing 68,473,423 person-years at risk. RESULTS: In total, 2,699 women had first-onset psychiatric disorders 0-3 months postpartum, and 96 of these died during follow-up. Women with postpartum psychiatric disorders had a higher MRR (3.74; 95% CI=3.06-4.57) than non-postpartum-onset mothers (MRR=2.73; 95% CI=2.67-2.79) when compared with mothers with no psychiatric history. However, childless women with psychiatric diagnoses had the highest MRR (6.15; 95% CI=5.94-6.38). Unnatural cause of death represented 40.6% of fatalities among women with postpartum psychiatric disorders, and within the first year after diagnosis, suicide risk was drastically increased (MRR=289.42; 95% CI=144.02-581.62) when compared with mothers with no psychiatric history. CONCLUSIONS: Women with severe postpartum psychiatric disorders had increased MRRs compared with mothers without psychiatric diagnoses, and the first year after diagnosis represents a time of particularly high relative risk for suicide in this vulnerable group.
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Citations
Cites
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The Danish Civil Registration System
Pedersen, C. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810387965 · Cited by 4,713 · cited 4×
“We used the CRS registry in the present study to identify members of the cohort.”
InfluentialThe Danish National Patient Register
Lynge, E., Sandegaard, J. L., & Rebolj, M. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811401482 · Cited by 3,968 · cited 2×
“To assess the interaction of comorbid alcohol and substance abuse among the women in the cohort, we combined information from the Danish National Patient Register (23) and the Danish Psychiatric Central Register (18) using the following codes: alcohol: ICD-8: 291, 303, 570, 57100, 57110, 57300, 57301, 57710, 979, 980;…”
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“Severe postpartum psychiatric disorders can have serious implications for the women, children, and families affected (7, 8).”
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Chesney, E., Goodwin, G. M., & Fazel, S. (2014) · World Psychiatry · doi:10.1002/wps.20128 · Cited by 2,115
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“Thus, the group of childless women with psychiatric diagnoses in our cohort likely comprises the most severely mentally ill patients, who also represent the group with the worst overall prognosis (32, 33).”
BackgroundThe Danish Register of Causes of Death
Helweg‐Larsen, K. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494811399958 · Cited by 1,735 · cited 2×
“The Danish Register of Causes of Death (22) was computerized in 1970 andprovides data on all causes of death for Danish citizenswhodie inDenmark.”
The Danish Psychiatric Central Research Register
Mors, O., Perto, G. P., & Mortensen, P. B. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810395825 · Cited by 1,589 · cited 4×
“Somewomencategorizedaswomen 640 ajp.psychiatryonline.org Am J Psychiatry 173:6, June 2016 in the nondiseased background population (mothers with no psychiatric history and nonmothers with no psychiatric history) in this study might have undergone treatment for mild to moderate psychiatric symptoms at their general pra…”
MethodInfluentialNon-psychotic mental disorders in the perinatal period
Howard, L. M., Molyneaux, E., Dennis, C.-L., Rochat, T., Stein, A., & Milgrom, J. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61276-9 · Cited by 1,328
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Cited by
Sorted by citations
Perinatal mental health: a review of progress and challenges
Howard, L. M., & Khalifeh, H. (2020) · World Psychiatry · doi:10.1002/wps.20769 · Cited by 1,118
Meltzer-Brody, S., Colquhoun, H., Riesenberg, R., Epperson, C. N., Deligiannidis, K. M., Rubinow, D. R., Li, H., Sankoh, A. J., Clemson, C., Schacterle, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31551-4 · Cited by 795
Self-citationBrexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.
Kanes, S., Colquhoun, H., Gunduz-Bruce, H., Raines, S., Arnold, R., Schacterle, A., Doherty, J., Epperson, C. N., Deligiannidis, K. M., Riesenberg, R., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31264-3 · Cited by 479
Self-citationPostpartum psychiatric disorders
Meltzer-Brody, S., Howard, L. M., Bergink, V., Vigod, S., Jones, I., Munk-Olsen, T., Honikman, S., & Milgrom, J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.22 · Cited by 357
Self-citationPutnam, K. T., Wilcox, M., Robertson‐Blackmore, E., Sharkey, K. M., Bergink, V., Munk‐Olsen, T., Deligiannidis, K. M., Payne, J. L., Altemus, M. M., Newport, D. J., et al. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30136-0 · Cited by 308
Self-citation
Metadata
- Authors
- Johannsen, B. M. W., Larsen, J. T., Laursen, T. M., Bergink, V., Meltzer-Brody, S., & Munk-Olsen, T.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- From the National Center for Register-Based Research and the Center for Integrated Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark; the Department of Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands; and the Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill.
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2016-06-01
- Volume
- 173
- Issue
- 6
- Pages
- 635-642
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC5325688
- OpenAlex
- W2292507621
- Cited by
- 110
- References
- 32
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 15 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 8
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Lundbeckfonden (R155-2014-1724, R155-2012-11280)
- National Institute of Mental Health (R01MH104468)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- postpartum mental disorders, all-cause mortality, suicide risk, postpartum depression, childless women, mothers, mortality rate ratio, unnatural causes of death, postpartum period
- MeSH terms
- Adolescent, Adult, Mental Disorders, Cause of Death, Denmark, Female, Humans, Puerperal Disorders, Registries, Suicide, Survival Analysis, Case-Control Studies, Postpartum Period, Young Adult
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