Exosomes for drug delivery—A novel application for the mesenchymal stem cell
Abstract
Exosomes are the most extensively characterized class of secreted membrane vesicles that carry proteins and RNAs for intercellular communication. They are increasingly seen as possible alternatives to liposomes as drug delivery vehicles. Like liposomes, they could deliver their cargo across the plasma membrane and provide a barrier against premature transformation and elimination. In addition, these naturally-occurring secreted membrane vesicles are less toxic and better tolerated in the body as evidenced by their ubiquitous presence in biological fluids, and have an intrinsic homing ability. They are also amenable to in vivo and in vitro loading of therapeutic agents, and membrane modifications to enhance tissue-specific homing. Here we propose human mesenchymal stem cells as the ideal cell source of exosomes for drug delivery. Mesenchymal stem cell transplantation for various disease indications has been extensively tested and shown to be safe in numerous clinical trials. These cells are also prolific producers of immunologically inert exosomes. Immortalization of these cells does not compromise the quantity or quality of exosome production, thus enabling infinite and reproducible exosome production from a single cell clone.
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Exosomes can be detected in almost any body fluids, indicating their transport cargo could go through membrane and be protected from degradations.
“Exosomes could be detected in almost any body fluids (blood, cerebrospinal fluid, saliva, etc.), indicating their transport cargo could go through membrane and be protected from degradations [30].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [30]
Cites
1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,289 · see citing works
RetractedMultilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282 · see citing works
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511 · see citing works
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works
B lymphocytes secrete antigen-presenting vesicles.
Raposo, G., Nijman, H. W., Stoorvogel, W., Liejendekker, R., Harding, C. V., Melief, C. J., & Geuze, H. J. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.3.1161 · Cited by 3,546 · see citing works
Kern, S., Eichler, H., Stoeve, J., Klüter, H., & Bieback, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0342 · Cited by 3,370 · see citing works
Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., Grisanti, S., & Gianni, A. M. (2002) · Blood · doi:10.1182/blood.v99.10.3838 · Cited by 3,226 · see citing works
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992 · see citing works
Blanc, K. L., Frassoni, F., Ball, L. M., Locatelli, F., Roelofs, H., Lewis, I., Lanino, E., Sundberg, B., Bernardo, M. E., Remberger, M., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60690-x · Cited by 2,692 · see citing works
In VitroChondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells
Johnstone, B., Hering, T. M., Caplan, A. I., Goldberg, V. M., & Yoo, J. U. (1998) · Experimental Cell Research · doi:10.1006/excr.1997.3858 · Cited by 2,381 · see citing works
Bartholomew, A. M., Sturgeon, C., Siatskas, M., Ferrer, K., McIntosh, K. R., Patil, S., Hardy, W., Devine, S. M., Ucker, D. S., Deans, R., et al. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00769-x · Cited by 2,296 · see citing works
Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215 · see citing works
Identification and proteomic profiling of exosomes in human urine
Pisitkun, T., Shen, R., & Knepper, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403453101 · Cited by 2,162 · see citing works
Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042 · see citing works
Phinney, D. G., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0637 · Cited by 1,910 · see citing works
Huang, G. T. ‐., Gronthos, S., & Shi, S. (2009) · Journal of Dental Research · doi:10.1177/0022034509340867 · Cited by 1,876 · see citing works
Human mesenchymal stem cells modulate B-cell functions
Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., Risso, M., Gualandi, F., Mancardi, G. L., Pistoia, V., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2657 · Cited by 1,767 · see citing works
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
Wolfers, J., Lozier, A., Raposo, G., Régnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,643 · see citing works
