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Treatment of Resistant Obsessive-Compulsive Disorder With Ventral Capsular/Ventral Striatal Gamma Capsulotomy: A Pilot Prospective Study
Open accessAbstract
A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21:381-392)
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ALIC connects the frontal lobe and thalamus, as part of the cortico-striato-thalamocortical circuitry.
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From Electrical stimulation in the bed nucleus of the stria terminalis alleviates severe obsessive-compulsive disorder (2016) · cites this paper as [6]
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Metadata
- Authors
- Lopes, A. C., Greenberg, B. D., Norén, G., Canteras, M. M., Busatto, G. F., de Mathis, M. E., Taub, A., D’Alcante, C. C., Hoexter, M. Q., Gouvea, F. S., Cecconi, J. P., Gentil, A. F., Ferrão, Y. A., Fuentes, D., de Castro, C. C., Leite, C. C., Salvajoli, J. V., Duran, F. L. S., Rasmussen, S., & Miguel, E. C.
- Affiliations
- Universidade de São Paulo (BR)
- ORCID
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2009-10
- Volume
- 21
- Issue
- 4
- Pages
- 381-392
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W4240623650
- Cited by
- 139
- References
- 20
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 49 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 2 · 2015: 10 · 2014: 13 · 2013: 10 · 2012: 3
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- refractory obsessive-compulsive disorder, stereotactic radiosurgery, deep brain stimulation, treatment-resistant OCD, adverse effects, anxiety symptoms, depressive symptoms, long-term treatment response
- MeSH terms
- Adult, Basal Ganglia, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Obsessive-Compulsive Disorder, Pilot Projects, Prospective Studies, Radiosurgery, Treatment Outcome, Internal Capsule
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