Ranolazine enhances the antiarrhythmic activity of amiodarone by accelerating conversion of new-onset atrial fibrillation after cardiac surgery
Abstract
Ranolazine is a relatively novel antiischemic/antianginal compound with antiarrhythmic properties. We investigated its ability to shorten the time to conversion of postoperative atrial fibrillation (POAF) when added to amiodarone after coronary artery bypass graft (CABG) surgery. In this prospective, randomized, allocation-concealed, single-blind, single-site clinical trial, we enrolled consecutive eligible patients who developed POAF after elective on-pump CABG surgery. Participants were randomized to receive either ranolazine 375 mg twice daily orally plus intravenous amiodarone (active group) or intravenous amiodarone alone (control group). We enrolled 41 patients; 20 in the active and 21 in the control group. There were no significant differences between the groups in terms of age, procedural duration, extracorporeal circulation time, and aortic cross-clamp time. Mean time of conversion was significantly shorter in the active group (19.9 ± 3.2 vs 37.2 ± 3.9 hours, P < .001), suggesting that compared to amiodarone alone, the ranolazine-amiodarone combination had a superior antiarrhythmic effect against POAF.
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Small, open-label studies suggest that ranolazine might enhance the antiarrhythmic effect of amiodarone for cardioversion.
“Small, open-label studies suggest that ranolazine might enhance the antiarrhythmic effect of amiodarone for cardioversion, 681-683”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [682]
Cites
Mechanisms, Prevention, and Treatment of Atrial Fibrillation After Cardiac Surgery
Echahidi, N., Pîbarot, P., O’Hara, G. E., & Mathieu, P. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.043 · Cited by 678 · see citing works
Scirica, B. M., Morrow, D. A., Hod, H., Murphy, S. A., Belardinelli, L., Hedgepeth, C. M., Molhoek, P. G., Verheugt, F. W. A., Gersh, B. J., McCabe, C. H., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.724880 · Cited by 444 · see citing works
Atrium-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation
Burashnikov, A., Diego, J. M. D., Zygmunt, A. C., Belardinelli, L., & Antzelevitch, C. N. (2007) · Circulation · doi:10.1161/circulationaha.107.704890 · Cited by 399 · see citing works
Efficacy of Ranolazine in Patients With Chronic Angina
Wilson, S. R., Scirica, B. M., Braunwald, E., Murphy, S. A., Karwatowska-Prokopczuk, E., Buros, J. L., Chaitman, B. R., & Morrow, D. A. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.01.037 · Cited by 198 · see citing works
Atrial fibrillation after cardiac operation: risks, mechanisms, and treatment
Hogue, C. W. J., & Hyder, M. (2000) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)01267-9 · Cited by 194 · see citing works
Mitchell, L. B. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.11.005 · Cited by 165 · see citing works
Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations
Sicouri, S., Glass, A. M., Belardinelli, L., & Antzelevitch, C. N. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.03.018 · Cited by 120 · see citing works
Postrepolarization Refractoriness Versus Conduction Slowing Caused by Class I Antiarrhythmic Drugs
Kirchhof, P. F., Fabritz, L., & Franz, M. R. (1998) · Circulation · doi:10.1161/01.cir.97.25.2567 · Cited by 88 · see citing works
Fragakis, N., Koskinas, K. C., Katritsis, D. G., Pagourelias, E. D., Zografos, T., & Geleris, P. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.044 · Cited by 82 · see citing works
Ranolazine: A Novel Metabolic Modulator for the Treatment of Angina
McCormack, J. G., Stanley, W. C., & Wolff, A. A. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00301-7 · Cited by 82 · see citing works
Koller, B. S., Karasik, P., Solomon, A. J., & Franz, M. R. (1995) · Circulation · doi:10.1161/01.cir.91.9.2378 · Cited by 81 · see citing works
Dhalla, A. K., Wang, W., Dow, J., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00173.2009 · Cited by 75 · see citing works
Davidenko, J. M., & Antzelevitch, C. (1986) · Circulation Research · doi:10.1161/01.res.58.2.257 · Cited by 61 · see citing works
Postoperative Atrial Fibrillation - What Do We Really Know?
