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Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine

Open access
Huang, G.T.-J., Gronthos, S., Shi, S.·2009·Journal of Dental Research

Abstract

To date, 5 different human dental stem/progenitor cells have been isolated and characterized: dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAP), and dental follicle progenitor cells (DFPCs). These postnatal populations have mesenchymal-stem-cell-like (MSC) qualities, including the capacity for self-renewal and multilineage differentiation potential. MSCs derived from bone marrow (BMMSCs) are capable of giving rise to various lineages of cells, such as osteogenic, chondrogenic, adipogenic, myogenic, and neurogenic cells. The dental-tissue-derived stem cells are isolated from specialized tissue with potent capacities to differentiate into odontogenic cells. However, they also have the ability to give rise to other cell lineages similar to, but different in potency from, that of BMMSCs. This article will review the isolation and characterization of the properties of different dental MSC-like populations in comparison with those of other MSCs, such as BMMSCs. Important issues in stem cell biology, such as stem cell niche, homing, and immunoregulation, will also be discussed.

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Metadata

Authors
Huang, G. T.-J., Gronthos, S., & Shi, S.
Venue
Journal of Dental Research
Published
2009-09
Volume
88
Issue
9
Pages
792-806
ISSN
  • 0022-0345 (ISSN-L)
  • 1544-0591
OpenAlex
W2145040826
Cited by
1,871
References
4
FWCI
34.43
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine. https://app.cochat.ai/papers/10.1177/0022034509340867
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Huang, G. T.-J., Gronthos, S., & Shi, S. (2009). Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine. Journal of Dental Research. https://doi.org/10.1177/0022034509340867

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.