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Cited by 11Schizophrenia research and treatmentDementia and Cognitive Impairment ResearchHistorical and Modern Theater Studies

Comparing neurocognition in severe chronic schizophrenia and frontotemporal dementia

Chan, Hui-Minn, Stolwyk, Rene, Kelso, Wendy, Neath, Joanna, Walterfang, Mark, Mocellin, Ramon, Pavlis, Alexia, Velakoulis, Dennis·2014·Australian & New Zealand Journal of Psychiatry
DOI 10.1177/0004867414529477
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Abstract

Objective Previous research has suggested cognitive similarities between schizophrenia and frontotemporal dementia. In the current study, we compared neurocognition in a group of hospitalised patients with chronic schizophrenia, who may have a more severe form of schizophrenia resembling Emil Kraepelin's dementia praecox, with patients with frontotemporal dementia. We hypothesised minimal group differences in cognitive performance, and a large overlap in between-group score distributions in each cognitive domain. Methods Retrospective neuropsychological data for 26 patients with severe chronic schizophrenia and 34 patients with frontotemporal dementia (behavioural variant) was collated. Neuropsychological measures were categorised into 16 cognitive domains. Raw scores were converted into standardised z-scores for each measure, which were then averaged across measures within each domain. In addition to difference analysis, equivalence testing was utilised, whereby overlap percentages were computed to reflect the amount of score distribution overlap in each domain between groups. Results A statistically significant difference was observed only in the executive function sub-domain of Switching. Small-to-moderate and moderate effect sizes were noted in four other domains. Equivalence testing showed more than 85% of overlap in score distribution in most domains. Conclusions Our findings suggest that some patients with severe chronic schizophrenia have cognitive deficits similar in…

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  • Executive functions are significantly affected in PPD.

    “While executive functions are also significantly affected in PPD (Ziauddeen et al. , 2011; Chan et al. , 2014; Vijverberg et al. , 2017 c ), persistent and progressive executive dysfunction over time despite improvement in psychiatric symptoms should raise suspicion for bvFTD.”

    From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Chan et al. , 2014

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Authors
Chan, H.-M., Stolwyk, R., Kelso, W., Neath, J., Walterfang, M., Mocellin, R., Pavlis, A., & Velakoulis, D.
Affiliations
  • The Royal Melbourne Hospital (AU)
  • School of Psychological Sciences, Monash University, Clayton, Australia
ORCID
Venue
Australian & New Zealand Journal of Psychiatry
Publisher
SAGE Publications
Published
2014-04-07
Volume
48
Issue
9
Pages
828-837
ISSN
  • 0004-8674 (ISSN-L)
  • 1440-1614
DOI
10.1177/0004867414529477
OpenAlex
W2329307084
Cited by
11
References
46
Citations by year
2025: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2015: 1 · 2014: 1
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Australian & New Zealand Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Victoria University Research Repository (Victoria University) (submittedVersion)
Funders
Monash University
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
frontotemporal dementia, dementia praecox, neurocognitive function, cognitive impairment, executive function, switching, behavioral variant frontotemporal dementia, differential diagnosis
MeSH terms
Adult, Aged, Cognition, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Schizophrenic Psychology, Young Adult, Executive Function, Frontotemporal Dementia

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