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Cited by 79Traumatic Brain Injury ResearchPosttraumatic Stress Disorder ResearchTraumatic Brain Injury and Neurovascular Disturbances

Predictors of Major Depression and Posttraumatic Stress Disorder Following Traumatic Brain Injury: A Systematic Review and Meta-Analysis

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Cnossen, Maryse C., Scholten, Annemieke C., Lingsma, Hester F., Synnot, Anneliese, Haagsma, Juanita, Steyerberg, Prof. Ewout W., Polinder, Suzanne·2017·The Journal of Neuropsychiatry and Clinical Neurosciences
DOI 10.1176/appi.neuropsych.16090165
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Abstract

Although major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are prevalent after traumatic brain injury (TBI), little is known about which patients are at risk for developing them. The authors systematically reviewed the literature on predictors and multivariable models for MDD and PTSD after TBI. The authors included 26 observational studies. MDD was associated with female gender, preinjury depression, postinjury unemployment, and lower brain volume, whereas PTSD was related to shorter posttraumatic amnesia, memory of the traumatic event, and early posttraumatic symptoms. Risk of bias ratings for most studies were acceptable, although studies that developed a multivariable model suffered from methodological shortcomings.

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Crossref · 10.1176/appi.neuropsych.16090165

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  • Subsequent TBI studies concurred that trauma memory impairment does not prevent PTSD but is associated with fewer re-experiencing symptoms.

    “Subsequent TBI studies specifically assessing trauma memory impairment concurred that it does not prevent PTSD but is associated with fewer re-experiencing symptoms of PTSD (Bryant et al., 2009; Cnossen et al., 2017; Gil, Caspi, Ben-Ari, Koren, & Klein, 2005).”

    From Drug-facilitated sexual assault, impaired trauma memory, and implications for mental health treatment (2022) · cites this paper as Cnossen et al., 2017

  • The present findings differ from TBI research findings of fewer re-experiencing symptoms for those absent trauma memory.

    “Although the direction of effects is similar, our findings differ from TBI research findings of fewer re-experiencing symptoms for those absent trauma memory (Bryant et al., 2009; Cnossen et al., 2017)”

    From Drug-facilitated sexual assault, impaired trauma memory, and implications for mental health treatment (2022) · cites this paper as Cnossen et al., 2017

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Authors
Cnossen, M. C., Scholten, A. C., Lingsma, H. F., Synnot, A., Haagsma, J., Steyerberg, P. E. W., & Polinder, S.
Affiliations
  • La Trobe University (AU)
  • From the Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, the Netherlands (MCC, ACS, HFL, JH, EWS, SP); the Australian & New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia (AS); and the Cochrane Consumers and Communication Review Group, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Melbourne, Australia (AS).
ORCID
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Publisher
American Psychiatric Association Publishing
Published
2017-07
Volume
29
Issue
3
Pages
206-224
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
DOI
10.1176/appi.neuropsych.16090165
OpenAlex
W2588310408
Cited by
79
References
11
Citations by year
2026: 4 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 19 · 2021: 2 · 2020: 15 · 2019: 11 · 2018: 7 · 2017: 2
FWCI
1.27
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
traumatic brain injury, major depressive disorder, post-traumatic stress disorder, risk factors, brain volume, post-traumatic amnesia, sex differences
MeSH terms
Brain Injuries, Traumatic, Depressive Disorder, Major, Major Depressive Disorder, Humans, Risk Factors, Stress Disorders, Post-Traumatic

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