Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

Quantifying heterogeneity in a meta‐analysis

Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763

Major depressive disorder

Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166

So depression is an inflammatory disease, but where does the inflammation come from?

Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423

Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder

Nemets, B., Stahl, Z., & Belmaker, R. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.477 · Cited by 627

A Dose-Ranging Study of the Effects of Ethyl-Eicosapentaenoate in Patients With Ongoing Depression Despite Apparently Adequate Treatment With Standard Drugs

Peet, M., & Horrobin, D. F. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.10.913 · Cited by 615

Omega-3 fatty acids in major depressive disorder

Su, K.-P., Huang, S.-Y., Chiu, C.-C., & Shen, W. W. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00032-4 · Cited by 596

Nutritional medicine as mainstream in psychiatry

Sarris, J., Logan, A. C., Akbaraly, T. N., Amminger, G. P., Balanzá-Martínez, V., Freeman, M. P., Hibbeln, J., Matsuoka, Y., Mischoulon, D., Mizoue, T., et al. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00051-0 · Cited by 592

Vitamin C in Disease Prevention and Cure: An Overview

Chambial, S., Dwivedi, S., Shukla, K. K., John, P. J., & Sharma, P. (2013) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-013-0375-3 · Cited by 585

Enhancement of recovery from psychiatric illness by methylfolate

Godfrey, P. S. A., Toone, B. K., Bottiglien, T., Laundy, M., Reynolds, E. H., Carney, M. W. P., Flynn, T. G., & Chanarin, I. (1990) · The Lancet · doi:10.1016/0140-6736(90)91942-4 · Cited by 389

Scientific Opinion on the Tolerable Upper Intake Level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA)

EFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2815 · Cited by 372

Caveat emptor: Folate in unipolar depressive illness, a systematic review and meta-analysis

Roberts, E., Carter, B., & Young, A. H. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118756060 · Cited by 35

The Relationship Between Serum Concentration of Vitamin D, Total Intracranial Volume, and Severity of Depressive Symptoms in Patients With Major Depressive Disorder

Zhu, D., Zhao, W., Zhang, B., Zhang, Y., Yang, Y., Zhang, C., Wang, Y., Zhu, J., & Yu, Y. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00322 · Cited by 33

The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk

Sublette, M. E., Daray, F. M., Ganança, L., & Shaikh, S. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02322-6 · Cited by 35

Mitochondrial Dysfunction as a Biomarker of Illness State in Bipolar Disorder: A Critical Review

Giménez‐Palomo, A., Gracia, H. A., de Juan, O., Olivier, L., Ochandiano, I., Ilzarbe, L., Valentí, M., Stoppa, A., Llach, C.-D., Pacenza, G., et al. (2024) · Brain Sciences · doi:10.3390/brainsci14121199 · Cited by 34

Soluble epoxide hydrolase: a new therapeutic target for depression

Hashimoto, K. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1226284 · Cited by 32

Dietary Acid Load and Mental Health Outcomes in Children and Adolescents: Results from the GINIplus and LISA Birth Cohort Studies

Bühlmeier, J., Harris, C. P., Koletzko, S., Lehmann, I., Bauer, C., Schikowski, T., Berg, A. V., Berdel, D., Heinrich, J., Hebebrand, J., et al. (2018) · Nutrients · doi:10.3390/nu10050582 · Cited by 32

Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior?

Weinstein‐Fudim, L., Ergaz, Z., Turgeman, G., Yanai, J., Szyf, M., & Ornoy, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215278 · Cited by 31

Treatment of Mood and Depressive Disorders With Complementary and Alternative Medicine: Efficacy Review

Cutler, J. B. R., Pane, O., Panesar, S., Updike, W. H., & Moore, T. R. (2023) · Journal of Midwifery & Women s Health · doi:10.1111/jmwh.13527 · Cited by 31

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Antoine Lefrere, A., Burtey, S., Bobot, S., Belzeaux-R, R., & Bobot, M. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115467 · Cited by 30

Clinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders

Sarris, J. J. (2017) · Australasian Psychiatry · doi:10.1177/1039856216689533 · Cited by 29

S‐Adenosyl Methionine in the Therapy of Depression and Other Psychiatric Disorders

Kuželički, N. K. (2016) · Drug Development Research · doi:10.1002/ddr.21345 · Cited by 29

EPA and DHA as markers of nutraceutical treatment response in major depressive disorder

van der Burg, K. P., Cribb, L., Firth, J., Karmacoska, D., Mischoulon, D., Byrne, G. J., Bousman, C., Stough, C. K. K., Murphy, J., Oliver, G., et al. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02090-6 · Cited by 29

Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder

Fijałkowska, A., Jędrejko, K., Sułkowska‐Ziaja, K., Ziaja, M., Kała, K., & Muszyńska, B. (2022) · Foods · doi:10.3390/foods11101489 · Cited by 31

Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials

Mashhadi, N. S., Darand, M., Rouhani, M. H., Yahay, M., Feltham, B. A., & Saraf‐Bank, S. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114083 · Cited by 31

EPA and DHA, but not ALA, have antidepressant effects with 17β-estradiol injection via regulation of a neurobiological system in ovariectomized rats

Choi, J.-E., & Park, Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.07.012 · Cited by 29

Adjunctive nutrients in first‐episode psychosis: A systematic review of efficacy, tolerability and neurobiological mechanisms

Firth, J., Rosenbaum, S., Ward, P. B., Curtis, J., Teasdale, S. B., Yung, A. R., & Sarris, J. J. (2018) · Early Intervention in Psychiatry · doi:10.1111/eip.12544 · Cited by 28

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Okla, M. K., Alamri, S. A., Alatar, A. A., Hegazy, A. K., Alghamdi, A. A., Ajarem, J. S., Faisal, M., Abdel-Salam, E. M., Ali, H. M., Salem, M. Z. M., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/1263260 · Cited by 27

Improving diet for psychiatric patients : High potential benefits and evidence for safety

Fond, G. B., Young, A. H., Godin, O., Messiaen, M., Lançon, C., Auquier, P., & Boyer, L. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.092 · Cited by 27

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Ashton, M. M., Kavanagh, B. E., Marx, W., Berk, M., Sarris, J. J., Ng, C. H., Hopwood, M., Williams, L. J., & Dean, O. M. (2020) · The Canadian Journal of Psychiatry · doi:10.1177/0706743720961734 · Cited by 27

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van der Burg, K. P., Cribb, L., Firth, J., Karmacoska, D., & Sarris, J. J. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1625222 · Cited by 28

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Giakoumatos, C. I., & Osser, D. N. (2019) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000197 · Cited by 27

Multinutrients for the Treatment of Psychiatric Symptoms in Clinical Samples: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Johnstone, J. M., Hughes, A., Goldenberg, J. Z., Romijn, A. R., & Rucklidge, J. J. (2020) · Nutrients · doi:10.3390/nu12113394 · Cited by 28

Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study

Mulugeta, A., Lumsden, A. L., & Hyppönen, E. (2020) · Nutrients · doi:10.3390/nu13010109 · Cited by 27

Trends in complementary and alternative medicine for the treatment of common mental disorders: A bibliometric analysis of two decades

Fernandes-Nascimento, M. H., & Wang, Y. (2022) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101531 · Cited by 25

Contributions of vitamin D in the management of depressive symptoms and cardiovascular risk factors: study protocol for a randomized, double-blind, placebo-controlled clinical trial

Porto, C. M., da Silva, T. D. P. S., & Sougey, É. B. (2019) · Trials · doi:10.1186/s13063-019-3699-3 · Cited by 24

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Cribb, L., Murphy, J., Froud, A., Oliver, G., Bousman, C., Ng, C. H., & Sarris, J. J. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1327685 · Cited by 24

The effect of adjunctive nutraceuticals in bipolar disorder: A systematic review of randomized placebo-controlled trials

Fusar‐Poli, L., Surace, T., Vanella, A., Meo, V., Patania, F., Furnari, R., Signorelli, M. S., & Aguglia, E. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.039 · Cited by 24

Genetic advances, biochemical and clinical features and critical approach to treatment of patients with X-linked hypophosphatemic rickets.