Ratajczak, J., Miękus, K., Kucia, M., Zhang, J., Reca, R., Dvořák, P., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404132 · Cited by 1,630 · see citing works
Chen, L., Tredget, E. E., Wu, P. Y. G., & Wu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001886 · Cited by 1,610 · see citing works
Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579 · see citing works
Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro
Sanchez‐Ramos, J., Song, S., Cardozo‐Pelaez, F., Hazzi, C., Stedeford, T. J., Willing, A. E., Freeman, T. B., Saporta, S., Janssen, W. E., Patel, N. A., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7389 · Cited by 1,562 · see citing works
Tse, W. T., Pendleton, J. D., Beyer, W., Egalka, M. C., & Guinan, E. C. (2003) · Transplantation · doi:10.1097/01.tp.0000045055.63901.a9 · Cited by 1,501 · see citing works
Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488 · see citing works
Mechanisms involved in the therapeutic properties of mesenchymal stem cells
da Silva Meirelles, L., Fontes, A. M., Covas, D. T., & Caplan, A. I. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.002 · Cited by 1,436 · see citing works
Blanc, K. L., Tammik, L., Sundberg, B., Haynesworth, S. E., & Ringdén, O. T. H. (2003) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2003.01176.x · Cited by 1,367 · see citing works
Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356 · see citing works
Hare, J. M., Traverse, J. H., Henry, T. D., Dib, N., Strumpf, R. K., Schulman, S. P., Gerstenblith, G., DeMaria, A. N., Denktas, A. E., Gammon, R. S., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.06.055 · Cited by 1,350 · see citing works
Exosomal-like vesicles are present in human blood plasma
Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348 · see citing works
Kinnaird, T. D., Stabile, E., Burnett, M. S., Shou, M., Lee, C. W., Barr, S., Fuchs, S., & Epstein, S. E. (2004) · Circulation · doi:10.1161/01.cir.0000124062.31102.57 · Cited by 1,304 · see citing works
Characterization of cells with osteogenic potential from human marrow
Haynesworth, S. E., GOSHIMA, J., Goldberg, V., & Caplan, A. I. (1992) · Bone · doi:10.1016/8756-3282(92)90364-3 · Cited by 1,291 · see citing works
Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer
Rabinowits, G., Gerçel-Taylor, Ç., Day, J. M., Taylor, D. D., & Kloecker, G. H. (2009) · Clinical Lung Cancer · doi:10.3816/clc.2009.n.006 · Cited by 1,261 · see citing works
Exosomes with Immune Modulatory Features Are Present in Human Breast Milk
Admyre, C., Johansson, S. M., Qazi, K. R., Filén, J., Lahesmaa, R., Norman, M., Neve, E. P. A., Scheynius, A., & Gabrielsson, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1969 · Cited by 1,222 · see citing works
Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
Denzer, K., Kleijmeer, M. J., Heijnen, H. F. G., Stoorvogel, W., & Geuze, H. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.19.3365 · Cited by 1,067 · see citing works
Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis
Hood, J. L., San, R. S., & Wickline, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4455 · Cited by 1,037 · see citing works
Autologous Transplantation of Bone Marrow Cells Improves Damaged Heart Function
Tomita, S., Li, R., Weisel, R. D., Mickle, D. A. G., Kim, E. J., Sakai, T., & Jia, Z.-Q. (1999) · Circulation · doi:10.1161/01.cir.100.suppl_2.ii-247 · Cited by 1,009 · see citing works
Cells release prions in association with exosomes
Février, B., Vilette, D., Archer, F., Loew, D., Faigle, W., Vidal, M., Laude, H., & Raposo, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308413101 · Cited by 998 · see citing works
Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes
Théry, C., Duban, L., Segura, É., Véron, P., Lantz, O. J., & Amigorena, S. (2002) · Nature Immunology · doi:10.1038/ni854 · Cited by 961 · see citing works
Lee, R. H., Kim, B., Choi, I., Kim, H., Choi, H. S., Suh, K. T., Bae, Y. C., & Jung, J. S. (2004) · Cellular Physiology and Biochemistry · doi:10.1159/000080341 · Cited by 933 · see citing works
Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes
Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 886 · see citing works
ExoCarta: A compendium of exosomal proteins and RNA
Mathivanan, S., & Simpson, R. J. (2009) · PROTEOMICS · doi:10.1002/pmic.200900351 · Cited by 873 · see citing works
Rapid Secretion of Interleukin-1β by Microvesicle Shedding
Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862 · see citing works
