Cited by 52Thyroid Disorders and TreatmentsDementia and Cognitive Impairment ResearchThyroid and Parathyroid Surgery

Verbal Memory Retrieval Deficits Associated With Untreated Hypothyroidism

Miller, Karen J., Parsons, Thomas D., Whybrow, Peter C., Van Herle, Katja, Rasgon, Natalie, Van Herle, Andre, Martinez, Dorothy, Silverman, Dan H. +1 more·2007·The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

The effects of inadequate thyroid hormone availability to the brain on adult cognitive function are poorly understood. This study assessed the effects of hypothyroidism on cognitive function using a standard neuropsychological battery in 14 patients suffering from untreated hypothyroidism and complaining of subjective cognitive difficulties in comparison with 10 age-matched healthy comparison subjects. Significant differences between groups were limited to verbal memory retrieval as measured by the California Verbal Learning Test (CVLT). On short delay free recall, long delay free recall, and long delay cued recall, significant differences remained between groups despite the limited statistical power of this study. There were no significant results found between groups on attentional or nonverbal tasks. Results suggest that hypothyroid-related memory deficits are not attributable to an attentional deficit but rather to specific retrieval deficits.

Integrity signals

Registry

Crossref · 10.1176/jnp.2007.19.2.132

Cites

22 of 22 references verified0 citation errors · 0 not checkable

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Cites

Flagged first, then by citations

Research works printed but not linked: 6

  1. Sheehan DV, 1998, J Clin Psychiatry, 59, 22
  2. Wechsler D, 1987, Tex
  3. Osterrieth PA, 1944, Arch Psychol, 30, 286
  4. Army Individual Test Battery, 1944, Manual of Directions and Scoring
  5. Benton AL, 1989, Hamsher K deS: Multilingual Aphasia Examination
  6. Monzani E, 1993, Clin Invest, 71, 367

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Authors
Miller, K. J., Parsons, T. D., Whybrow, P. C., Van Herle, K., Rasgon, N., Van Herle, A., Martinez, D., Silverman, D. H., & Bauer, M.
Affiliations
University of California, Los Angeles (US)
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Published
2007-04
Volume
19
Issue
2
Pages
132-136
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
OpenAlex
W2031110024
Cited by
52
References
22
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 4
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
untreated hypothyroidism, memory impairment, cognitive function, thyroid hormones, California Verbal Learning Test, free recall, cued recall, attention, neuropsychological assessment
MeSH terms
Adult, Female, Humans, Hypothyroidism, Male, Memory Disorders, Neuropsychological Tests, Severity of Illness Index, Vocabulary

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