Baroncelli, G. I., Bertelloni, S., Sodini, F., Galli, L., Vanacore, T., Fiore, L., & Saggese, G. (2004) · PubMed · Cited by 24

Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression–A meta-analysis

Jin, X., Cheng, Z., Yu, X., Tao, Q., Huang, R., & Wang, S. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.01.080 · Cited by 26

The Role of Dietary Supplements in Depression and Anxiety – A Narrative Review

Hoffmann, K., Emons, B., Brunnhuber, S., Karaca, S., & Juckel, G. (2019) · Pharmacopsychiatry · doi:10.1055/a-0942-1875 · Cited by 26

Neuronutrients and Central Nervous System: A Systematic Review

Nogueira-de-Almeida, M. E., Zotarelli-Filho, I. J., Nogueira-de-Almeida, M. E., Souza, C. G., Kemp, V. L., & Ramos, W. S. (2022) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524923666221121123937 · Cited by 31

Adjunctive low-dose docosahexaenoic acid (DHA) for major depression: An open-label pilot trial

Smith, D. J., Sarris, J. J., Dowling, N. L., O’Connor, M., & Ng, C. H. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1283128 · Cited by 21

Popular Herbal and Natural Remedies Used in Psychiatry

Mischoulon, D. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20170041 · Cited by 23

Innovative approaches to integrating plant-based nutrition in clinical care: a path to better patient outcomes

Arslan, S., Aydın, A., Gerboğa, R., ARSLAN, H. B., Kırbıyık, K. B., Matar, A., Karabıyık, D., & Solak, E. (2024) · Clinical Science of Nutrition · doi:10.62210/clinscinutr.2024.93 · Cited by 20

Association between sucrose and fiber intake and symptoms of depression in older people

Chrząstek, Z., Guligowska, A., Pigłowska, M., Sołtysik, B. K., & Kostka, T. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1819106 · Cited by 20

Nano Matrix Soft Confectionary for Oral Supplementation of Vitamin D: Stability and Sensory Analysis

Ahmed, M. Z., Gupta, A., Warsi, M. H., Ali, A. M. A., Hasan, N., Ahmad, F. J., Zafar, A., & Jain, G. K. (2022) · Gels · doi:10.3390/gels8050250 · Cited by 20

Dissecting Causal Associations of Diet-Derived Circulating Antioxidants with Six Major Mental Disorders: A Mendelian Randomization Study

Zhao, H., Han, X., Zhang, X., Li, L., Li, Y., Wang, W., McIntyre, R. S., Teopiz, K. M., Guo, L., & Lu, C. (2023) · Antioxidants · doi:10.3390/antiox12010162 · Cited by 22

Folate supplementation as a beneficial add‐on treatment in relieving depressive symptoms: A meta‐analysis of meta‐analyses

Gao, S., Khalid, A., Amini‐Salehi, E., Radkhah, N., Jamilian, P., Badpeyma, M., & Zarezadeh, M. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4073 · Cited by 24

Novel biotherapies are needed in youth mental health

Amminger, G. P., Berger, M., Rice, S., Davey, C. G., Schäfer, M. R., & McGorry, P. D. (2017) · Australasian Psychiatry · doi:10.1177/1039856217698237 · Cited by 21

BPCO, troubles anxio-dépressifs et cognitifs : l’inflammation joue-t-elle un rôle prépondérant ?

