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Predicting Suicide Attempts and Suicide Deaths Following Outpatient Visits Using Electronic Health Records
Open accessAbstract
OBJECTIVE: The authors sought to develop and validate models using electronic health records to predict suicide attempt and suicide death following an outpatient visit. METHOD: Across seven health systems, 2,960,929 patients age 13 or older (mean age, 46 years; 62% female) made 10,275,853 specialty mental health visits and 9,685,206 primary care visits with mental health diagnoses between Jan. 1, 2009, and June 30, 2015. Health system records and state death certificate data identified suicide attempts (N=24,133) and suicide deaths (N=1,240) over 90 days following each visit. Potential predictors included 313 demographic and clinical characteristics extracted from records for up to 5 years before each visit: prior suicide attempts, mental health and substance use diagnoses, medical diagnoses, psychiatric medications dispensed, inpatient or emergency department care, and routinely administered depression questionnaires. Logistic regression models predicting suicide attempt and death were developed using penalized LASSO (least absolute shrinkage and selection operator) variable selection in a random sample of 65% of the visits and validated in the remaining 35%. RESULTS: Mental health specialty visits with risk scores in the top 5% accounted for 43% of subsequent suicide attempts and 48% of suicide deaths. Of patients scoring in the top 5%, 5.4% attempted suicide and 0.26% died by suicide within 90 days. C-statistics (equivalent to area under the curve) for prediction of suicide attempt and suicide death were 0.851 (95% CI=0.848, 0.853) and 0.861 (95% CI=0.848, 0.875), respectively. Primary care visits with scores in the top 5% accounted for 48% of subsequent suicide attempts and 43% of suicide deaths. C-statistics for prediction of suicide attempt and suicide death were 0.853 (95% CI=0.849, 0.857) and 0.833 (95% CI=0.813, 0.853), respectively. CONCLUSIONS: Prediction models incorporating both health record data and responses to self-report questionnaires substantially outperform existing suicide risk prediction tools.
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“One study of machine learning of health records for the prediction of suicide and suicide attempts examined the medical and psychiatric records of ~3 million patients with at least one mental health diagnosis across seven different health care systems 222 .”
From Suicide and suicide risk (2019) · cites this paper as [222]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In this study, an algorithm was developed that could identify 5% of the population that accounted for 43-48% of the suicides and suicide attempts, and was able to predict suicide and suicide attempts in the next 90 days with a specificity of ~70% and a sensitivity of ~80% in both specialty mental health and primary care settings 222 .”
From Suicide and suicide risk (2019) · cites this paper as [222]
Experimental — accuracy not yet measuredIn the citing paper
“multiple research groups have developed suicide risk prediction models using electronic health record data.10,11,12,13”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [12]
In the citing paper
“and 2% to 6%11,12 for predicting suicide attempts”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [12]
In the citing paper
“The corresponding PPVs were 0.1% to 0.3% for predicting suicide death12,13”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [12]
In the citing paper
“48%, from a model developed in a multistate collaboration.12”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [12]
In the citing paper
“even higher PPVs (>10%)12 could be attained by increasing specificity above 99%, although with a consequent decrease in the proportion of cases identified.”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [12]
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InfluentialScreening and Risk Algorithms for Detecting Pediatric Suicide Risk in the Emergency Department
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“We use the Mental Health Research Network risk prediction tool 16 and compare trials that identify eligible patients using patient-reported suicidal ideation (response to PHQ ninth item) and trials that use calculated suicide risk prediction scores, based on data from the patient’s electronic…”
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Prediction of Suicide Risk Using Machine Learning and Big Data
Roza, T. H., Salgado, T. A., Machado, C. D. S., Watts, D., Bebber, J. C., de Freitas, T. R. O., Rabelo‐da‐Ponte, F. D., Kapczinski, F. P., & Passos, I. C. (2023) · Springer eBooks · doi:10.1007/978-3-031-10698-9_11 · Cited by 5
Dayal, R. R., Yang, P. L., Sisson, L. N., Bajaj, M. A., Archuleta, S., Yao, S., Park, D. H., Fujii-Rios, H., & Haroz, E. E. (2025) · Journal of Medical Internet Research · doi:10.2196/57602 · Cited by 5
“Prognostic risk scores can include short-term and long-term risk factors to improve predictability [43] and better guide treatment plans over the following weeks to prevent future suicide [44].”
Evaluating the role of cost and fairness in machine learning models of suicide risk
Kitchen, C., Belouali, A., Nestadt, P. S., Wilcox, H. C., & Kharrazi, H. H. K. (2026) · Scientific Reports · doi:10.1038/s41598-026-50095-z · Cited by 5
“LASSO is frequently used in machine learning workflows to reduce collinearity of inputs and select features 4,8 .”