The Chondrogenic Potential of Human Bone-Marrow-Derived Mesenchymal Progenitor Cells*
Yoo, J. U., BARTHEL, T. S., Nishimura, K., Solchaga, L. A., Caplan, A. I., Goldberg, V. M., & Johnstone, B. (1998) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199812000-00004 · Cited by 857 · see citing works
Sokolova, V., Ludwig, A., Hornung, S., Rotan, O., Horn, P. A., Epple, M., & Giebel, B. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.05.013 · Cited by 853 · see citing works
Proteomic profiling of exosomes: Current perspectives
Simpson, R. J., Jensen, S. S., & Lim, J. W. E. (2008) · PROTEOMICS · doi:10.1002/pmic.200800109 · Cited by 850 · see citing works
Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery
Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 816 · see citing works
Circulating microparticles: pathophysiology and clinical implications
Piccin, A., Murphy, W. G., & Smith, O. P. (2006) · Blood Reviews · doi:10.1016/j.blre.2006.09.001 · Cited by 799 · see citing works
Bone regeneration by implantation of purified, culture‐expanded human mesenchymal stem cells
Bruder, S. P., Kurth, A. A., Shea, M., Hayes, W. C., Jaiswal, N., & Kadiyala, S. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160202 · Cited by 761 · see citing works
Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes
Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 716 · see citing works
Production and characterization of clinical grade exosomes derived from dendritic cells
Lamparski, H., Mehta-Damani, A., Yao, J.-Y., Patel, S., Hsu, D., Ruegg, C. L., & Pecq, J. L. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00330-7 · Cited by 701 · see citing works
Lipid raft-associated protein sorting in exosomes
Gassart, A. D., Géminard, C., Février, B., Raposo, G., & Vidal, M. (2003) · Blood · doi:10.1182/blood-2003-03-0871 · Cited by 675 · see citing works
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
Chen, T. S., Lai, R. C., Lee, M. M., Choo, A. B. H., Lee, C. N., & Lim, S. K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp857 · Cited by 660 · see citing works
Tsai, M. (2004) · Human Reproduction · doi:10.1093/humrep/deh279 · Cited by 659 · see citing works
Human Placenta‐Derived Cells Have Mesenchymal Stem/Progenitor Cell Potential
Fukuchi, Y., Nakajima, H., Sugiyama, D., Hirose, I., Kitamura, T., & Tsuji, K. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-649 · Cited by 646 · see citing works
Togel, F. E., Weiss, K., Yang, Y., Hu, Z., Zhang, P., & Westenfelder, C. S. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00339.2006 · Cited by 642 · see citing works
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium.
Timmers, L., Lim, S. K., Arslan, F., Armstrong, J., Hoefer, I., Doevendans, P., Piek, J., Oakley, R. E., Choo, A., Lee, C. N., et al. (2008) · Stem Cell Research · doi:10.1016/j.scr.2008.02.002 · Cited by 622 · see citing works
Duijvestein, M., Vos, A. C. W., Roelofs, H., Wildenberg, M. E., Wendrich, B. B., Verspaget, H. W., Kooy-Winkelaar, E. M. C., Koning, F., Zwaginga, J. J., Fidder, H. H., et al. (2010) · Gut · doi:10.1136/gut.2010.215152 · Cited by 622 · see citing works
Giordano, A., Galderisi, U., & Marino, I. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20959 · Cited by 611 · see citing works
Collino, F., Deregibus, M. C., Bruno, S., Sterpone, L., Aghemo, G., Viltono, L., Tetta, C., & Camussi, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011803 · Cited by 608 · see citing works
Mathivanan, S., Lim, J. W. E., Tauro, B. J., Ji, H. L., Moritz, R. L., & Simpson, R. J. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900152-mcp200 · Cited by 593 · see citing works
von Bahr, L., Batsis, I., Moll, G., Hägg, M., Szakos, A., Sundberg, B., Uzunel, M., Ringdén, O. T. H., & Blanc, K. L. (2012) · Stem Cells · doi:10.1002/stem.1118 · Cited by 578 · see citing works
Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes
Banas, A., Teratani, T., Yamamoto, Y., Tokuhara, M., Takeshita, F., Quinn, G., Okochi, H., & Ochiya, T. (2007) · Hepatology · doi:10.1002/hep.21704 · Cited by 555 · see citing works
Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., Newman, G. R., & Jasani, B. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00321-5 · Cited by 555 · see citing works
Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
Lai, R. C., Chen, T. S., & Lim, S. K. (2011) · Regenerative Medicine · doi:10.2217/rme.11.35 · Cited by 553 · cited 2× · see citing works
“on exosome function, the reader may refer to this review (Lai et al., 2011).”