Peiffer, G., Underner, M., Perriot, J., & Fond, G. B. (2021) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2021.03.004 · Cited by 22

Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease

Chávez-Castillo, M., Nava, M., Ortega, Á., Rojas, M., Núñez, V., Salazar, J. J., Bermúdez, V., & Rojas, J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200413144401 · Cited by 21

Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomised, placebo-controlled feasibility and exploratory trial in an under-resourced area

Sherpa, N. N., Giorgi, R. D., Ostinelli, E. G., Choudhury, A., Dolma, T., & Dorjee, S. (2024) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2024.10.004 · Cited by 27

Abnormal C-reactive protein blood levels as a specific biomarker of major depression and non-remission under antidepressants in schizophrenia

Fond, G. B., Micoulaud‐Franchi, J., Faugère, M., Boyer, L., Faget, C., Lançon, C., Richieri, R. M., & Cermolacce, M. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109800 · Cited by 20

Multiple serum biomarkers for predicting suicidal behaviours in depressive patients receiving pharmacotherapy

Kim, J., Kang, H., Kim, J.-W., Choi, W., Lee, J., Kim, S., Shin, I., Kim, M., Chun, B. J., & Stewart, R. J. (2022) · Psychological Medicine · doi:10.1017/s0033291722001180 · Cited by 18

Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information

Gedik, H., Nguyen, T. H., Peterson, R. E., Chatzinakos, C., Riley, B. P., Vladimirov, V. I., & Bacanu, S. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1191264 · Cited by 16

Naturally absorbed polyunsaturated fatty acids, lithium, and suicide-related behaviors: A case-controlled study

Kurosawa, K., Terao, T., Kanehisa, M., Shiotsuki, I., Ishii, N., Takenaka, R., Sakamoto, T., Matsukawa, T., Yokoyama, K., Ando, S., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.006 · Cited by 18

Bidirectional longitudinal associations of omega-3 polyunsaturated fatty acid plasma levels with depressive disorders

Thesing, C. S., Bot, M., Milaneschi, Y., Giltay, E. J., & Penninx, B. W. J. H. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.011 · Cited by 18

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Balanzá‐Martínez, V., Shansis, F., Tatay-Manteiga, A., & López-García, P. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200318152530 · Cited by 20

Dose increase of S-Adenosyl-Methionine and escitalopram in a randomized clinical trial for major depressive disorder

Sakurai, H., Carpenter, L. L., Tyrka, A. R., Price, L. H., Papakostas, G. I., Dording, C. M., Yeung, A., Cusin, C., Ludington, E. A., Bernard-Negron, R., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.10.040 · Cited by 17

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Tang, Y., Cui, Y., de Agostini, A. I., & Zhang, L. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.02.012 · Cited by 17

Association between all aspects of dietary diversity and risk of depressive symptoms in US adults

Li, Z., Li, P.-W., & Zhang, D. (2023) · Food & Function · doi:10.1039/d3fo00642e · Cited by 16

The effect of nutrition on older people's mental health

Harbottle, L. (2019) · British Journal of Community Nursing · doi:10.12968/bjcn.2019.24.sup7.s12 · Cited by 16

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Jahrami, H., Bragazzi, N. L., Grant, W. B., AlFarra, H. S. M., AlFara, W. S. M., Mashalla, S., & Saif, Z. (2020) · Nutrients · doi:10.3390/nu12092587 · Cited by 16

The role of soluble epoxide hydrolase and its inhibitors in depression

Borsini, A. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100325 · Cited by 16

Vitamin D and N-Acetyl Cysteine Supplementation in Treatment-Resistant Depressive Disorder Patients: A General Review

di Michele, F., Talamo, A., Niolu, C., & Siracusano, A. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200406090051 · Cited by 16

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Berk, M., & Forbes, M. (2024) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2024.02.011 · Cited by 16

Prediction of Suicidality According to Serum Folate Levels in Depressive Patients Receiving Stepwise Pharmacotherapy

Kim, J., Kim, H.-Y., Lee, H., Kim, J., Kang, H., Kim, S., Shin, I., Chun, B. J., & Stewart, R. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.747228 · Cited by 15

Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions

Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Díaz, R., López-González, L., Monserrat, J., Barrena-Blázquez, S., Álvarez-Mon, M. Á., Lahera, G., & Álvarez‐Mon, M. (2024) · Military Medical Research · doi:10.1186/s40779-024-00577-w · Cited by 21

Psychopharmacology

Deb, S. S., Bertelli, M. O., & Rossi, M. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_11 · Cited by 15

Can the Mediterranean diet decrease the risk of depression in older persons – a systematic review

Rudzińska, A. K., Perera, I., Gryglewska, B., Gąsowski, J., & Piotrowicz, K. (2022) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/140465 · Cited by 14

l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial

Shamabadi, A., Kafi, F., Bafrani, M. A., Asadigandomani, H., Basti, F. A., & Akhondzadeh, S. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.029 · Cited by 15

Serine deficiency exacerbates psoriatic skin inflammation by regulating S‐adenosyl methionine‐dependent DNA methylation and NF‐κB signalling activation in keratinocytes

Meng, Q., Liu, Y., Yao, L., Ma, Z., Guo, L., Hu, T., Luo, Y., Chen, J., Dang, E., & Li, Z. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19492 · Cited by 14

Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis

Limveeraprajak, N., Nakhawatchana, S., Visukamol, A., Siripakkaphant, C., Suttajit, S., & Srisurapanont, M. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.110985 · Cited by 14

Fatty acids and recurrence of major depressive disorder: combined analysis of two Dutch clinical cohorts

Thesing, C. S., Lok, A., Milaneschi, Y., Assies, J., Bockting, C., Figueroa, C. A., Giltay, E. J., Penninx, B. W. J. H., Ruhé, H. G., Schene, A. H., et al. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13136 · Cited by 14

Medical nutrition in mental health and disorders

Raju, M. S. V. K. (2017) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_193_17 · Cited by 14

S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors

Sales, A. J., Maciel, I. D. S., Crestani, C. C., Guimarães, F. S., & Joca, S. R. L. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105442 · Cited by 13

Association between hypovitaminosis D and cognitive inhibition impairment during major depression episode.

Belzeaux, R., Annweiler, C., Bertrand, J., Beauchet, O., Pichet, S., Jollant, F., Turecki, G., & Richard-Devantoy, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.047 · Cited by 12

A Prenatal Supplement with Methylfolate for the Treatment and Prevention of Depression in Women Trying to Conceive and during Pregnancy

Freeman, M. P., Savella, G. M., Church, T. R., Góez-Mogollón, L. M., Sosinsky, A. Z., Noe, O. B., Kaimal, A., & Cohen, L. S. (2019) · Annals of Clinical Psychiatry · doi:10.1177/104012371903100107 · Cited by 13

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Bhatt, D. L., Hull, M. A., Song, M., Hulle, C. V., Carlsson, C. M., Chapman, M. J., & Toth, P. P. (2020) · European Heart Journal Supplements · doi:10.1093/eurheartj/suaa119 · Cited by 14

Neurometabolic Abnormalities in Treatment-Resistant Depression

Mathew, S. J., & Lijffijt, M. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16101154 · Cited by 12

Processed and ultra-processed foods are associated with depression and anxiety symptoms in a cross-sectional sample of urban Lebanese adults

Ghernati, L., Tamim, H., Chokor, F. A. Z., Taktouk, M., Assi, B., Nasreddine, L., & Elbejjani, M. (2024) · Nutrition Research · doi:10.1016/j.nutres.2024.11.011 · Cited by 12

DNA Methylation as a Therapeutic and Diagnostic Target in Major Depressive Disorder

Lax, E. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.759052 · Cited by 11

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Hitzler, M., Karabatsiakis, A., & Kolassa, I. (2019) · Psychotherapeut · doi:10.1007/s00278-019-0366-9 · Cited by 15

Depressive symptoms and chronic peripheral inflammation are associated with impaired functional remission in schizophrenia independently of psychotic remission.