Palomino, K., & Correa, C. R. B. (2023) · IEEE Intelligent Systems · doi:10.1109/mis.2023.3287409 · Cited by 5
Borowski, S. C., Caine, E. D., Kumar, S. A., Karras, E., Gamble, S. A., & Vogt, D. S. (2025) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2025.01.023 · Cited by 3
Stumbo, S. P., Hooker, S. A., Rossom, R. C., Miley, K. M., Ahmedani, B. K., Lockhart, E. A., Yeh, H.-H., & Yarborough, B. J. H. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06760-0 · Cited by 4
“In contrast, the MHRN suicide risk identification models include data from approximately 20 million visits made by three million patients at seven large integrated health care systems, with broad diversity in sex, age, race, ethnicity, income, education and insurance [17].”
InfluentialSelf-citationAyilara, O. F., White, A., Dunleavy, G., Ferro, M. A., Araya, R., Schmider, J., Seward, N., & Sajobi, T. T. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120226 · Cited by 3
Yalçın, M. E., & Paltun, S. C. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1675959 · Cited by 3
McGarry, A. J., Auinger, P., Kieburtz, K. D., Bredlau, A., Hersch, S. M., & Rosas, H. D. (2022) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000001161 · Cited by 3
Predicting Poor Outcomes Among Individuals Seeking Care for Major Depressive Disorder
Liberman, J. N., Pesa, J. A., Rui, P., Teeple, A., Lakey, S. L., Wiggins, E., & Ahmedani, B. K. (2022) · Psychiatric Research and Clinical Practice · doi:10.1176/appi.prcp.20220011 · Cited by 3
“Recently, the application of advanced analytics to available digital healthcare data has highlighted the precision of models that predict suicidality using structured data (18, 19) and unstructured data, applying natural language processing techniques (20).”
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P4 suicidality screener: Literature synthesis and results from two randomized trials
Bullington, C., & Kroenke, K. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.11.004 · Cited by 3
Ripperger, M. A., Kolli, J., Wilimitis, D., Robinson, K., Reale, C., Novak, L. L., Cunningham, C. A., Kasuske, L., Grover, S. G., Ribeiro, J. D., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.42750 · Cited by 4
Yeh, P. G., & Tsai, J. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.09.044 · Cited by 3
Using transfer learning to improve prediction of suicide risk in acute care hospitals
Sacco, S. J., Chen, K., Wang, F., Rogers, S. C., & Aseltine, R. H. (2025) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocaf126 · Cited by 4
Chapter 30. Suicide Prevention Programs
Yellowlees, P., & Liu, B. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375288.lg30 · Cited by 3
Puig-Amores, I., Gordillo, I. C., & Parra, G. M.-M. (2023) · Healthcare · doi:10.3390/healthcare11101505 · Cited by 3
Estimating the Number of Self-Harm Events Not Identified by Encounter Diagnoses in Health RecordsPreprint
Simon, G. E., Shortreed, S. M., Boggs, J. M., Clarke, G. N., Rossom, R. C., Richards, J. A., & Beck, A. L. (2020) · medRxiv · doi:10.1101/2020.09.24.20200998 · Cited by 3
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“9 13 Large-scale EHR data across ages (ie, nonspecific to children) have been examined to predict suicide deaths within 90 days of ED or outpatient visits, 11,14 and often implicate sociodemographics, psychiatric diagnoses, and medication factors in predicting suicidal behavior.”
Kim, D. G., Kim, S. H., Kang, D. R., Nam, S. W., Lee, J. Y., & Lee, J. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf370 · Cited by 2
Navigating extreme class imbalance in suicide risk prediction
Kitchen, C., Belouali, A., Nestadt, P. S., Wilcox, H. C., & Kharrazi, H. H. K. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1679618 · Cited by 3
Clinical practice guideline for assessment and management of depression in India
Tripathi, A., Shukla, R., Kar, S. K., Gupta, S., Saran, P., Pattojoshi, A., & Rao, T. (2026) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry_1321_25 · Cited by 4
“[23,24]”
Blocking the Reflection: Milestones and Hurdles for Digital Twins in Mental Health
Verhees, F. G., Wiest, I. C., Kather, J. N., Kambeitz, J., & Mikoláš, P. (2026) · Pharmacopsychiatry · doi:10.1055/a-2816-2869 · Cited by 3
Kitchen, C., Nestadt, P. S., Wilcox, H. C., Richards, T., Lasser, E. C., & Kharrazi, H. H. K. (2026) · JAMIA Open · doi:10.1093/jamiaopen/ooag062 · Cited by 3
Suicide Risk Models Are Ready—Our Health Systems Are Not
Xiao, Y., Walsh, C. G., Kharrazi, H. H. K., & Mann, J. J. (2026) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2026.2397 · Cited by 2
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“in clinical samples [14, 15], and for suicide [16, 17].”
BackgroundAz öngyilkossági rizikó becslése a klinikai gyakorlatban.