Banach, M., Kourliouros, A., Reinhart, K. M., Benussi, S., Mikhailidis, D. P., Jahangiri, M., Baker, W. L., Galanti, A., Rysz, J., Camm, A. J., et al. (2010) · Current Vascular Pharmacology · doi:10.2174/157016110791330807 · Cited by 59 · see citing works
Banach, M., Mariscalco, G., Uğurlucan, M., Mikhailidis, D. P., Barylski, M., & Rysz, J. (2008) · EP Europace · doi:10.1093/europace/eun273 · Cited by 56 · see citing works
Arnold, S. V., Morrow, D. A., Wang, K., Lei, Y., Mahoney, E. M., Scirica, B. M., D, E. B. M., & Cohen, D. J. (2008) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.108.798009 · Cited by 49 · see citing works
Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model
Nieminen, T. V. M., Nanbu, D. Y., Datti, I. P., Vaz, G. R., Tavares, C. A. M., Pegler, J. R. M., Nearing, B. D., Belardinelli, L., & Verrier, R. L. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.11.029 · Cited by 45 · see citing works
Ouzounian, M., Buth, K. J., Valeeva, L., Morton, C. C., Hassan, A., & Ali, I. S. (2012) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2011.10.058 · Cited by 40 · see citing works
Bandeali, S. J., Kayani, W. T., Lee, V., Pan, W., Elayda, M. A. A., Nambi, V., Jneid, H. M., Alam, M., Wilson, J. M., Birnbaum, Y., et al. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.05.021 · Cited by 39 · see citing works
Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits
Frommeyer, G., Kaiser, D., Uphaus, T., Kaese, S., Osada, N., Rajamani, S., Belardinelli, L., BREITHARDT, G. E., Eckardt, L., & Milberg, P. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.08.029 · Cited by 38 · see citing works
Carvas, M., Nascimento, B., Acar, M., et al. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181d26416 · Cited by 33 · see citing works
Predictors of Atrial Fibrillation following Coronary Artery Bypass Grafting
Sabzi, F., Zokaei, A., & Moloudi, A. R. (2011) · Clinical Medicine Insights Cardiology · doi:10.4137/cmc.s7170 · Cited by 29 · see citing works
Pharmacological conversion of recent-onset atrial fibrillation: A systematic review
Heldal, M., & Atar, D. (2012) · Scandinavian Cardiovascular Journal · doi:10.3109/14017431.2012.740572 · Cited by 27 · see citing works
Radaelli, G., Bodanese, L. C., Guaragna, J. C. V. D. C., et al. (2011) · Brazilian Journal of Cardiovascular Surgery · doi:10.5935/1678-9741.20110011 · Cited by 24 · see citing works
Aidonidis, I., Doulas, K., Hatziefthimiou, A. A., et al. (2012) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248412453874 · Cited by 20 · see citing works
Self-citationRisk Factors For Recurrent Stroke After Coronary Artery Bypass Grafting
Cao, L., Li, Q., Bi, Q., & Yu, Q. (2011) · Journal of Cardiothoracic Surgery · doi:10.1186/1749-8090-6-157 · Cited by 18 · see citing works
A Focus on Antiarrhythmic Properties of Ranolazine
Vizzardi, E., D’Aloia, A., Quinzani, F., et al. (2012) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248412442000 · Cited by 17 · see citing works
Costs and Clinical Outcomes Associated with Use of Ranolazine for Treatment of Angina
Phelps, C. E., Buysman, E. K., & Rey, G. G. (2012) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.04.025 · Cited by 16 · see citing works
Rostagno, C. (2012) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152512803530306 · Cited by 11 · see citing works
Effects of Ranolazine on Cardiovascular System
Bonadei, I., Vizzardi, E., Quinzani, F., et al. (2011) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489011797377103 · Cited by 6 · see citing works
Perspective: does ranolazine have potential for the treatment of atrial fibrillation?
Hancox, J. C., & Doggrell, S. A. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.535517 · Cited by 6 · see citing works
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Ranolazine enhances the efficacy of amiodarone for conversion of recent-onset atrial fibrillation
Koskinas, K. C., Fragakis, N., Katritsis, D., Skeberis, V., & Vassilikos, V. (2014) · Europace · doi:10.1093/europace/eut407 · Cited by 72 · see citing works
- Authors
- Simopoulos, V., Tagarakis, G. I., Daskalopoulou, S. S., Daskalopoulos, M. E., Lenos, A., Chryssagis, K., Skoularingis, I., Molyvdas, P.-A., Tsilimingas, N. B., & Aidonidis, I.
- Affiliations
- University of Thessaly (GR)
- McGill University (CA)
- Vascular Surgery Unit, Thriassio General Hospital, Athens, Greece
- Rhön-Klinikum (DE)
- Department of Cardiology, University of Thessaly, Larissa, Greece
- Corresponding author
- Aidonidis, Isaac
- Venue
- Angiology
- Publisher
- SAGE Publications
- Published
- 2013-02-20
- Volume
- 65
- Issue
- 4
- Pages
- 294-297
- ISSN
- 0003-3197 (ISSN-L)
- 1940-1574
- OpenAlex
- W2091800943
- Cited by
- 43
- References
- 31
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 14 · 2015: 3 · 2014: 4 · 2013: 1
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angiology (publishedVersion)
- PubMed (publishedVersion)
- University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- ranolazine, amiodarone, postoperative atrial fibrillation, coronary artery bypass grafting, conversion to sinus rhythm, antiarrhythmic drugs, cardiac surgery complications
- MeSH terms
- Ranolazine, Acetanilides, Administration, Oral, Aged, Amiodarone, Anti-Arrhythmia Agents, Coronary Artery Bypass, Atrial Fibrillation, Cardiopulmonary Bypass, Drug Administration Schedule, Drug Synergism, Drug Therapy, Combination, Female, Greece, Humans, Infusions, Intravenous, Male, Middle Aged, Piperazines, Prospective Studies, Time Factors, Single-Blind Method, Treatment Outcome, Elective Surgical Procedures
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