Fond, G. B., Faugère, M., Richieri, R. M., Cermolacce, M., Korchia, T., Micoulaud‐Franchi, J., de Verville, P. L. S., Boyer, L., & Lançon, C. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.046 · Cited by 11

Treatment of refractory obsessive–compulsive disorder with nutraceuticals (TRON): a 20-week, open label pilot study

Sarris, J. J., Byrne, G. J., Oliver, G., Cribb, L., Blair‐West, S., Castle, D. J., Dean, O. M., Camfield, D., Brakoulias, V., Bousman, C., et al. (2021) · CNS Spectrums · doi:10.1017/s1092852921000638 · Cited by 12

The Handbook of Wellness Medicine

Snellings, J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108650182 · Cited by 11

Role of Vitamin D Supplementation in Patients with Depressive Disorders and Hypovitaminosis D: A Longitudinal Study

Nebhinani, N., Sharma, P., & Suthar, N. (2017) · Journal of Mental Health and Human Behaviour · doi:10.4103/0971-8990.210712 · Cited by 11

ENTREVISTA MOTIVACIONAL

Dornellas, L. H., & Afonso, M. P. D. (2024) · Seven Editora eBooks · doi:10.56238/medestvida-002 · Cited by 11

Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysis

Cheng, Y., Huang, W., Chen, W.-Y., Huang, Y., Kuo, P., & Tu, Y. (2025) · Psychological Medicine · doi:10.1017/s0033291725000996 · Cited by 10

Evidence to Support the Use of S-Adenosylmethionine for Treatment of Post-Concussive Sequelae in the Military

Schieffler, D. A., & Matta, S. E. (2021) · Military Medicine · doi:10.1093/milmed/usab130 · Cited by 10

Improving the treatment and remission of major depression in homeless people with severe mental illness: The multicentric French Housing First (FHF) program

Fond, G. B., Tinland, A., Boucékine, M., Girard, V., Loubière, S., Boyer, L., & Auquier, P. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109877 · Cited by 10

METTL14 integrates tumor-derived SAM to drive parabrachial epigenetic rewiring in pancreatic cancer

Yang, X., Wang, X., Lu, W., Ye, Q., Li, Y., Ma, X., Ye, Y., Guo, X., Chen, G., Xin, W., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.002 · Cited by 11

Naturally absorbed lithium may prevent suicide attempts and deliberate self-harm while eicosapentaenoic acid may prevent deliberate self-harm and arachidonic acid may be a risk factor for deliberate self-harm: The updated different findings in new analyses

Izumi, T., Kanehisa, M., Terao, T., Shiotsuki, I., Shirahama, M., Satoh, M., Muronaga, M., Kohno, K., Hirakawa, H., Etoh, M., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1083739 · Cited by 9

Antidepressant Effect of Vitamin D: A Literature Review

Shi, H., Wang, B., & Xu, X. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000219 · Cited by 9

Integrative Medicine and Mood, Emotions and Mental Health

Shah, A. K., Becicka, R., Talen, M. R., Edberg, D., & Namboodiri, S. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.02.003 · Cited by 9

Psychophysiological responses to group cognitive-behavioral therapy in depressive patients

Varela, Y. M., de Almeida, R. N., Galvão, A. C. D. M., de Sousa, G. M., de Lima, A. C. L., da Silva, N. G., Leocádio-Miguel, M. A., Soares, B. L., Hallak, J. E. C., Maia‐de‐Oliveira, J. P., et al. (2021) · Current Psychology · doi:10.1007/s12144-020-01324-9 · Cited by 9

A Systematic Review of Effectiveness of Omega-3 Fatty Acid Supplementation on Symptoms, Social Functions, and Neurobiological Variables in Schizophrenia

Hsu, M., & Ouyang, W. (2021) · Biological Research For Nursing · doi:10.1177/10998004211020121 · Cited by 9

Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and dietary-related adjuncts on antidepressant treatment response: A systematic review and meta-analysis

Jeremiah, O. J., Cousins, G., Boland, F., Kirby, B. P., & Ryan, B. K. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04845 · Cited by 10

Are omega-3 fatty acids efficacious in the treatment of depression? A review

Lange, K. W., Nakamura, Y., Zhao, H., Bai, D., & Wang, H. (2021) · Journal of Food Bioactives · doi:10.31665/jfb.2021.14265 · Cited by 9

Enhancement of recovery from mental illness with l -methylfolate supplementation

Martone, G. (2017) · Perspectives In Psychiatric Care · doi:10.1111/ppc.12227 · Cited by 9

Harnessing Dietary Tryptophan: Bridging the Gap Between Neurobiology and Psychiatry in Depression Management

Chehadi, A. C., Pereira de Lima, E., Detregiachi, C. R. P., Santos de Argollo Haber, R., Catharin, V. M. C. S., Fornari Laurindo, L., Engracia Valenti, V., Machado Galhardi, C., Tanaka, M., & Maria Barbalho, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010465 · Cited by 8

Rhodiola rosea L. roots powder strongly reduces anxiety and corticosterone level induced by chronic stress in a murine model

Lelong, C., Ris, L., Sytar, O., Defrère, S., & Villers, A. (2026) · Journal of Pharmaceutical Health Care and Sciences · doi:10.1186/s40780-025-00532-4 · Cited by 8

Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials

Dyall, S. C., Malau, I. A., & Su, K. (2024) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001077 · Cited by 11

Do sex hormones or hormone therapy modify the relation of n-3 fatty acids with incident depressive symptoms in postmenopausal women? The MESA Study

Colangelo, L. A., Ouyang, P., Golden, S. H., Szklo, M., Gapstur, S. M., Vaidya, D. M., & Liu, K. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.003 · Cited by 8

Complementary Medicine and Natural Medications in Psychiatry: A Guide for the Consultation-Liaison Psychiatrist

Berman, S., Mischoulon, D., & Naidoo, U. (2020) · Psychosomatics · doi:10.1016/j.psym.2020.04.010 · Cited by 11

Efficacy and tolerability of Lavandula angustifolia in treating patients with the diagnosis of depression: a systematic review of randomized controlled trials

Shamabadi, A., & Akhondzadeh, S. (2021) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2020-0498 · Cited by 8

Advances in Alternative and Integrative Medicine in the Treatment of Depression: A Review of the Evidence

Shamabadi, A., & Akhondzadeh, S. (2021) · Archives of Iranian Medicine · doi:10.34172/aim.2021.59 · Cited by 8

Pathogenesis and management of fatigue in primary biliary cholangitis

Shamshtein, D., & Liwinski, T. (2022) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2022.2034473 · Cited by 8

Solving the crisis in psychopharmacological research: Cellular-membrane(s) pharmacology to the rescue?

Drukarch, B., Jacobs, G. E., & Wilhelmus, M. M. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110545 · Cited by 7

The Role of Folate-supplementation in Depression: A Narrative Review

Falade, J., Onaolapo, A. Y., & Onaolapo, O. J. (2020) · Current Psychopharmacologye · doi:10.2174/2211556009666201207233954 · Cited by 6

Meta‐analyses back several supplements as adjunctive treatment for depression

(2016) · The Brown University Psychopharmacology Update · doi:10.1002/pu.30159

Clinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders

Sarris, J. J. (2017) · Australasian Psychiatry · doi:10.1177/1039856216689533 · Cited by 29

Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis

Schefft, C., Kilarski, L. L., Bschor, T., & Köhler, S. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.07.004 · Cited by 127

Certain Nutritional Supplements May Enhance Effect of Antidepressant Drugs

Crane, M. (2016)

Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments

Sarris, J. J., Schoendorfer, N. C., & Kavanagh, D. J. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00180.x · Cited by 86