Szabó, J., Vörös, V., Molnár, C., Fekete, S., Tényi, T., & Osváth, P. (2022) · Orvosi Hetilap · doi:10.1556/650.2022.32464 · Cited by 3
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A Reproducible Model Based on Clinical Text for Predicting Suicidal Behavior
Obeid, J. S., Tsalatsanis, A., Chaphalkar, C., Robinson, S., Klein, S., Cool, S., Szwast, E. A., & Bunnell, B. E. (2024) · Studies in health technology and informatics · doi:10.3233/shti231257 · Cited by 2
“Electronic health records (EHRs) have been shown to be useful in risk assessment [1].”
Risk and protective correlates of suicidality in the military health and well-being project
Schafer, K. M., Melia, R., & Joiner, T. E. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.07.141 · Cited by 2
Penfold, R. B., Yoo, H. I., Richards, J. A., Crossnohere, N. L., Johnson, E., Pabiniak, C. J., Renz, A. D., Campoamor, N. B., Simon, G. E., & Bridges, J. F. P. (2024) · JAMIA Open · doi:10.1093/jamiaopen/ooae113 · Cited by 2
Self-citationImportance of variables from different time frames for predicting self-harm using health system data
Wolock, C. J., Williamson, B. D., Shortreed, S. M., Simon, G. E., Coleman, K. J., Yeargans, R., Ahmedani, B. K., Daida, Y. G., Lynch, F. L., Rossom, R. C., et al. (2024) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2024.104750 · Cited by 2
Self-citationSandbu, M., Javo, A. C., Thapa, S. B., Rø, K. I., Preljevic, V., & Tyssen, R. (2024) · Transcultural Psychiatry · doi:10.1177/13634615241296297 · Cited by 2
“Evaluating such risk is generally found to be one of the most challenging tasks in psychiatric work (Simon et al., 2018).”
Xi, W., Banerjee, S., Alexopoulos, G. S., Olfson, M., & Pathak, J. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.01.054 · Cited by 2
Rojo-Romero, M. A., Gutiérrez-Nájera, N., Cruz-Fuentes, C. S., Romero-Pimentel, A. L., Mendoza-Morales, R., García‐Dolores, F., Morales-Marín, M. E., Castro-Martínez, X. H., González-Sáenz, E. E., Torres-Campuzano, J. A., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1429953 · Cited by 2
Mental pain and lifetime suicide attempts in early adolescence: a preliminary study
García‐Ormaza, J., Tabares, J. V., Ammendola, E., & Muela, A. (2025) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-025-00883-8 · Cited by 4
“However, evidence suggests that suicidal ideation alone is an unreliable marker for predicting suicidal behavior [20–22].”
Identifying patients at risk of suicide using data from health information exchanges
Sacco, S. J., Chen, K., Jin, J., Tang, B., Wang, F., & Aseltine, R. H. (2025) · BMC Public Health · doi:10.1186/s12889-025-22752-x · Cited by 2
“Third, our algorithm displayed low positive predictive values at 90% and 95% specificity (i.e., many patients labeled at risk were false positives), which is very similar to the performance of other suicide risk algorithms [8, 10, 13] and survey-based risk screening in adult populations [8, 35, 36].”
InfluentialGericke, F., Voorspoels, W., Peeters, E., Demyttenaere, K., Sabbe, M. B., Bantjes, J. R., & Bruffaerts, R. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116698 · Cited by 3
Are New Standards for Assessing and Managing Suicidal Patients Needed in Canada?
Links, P. S., Eynan, R., & Shah, R. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743718821341 · Cited by 2
Survival As a Patient-Centered Outcome of Mental Health Care
Schoenbaum, M. (2019) · Psychiatric Services · doi:10.1176/appi.ps.201900091 · Cited by 2
Metadata
- Authors
- Simon, G. E., Johnson, E., Lawrence, J. M., Rossom, R. C., Ahmedani, B., Lynch, F. L., Beck, A., Waitzfelder, B., Ziebell, R., Penfold, R. B., & Shortreed, S. M.
- Affiliations
- Kaiser Permanente Washington Health Research Institute (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2018-10-01
- Volume
- 175
- Issue
- 10
- Pages
- 951-960
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC6167136
- OpenAlex
- W2804266670
- Cited by
- 400
- References
- 46
- Citations by year
- 2026: 42 · 2025: 57 · 2024: 37 · 2023: 56 · 2022: 53 · 2021: 49 · 2020: 55 · 2019: 44 · 2018: 7
- FWCI
- 45.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (U19MH092201)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning in Healthcare
- Social Sciences › Psychology › Social Psychology › Mental Health via Writing
- Keywords
- suicide attempts, suicide mortality, suicide risk prediction, outpatient mental health visits, primary care visits, electronic health records, LASSO feature selection, risk score, substance use, psychiatric medication, mental health diagnoses, prediction model validation, death certificates, emergency department care, inpatient care, self-report questionnaire
- MeSH terms
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Models, Psychological, Outpatients, Surveys and Questionnaires, Risk Factors, Suicide, Attempted, Young Adult, Electronic Health Records
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