Best practice in statistics: The use of log transformation
Open accessAbstract
The log transformation is often used to reduce skewness of a measurement variable. If, after transformation, the distribution is symmetric, then the Welch t-test might be used to compare groups. If, also, the distribution becomes close to normal, then a reference interval might be determined.
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The sampling weights were adjusted based on the disease count in each type and moderated by natural logarithm transformation.
“The sampling weights were adjusted based on the disease count in each type and moderated by natural logarithm transformation43,44.”
From Enhancing diagnostic capability with multi-agents conversational large language models (2025) · cites this paper as [44]
The Introduction’s ‘Natural logarithm or common logarithm’ section says natural logarithms can be used for log transformation. The paper illustrates transformation with urine albumin measurements; it does not describe adjusting sampling weights by disease counts or applying a logarithm to those weights. (LLM, conf=0.85)
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Best practice in statistics: Use the Welch t -test when testing the difference between two groups
West, R. M. (2021) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563221992088 · Cited by 202 · see citing works
Self-citationNational Health and Nutrition Examination Survey, The
(2020) · Springer eBooks · doi:10.1007/978-3-030-39903-0_301242 · Cited by 105 · see citing works
Use of routine clinical laboratory data to define reference intervals
Shine, B. S. F. (2008) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.008028 · Cited by 36 · see citing works
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Enhancing diagnostic capability with multi-agents conversational large language models
Chen, X., Yi, H., You, M., Liu, W., Wang, L., Li, H., Zhang, X., Guo, Y., Fan, L., Chen, G., et al. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01550-0 · Cited by 117 · see citing works
- Authors
- West, R. M.
- Affiliations
- University of Leeds (GB)
- Corresponding author
- West, Robert M
- ORCID
- West, Robert M
- Venue
- Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
- Publisher
- SAGE Publications
- Published
- 2021-10-19
- Volume
- 59
- Issue
- 3
- Pages
- 162-165
- ISSN
- 0004-5632 (ISSN-L)
- 1758-1001
- PMC
- PMC9036143
- OpenAlex
- W3206948482
- Cited by
- 335
- References
- 3
- Citations by year
- 2026: 115 · 2025: 113 · 2024: 64 · 2023: 38 · 2022: 5
- FWCI
- 16.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of Clinical Biochemistry International Journal of Laboratory Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Physical Sciences › Mathematics › Statistics and Probability › Probabilistic Statistics in Medicine
- Keywords
- logarithmic transformation, measurement variables, reference values, normality
- MeSH terms
- Humans, Reference Values
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