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Rickets Secondary to Phosphate Depletion: A Sequela of Antacid Use in Infancy
Abstract
Two infants presented with growth failure and were found to have generalized osteomalacia (rickets) due to phosphate depletion from prolonged administration of an aluminum-containing antacid given for the symptoms of colic. One of the infants developed bilateral proptosis due to craniosynostosis related to the underlying metabolic bone disease. The chronic use of aluminum-containing antacids in infants has potential risk for the growing skeleton and is not innocuous. Therefore, antacid therapy should be used in low doses and very cautiously, with routine monitoring of serum calcium and phosphorus in children taking medications which reduce gastrointestinal phosphate absorption.
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“There are case reports of osteomalacia and rickets in infants and adults using Al-containing antacids for the treatment of gastrointestinal illnesses (Chines and Pacifici, 1990; Pivnick et al., 1995; Woodson, 1998).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Pivnick et al., 1995
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Cited by
Sorted by citations
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“There are case reports of osteomalacia and rickets in infants and adults using Al-containing antacids for the treatment of gastrointestinal illnesses (Chines and Pacifici, 1990; Pivnick et al., 1995; Woodson, 1998).”
BackgroundAluminum toxicokinetics regarding infant diet and vaccinations.
Keith, L. S., Jones, D. E., & Chou, C.-H. S. J. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00165-2 · Cited by 83
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Metadata
- Authors
- Pivnick, E. K., Kerr, N. C., Kaufman, R. A., Jones, D. P., & Chesney, R. W.
- Affiliations
- University of Tennessee Health Science Center (US)
- University of Massachusetts Chan Medical School (US)
- Le Bonheur Children's Hospital (US)
- University of Tennessee at Knoxville (US)
- Venue
- Clinical Pediatrics
- Publisher
- SAGE Publications
- Published
- 1995-02
- Volume
- 34
- Issue
- 2
- Pages
- 73-78
- ISSN
- 0009-9228 (ISSN-L)
- 1938-2707
- OpenAlex
- W2105637516
- Cited by
- 65
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- rickets, phosphate limitation, osteomalacia, infants, colic, growth failure, craniosynostosis, proptosis, metabolic bone disease
- MeSH terms
- Aluminum Hydroxide, Antacids, Colic, Drug Combinations, Female, Humans, Infant, Intestinal Absorption, Magnesium Hydroxide, Osteomalacia, Phosphates, Radiography, Rickets, Simethicone
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Rickets Secondary to Phosphate Depletion: A Sequela of Antacid Use in Infancy. https://app.cochat.ai/papers/10.1177/000992289503400202
- The paper
- Pivnick, E. K., Kerr, N. C., Kaufman, R. A., Jones, D. P., & Chesney, R. W. (1995). Rickets Secondary to Phosphate Depletion: A Sequela of Antacid Use in Infancy. Clinical Pediatrics. https://doi.org/10.1177/000992289503400202
