Psychedelic-assisted therapy” must not be retired
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Those with developmental trauma and personality pathology stand to benefit most from an integrated PAT.
“While some debate whether psychotherapy is necessary to add to psychedelic treatments (104) - suggesting psychedelics alone may be effective - we contend that those with developmental trauma and personality pathology stand to benefit most from an integrated PAT (107).”
From Psychoanalytically informed MDMA-assisted therapy for pathological narcissism: a novel theoretical approach (2025) · cites this paper as [107]
Cites
Must Psilocybin Always “Assist Psychotherapy”?
Goodwin, G. M., Malievskaia, E., Fonzo, G. A., & Nemeroff, C. B. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20221043 · Cited by 191 · see citing works
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Psychedelic-assisted psychotherapy: Where is the psychotherapy research
Aday, J. S., Horton, D., Fernandes-Osterhold, G., O’Donovan, A., Bradley, E. R., Rosen, R. C., & Woolley, J. D. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06620-x · Cited by 54 · see citing works
Zamaria, J. A., Fernandes-Osterhold, G., Shedler, J., & Yehuda, R. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1505894 · Cited by 29 · see citing works
O’Donnell, K. C., Okano, L., Alpert, M., Nicholas, C. R. N., Thomas, C., Poulter, B., Mithoefer, A. T., Mithoefer, M. C., & Marcela Ot’alora, G. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1427531 · Cited by 24 · see citing works
Schettino, J. R., Cheung, K., Nayak, S. M., Weiss, B., & Yaden, D. B. (2025) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2025.12.021 · Cited by 14 · see citing works
Psychological Support for Psilocybin Treatment: Reply to Letters on Our Commentary
Goodwin, G. M., Malievskaia, E., Fonzo, G. A., & Nemeroff, C. B. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230905 · Cited by 14 · see citing works
How to Make Psychedelic-Assisted Therapy Safer
Villiger, D. (2024) · Cambridge Quarterly of Healthcare Ethics · doi:10.1017/s0963180124000604 · Cited by 13 · see citing works
Knowledge gaps in psychedelic medicalisation: Clinical studies and regulatory aspects
McCulloch, D. E.-W., Liechti, M. E., Kuypers, K. P. C., Nutt, D., Lundberg, J., Stenbæk, D. S., Goodwin, G. M., Gründer, G., Butlen‐Ducuing, F., Haberkamp, M., et al. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.103938 · Cited by 12 · see citing works
Caraccio, M., Cheung, K., Mann, S. P., Bruce, L., Jacobs, E., Villiger, D., Sandbrink, J. D., Register, C., Hannikainen, I. R., Høeg, M. L., et al. (2025) · Philosophical Psychology · doi:10.1080/09515089.2025.2532761 · Cited by 8 · see citing works
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Albert, A. E., & Back, A. L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1529427 · Cited by 6 · see citing works
“Emerging research supports the safety and ef fi cacy of psychedelic-assisted therapy (PAT) when administered in a controlled clinical environment (1, 2) for several treatment-resistant psychiatric disorders including depression (3 – 5), post-traumatic stress disorder (PTSD) (6, 7), substance use disorders (8, 9), socia…”
InfluentialSingleton, S. P., Sevchik, B. L., Lahey, A., Cuijpers, P. J., Harrer, M., Jones, M. T., Nayak, S. M., Strain, E. C., Vandekar, S., Dworkin, R. H., et al. (2026) · Nature Mental Health · doi:10.1038/s44220-026-00630-8 · Cited by 6 · see citing works
Kvam, T.-M., Goksøyr, I. W., Rog, J., van de Vooren, I.-T. J., Stewart, L. H., Autran, I., Berthold‐Losleben, M., Mørch-Johnsen, L. E., Holst, R., Røssberg, J. I., et al. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.11.030 · Cited by 4 · see citing works
Setting, context and the regulatory atmospheres of psychedelic medicine
Gearin, A. K., Cohen, I. G., & Garcia‐Romeu, A. (2026) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2026.105327 · Cited by 2 · see citing works
Сучкова, И. О., Patkin, E. L., Tsikunov, S. G., & Софронов, Г. А. (2025) · Medical academic journal · doi:10.17816/maj632018 · Cited by 2 · see citing works
Improving Clinical Outcomes and Informing New Interventions
Kalin, N. H. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230929 · Cited by 1 · see citing works
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The Conceptual Framework for the Therapeutic Approach used in Phase 3 Trials of MDMA-AT for PTSDPreprint
O’Donnell, K. C., Alpert, M., Okano, L., Nicholas, C. R. N., Thomas, C., Poulter, B., Mithoefer, A. T., Mithoefer, M. C., & Marcela Ot’alora, G. (2024) · doi:10.31219/osf.io/gey78
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Schettino, J. R., Cheung, K., Nayak, S. M., & Yaden, D. B. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5225420
Therapeutic availability versus uptake in psychedelic therapy
Pennell, M., & Horstmanshof, L. (2026) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2026.03.019
The purpose of the psychosocial protocol in the psychedelic-assisted therapy: A scoping review
Ferreira, F. G. D. P., Fernandes, J. A. B., Filev, R., da Silveira, D. X., & Fidalgo, T. M. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261453850
Seynaeve, M., Schneider, L., Roullier, I., Lazenby, K., Lilley, C., Lobo, S., Ermakova, A. O., Wells, H., Cleare, A. J., & Rucker, J. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1682810
- Authors
- Deckel, G. M., Lepow, L. A., & Guss, J.
- Affiliations
- New York University (US)
- ORCID
- Lepow, Lauren A.
- Venue
- American Journal of Psychiatry
- Published
- 2024-01-01
- Volume
- 181
- Issue
- 1
- Pages
- 77-78
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W4390484527
- Cited by
- 21
- References
- 1
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- psychedelic therapy, psychedelics, treatment of mental disorders
- MeSH terms
- Hallucinogens, Humans, Psychotherapy, Retirement, Stress Disorders, Post-Traumatic, N-Methyl-3,4-methylenedioxyamphetamine
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