BackgroundYoung, W., Steele, T. A., Bray, R. A., Hudson, J. A., Floyd, J. A., Hawkins, K. C., Thomas, K. S. C., Austin, T., Edwards, C., Cuzzourt, J., et al. (2001) · The Anatomical Record · doi:10.1002/ar.1128 · Cited by 545 · see citing works
Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production
Clayton, A., Al-Taei, S., Webber, J., Mason, M. D., & Tabi, Z. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003884 · Cited by 540 · see citing works
Allogeneic Mesenchymal Stem Cell Transplantation in Postinfarcted Rat Myocardium
Dai, W., Hale, S. L., Martin, B. J., Kuang, J.-Q., Dow, J., Wold, L. E., & Kloner, R. A. (2005) · Circulation · doi:10.1161/circulationaha.104.527937 · Cited by 539 · see citing works
Anker, P. S. I. `., Noort, W. A., Scherjon, S. A., der Keur, C. K., Kruisselbrink, A. B., van Bezooijen, R. L., Beekhuizen, W., Willemze, R., Kanhai, H. H. H., & Fibbe, W. E. (2003) · PubMed · Cited by 520 · see citing works
Jimenez, J. J., Jy, W., Mauro, L. M., Soderland, C., Horstman, L. L., & Ahn, Y. S. (2003) · Thrombosis Research · doi:10.1016/s0049-3848(03)00064-1 · Cited by 515 · see citing works
van Poll, D., Parekkadan, B., Cho, C. H., Berthiaume, F., Nahmias, Y., Tilles, A. W., & Yarmush, M. L. (2008) · Hepatology · doi:10.1002/hep.22236 · Cited by 501 · see citing works
André, F., Chaput, N., Schartz, N. E. C., Flament, C., Aubert, N., Bernard, J., Lemonnier, F., Raposo, G., Escudier, B., Hsu, D.-H., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2126 · Cited by 496 · see citing works
Noiseux, N., Gnecchi, M., Lopez-Ilasaca, M. A., Zhang, L., Solomon, S. D., Deb, A., Dzau, V. J., & Pratt, R. E. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.05.016 · Cited by 496 · see citing works
Miao, Z., Jin, J., Chen, L., Zhu, J., Huang, W., Zhao, J., Qian, H., & Zhang, X. (2006) · Cell Biology International · doi:10.1016/j.cellbi.2006.03.009 · Cited by 474 · see citing works
Hung, S.-C., Pochampally, R. R., Chen, S.-C., Hsu, S.-C., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0686 · Cited by 457 · see citing works
Zhou, H., Pisitkun, T., Aponte, A. M., Yuen, P. S. T., Hoffert, J. D., Yasuda, H., Hu, X., Chawla, L. S., Shen, R., Knepper, M. A., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5001874 · Cited by 446 · see citing works
A Quadripotential Mesenchymal Progenitor Cell Isolated from the Marrow of an Adult Mouse
Dennis, J. E., Merriam, A. P., Awadallah, A., Yoo, J. U., Johnstone, B., & Caplan, A. I. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.5.700 · Cited by 431 · see citing works
Timmers, L., Lim, S. K., Hoefer, I. E., Arslan, F., Lai, R. C., van Oorschot, A. A. M., Goumans, M., Strijder, C. F., Sze, S. K., Choo, A. B. H., et al. (2011) · Stem Cell Research · doi:10.1016/j.scr.2011.01.001 · Cited by 430 · see citing works
Potian, J. A., Aviv, H., Ponzio, N. M., Harrison, J. S., & Rameshwar, P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3426 · Cited by 426 · see citing works
Raposo, G., Tenza, D., Mecheri, S., Péronet, R., Bonnerot, C., & Desaymard, C. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2631 · Cited by 406 · see citing works
Iso, Y., Spees, J. L., Serrano, C., Bakondi, B., Pochampally, R. R., Song, Y., Sobel, B. E., Delafontaine, P., & Prockop, D. J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.045 · Cited by 403 · see citing works
Chen, T. S., Arslan, F., Yin, Y., Tan, S. S., Lai, R. C., Choo, A. B. H., Padmanabhan, J., Lee, C. N., de Kleijn, D. P. V., & Lim, S. K. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-47 · Cited by 398 · see citing works
Mesenchymal stem cells: progress toward promise
Blanc, K. L., & Pittenger, M. F. (2005) · Cytotherapy · doi:10.1016/s1465-3249(05)70787-8 · Cited by 388 · see citing works
Admyre, C., Grünewald, J., Thyberg, J., Gripenbäck, S., Tornling, G., Eklúnd, A., Scheynius, A., & Gabrielsson, S. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00041703 · Cited by 383 · see citing works
Higher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes
Fang, Y., Wu, N., Gan, X., Yan, W., Morrell, J. C., & Gould, S. J. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050158 · Cited by 382 · see citing works
