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The Effect of Major Depression on Subjective and Objective Cognitive Deficits in Mild to Moderate Traumatic Brain Injury
Open accessAbstract
The effect of major depression on subjective and objective cognitive deficits 6 months following mild to moderate traumatic brain injury (TBI) was assessed in 63 subjects. Patients with subjective cognitive complaints (n=63) were more likely to be women, with higher Glasgow Coma Scale (GCS) scores and have a diagnosis of major depression. They also performed significantly more poorly on various measures of memory, attention and executive functioning. Group differences on most but not all cognitive measures disappeared in a multivariate analysis when controlling for depression. In mild to moderate TBI, subjective cognitive deficits are linked in large measure to comorbid major depression. However, other mechanisms may also account for these deficits.
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“Moreover, anxiety and depressive symptoms have a negative influence on patient rehabilitation [5] and they increase the severity and number of reported health problems such as fatigue, memory, headaches, and concentration problems [6, 7].”
From The BrainACT study: acceptance and commitment therapy for depressive and anxiety symptoms following acquired brain injury: study protocol for a randomized controlled trial. (2019) · cites this paper as [7]
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Metadata
- Authors
- Chamelian, L., & Feinstein, A.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Feinstein, Anthony
- ORCID
- Feinstein, Anthony
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2006-02
- Volume
- 18
- Issue
- 1
- Pages
- 33-38
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2137174078
- Cited by
- 174
- References
- 37
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 11 · 2018: 16 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 15 · 2012: 13
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- major depressive disorder, traumatic brain injury, mild to moderate TBI, subjective cognitive complaints, memory, attention, executive function, comorbidities, Glasgow Coma Scale, sex differences
- MeSH terms
- Adolescent, Adult, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychometrics, Risk Factors, Reproducibility of Results, Glasgow Coma Scale, Post-Concussion Syndrome
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