Role of exosomes in sperm maturation during the transit along the male reproductive tract
Sullivan, R., Saez, F., Girouard, J., & Frenette, G. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.03.005 · Cited by 320 · see citing works
Perry, B. C., Zhou, D., Wu, X., Yang, F., Byers, M. A., Chu, T. G., Hockema, J. J., Woods, E. J., & Goebel, W. S. (2008) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2008.0031 · Cited by 301 · see citing works
Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes
Keller, S., König, A.-K., Marmé, F., Runz, S., Wolterink, S., Koensgen, D., Mustea, A., Sehouli, J., & Altevogt, P. (2009) · Cancer Letters · doi:10.1016/j.canlet.2008.12.028 · Cited by 298 · see citing works
Kohyama, J., Abe, H., Shimazaki, T., Koizumi, A., Nakashima, K., Gojo, S., Taga, T., Okano, H., Hata, J.-I., & Umezawa, A. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.680411.x · Cited by 295 · see citing works
Roubelakis, M. G., Pappa, K. I., Bitsika, V., Zagoura, D., Vlahou, A., Papadaki, H. Α., Antsaklis, A., & Anagnou, N. P. (2007) · Stem Cells and Development · doi:10.1089/scd.2007.0036 · Cited by 284 · see citing works
Protein Targeting to Exosomes/Microvesicles by Plasma Membrane Anchors
Shen, B., Wu, N., Yang, J.-M., & Gould, S. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208660 · Cited by 283 · see citing works
The microvesicle as a vehicle for EMMPRIN in tumor–stromal interactions
Sidhu, S., Mengistab, A., Tauscher, A. N., LaVail, J. H., & Basbaum, C. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207070 · Cited by 279 · see citing works
Exosomes as Biomarker Treasure Chests for Prostate Cancer
Duijvesz, D., Luider, T. M., Bangma, C. H., & Jenster, G. W. (2010) · European Urology · doi:10.1016/j.eururo.2010.12.031 · Cited by 278 · see citing works
Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells
Sze, S. K., de Kleijn, D. P. V., Lai, R. C., Tan, E. K. W., Zhao, H., Yeo, K. S., Low, T. Y., Lian, Q., Lee, C. N., Mitchell, W., et al. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600393-mcp200 · Cited by 266 · see citing works
Extracellular membrane vesicles from tumor cells promote angiogenesis via sphingomyelin.
Kim, C. W., Lee, H. M., Lee, T. H., Kang, C., Kleinman, H. K., & Gho, Y. S. (2002) · PubMed · Cited by 265 · see citing works
In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells
Gojo, S. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00132-0 · Cited by 257 · see citing works
First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis
Abrahams, V. M. (2003) · Molecular Human Reproduction · doi:10.1093/molehr/gah006 · Cited by 254 · see citing works
Peters, P. J., Geuze, H. J., van der Donk, H., Slot, J. W., Griffith, J. M., Stam, N. J., Clevers, H. C., & Borst, J. G. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190819 · Cited by 251 · see citing works
Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism
Qazi, K. R., Gehrmann, U., Jordö, E. D., Karlsson, M. C. I., & Gabrielsson, S. (2009) · Blood · doi:10.1182/blood-2008-04-153536 · Cited by 250 · see citing works
Wright, K. T., Masri, W. E., Osman, A., Chowdhury, J. R., & Johnson, W. E. B. (2010) · Stem Cells · doi:10.1002/stem.570 · Cited by 220 · see citing works
Selective delivery of doxorubicin to patients with breast carcinoma metastases by stealth liposomes
Symon, Z., PEYSER, A. B., Tzemach, D., Lyass, O., Sucher, E., Shezen, E., & Gabizón, A. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990701)86:1 · Cited by 214 · see citing works
Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T‐cell lymphoma
Wollina, U., Dummer, R., Brockmeyer, N. H., Konrad, H., Busch, J., Kaatz, M., Knopf, B., Koch, H., & Hauschild, A. (2003) · Cancer · doi:10.1002/cncr.11593 · Cited by 214 · see citing works
T cell exosomes induce cholesterol accumulation in human monocytes via phosphatidylserine receptor
Zakharova, L., Svetlova, M., & Fomina, A. F. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21013 · Cited by 209 · see citing works
Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells
Gotherstrom, C. O. T., Ringdén, O. T. H., Westgren, M., Tammik, C., & Blanc, K. L. (2003) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704111 · Cited by 203 · see citing works
Batagov, A. O., Kuznetsov, V. A., & Kurochkin, I. V. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-s3-s18 · Cited by 178 · see citing works
Kobayashi, T., Hamano, K., Li, T., Katoh, T., Kobayashi, S., Matsuzaki, M., & Esato, K. (2000) · Journal of Surgical Research · doi:10.1006/jsre.2000.5828 · Cited by 170 · see citing works
A Novel Liposomal Bupivacaine Formulation to Produce Ultralong-Acting Analgesia
Grant, G. J., Barenholz, Y., Bolotin, E. M., Bansinath, M., Turndorf, H., Piskoun, B., & Davidson, E. M. (2004) · Anesthesiology · doi:10.1097/00000542-200407000-00021 · Cited by 170 · see citing works
Exosomes as a Tumor Vaccine: Enhancing Potency Through Direct Loading of Antigenic Peptides
Hsu, D., PAZ, P. E., Villaflor, G., Rivas, A., Mehta-Damani, A., Angevin, E., Zitvogel, L., & Pecq, J. L. (2003) · Journal of Immunotherapy · doi:10.1097/00002371-200309000-00007 · Cited by 168 · see citing works
The immunomodulatory properties of mesenchymal stem cells
Marigo, I., & Dazzi, F. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0267-7 · Cited by 168 · see citing works
Zwaal, R. F. A., Comfurius, P., & Bevers, E. M. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(92)90019-j · Cited by 163 · see citing works
Li, L., Zhang, S., Zhang, Y., Yu, B., Xu, Y., & Guan, Z. (2008) · Molecular Biology Reports · doi:10.1007/s11033-008-9235-2 · Cited by 153 · see citing works
Human Umbilical Mesenchymal Stem Cells Promote Recovery After Ischemic Stroke
Lin, Y., Ko, T.-L., Shih, Y., Lin, M.-Y. A., Fu, T.-W., Hsiao, H.-S., Hsu, J.-Y. C., & Fu, Y.-S. (2011) · Stroke · doi:10.1161/strokeaha.110.603621 · Cited by 152 · see citing works
Lai, R. C., Arslan, F., Tan, S. S., Tan, B., Choo, A. B. H., Lee, M. M., Chen, T. S., Teh, B. J., Eng, J. K. L., Sidik, H., et al. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.12.021 · Cited by 152 · see citing works
Sundar, S., Jha, T. K., Thakur, C. P., Mishra, M., Singh, V. P., & Buffels, R. (2003) · Clinical Infectious Diseases · doi:10.1086/377542 · Cited by 134 · see citing works
Bhansali, A. K., Upreti, V., Khandelwal, N. K., Marwaha, N., Gupta, V., Sachdeva, N. K., Sharma, R. R., Saluja, K., Dutta, P. R., Walia, R., et al. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0164 · Cited by 130 · see citing works
Phase II Trial Of Pegylated-liposomal Doxorubicin (Doxil™) In Sarcoma*
Skubitz, K. M. (2003) · Cancer Investigation · doi:10.1081/cnv-120016412 · Cited by 122 · see citing works
Pegylated Liposomal Doxorubicin in the Treatment of Breast Cancer
O’Shaughnessy, J. (2003) · Clinical Breast Cancer · doi:10.3816/cbc.2003.n.037 · Cited by 115 · see citing works
Perez, A., Domenech, G. H., Frankel, C., & Vogel, C. L. (2002) · Cancer Investigation · doi:10.1081/cnv-120014883 · Cited by 114 · see citing works
Erices, A. A., Allers, C., Conget, P. A., Rojas, C., & Minguell, J. J. (2003) · Cell Transplantation · doi:10.3727/000000003108747154 · Cited by 109 · see citing works
Simpson, R. J., & Mathivanan, S. (2012) · Journal of Proteomics & Bioinformatics · doi:10.4172/jpb.10000e10 · Cited by 90 · see citing works
Mesenchymal progenitor cells derived from traumatized human muscle
Jackson, W. M., Aragon, A. B., Djouad, F., Song, Y., Koehler, S. M., Nesti, L. J., & Tuan, R. S. (2009) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.149 · Cited by 85 · see citing works
Seiden, M. V., Muggia, F. M., Astrow, A., Matulonis, U. A., Campos, S., Roche, M. R., Sivret, J., Rusk, J., & Barrett, E. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.12.037 · Cited by 84 · see citing works
Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer
Quah, B., Barlow, V., McPhun, V., MATTHAEI, K. I., Hulett, M. D., & Parish, C. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800259105 · Cited by 71 · see citing works
Liposomal doxorubicin and weekly paclitaxel in the treatment of metastatic breast cancer
Schwonzen, M., Kurbacher, C. M., & Mallmann, P. K. (2000) · Anti-Cancer Drugs · doi:10.1097/00001813-200010000-00002 · Cited by 66 · see citing works
Harrington, K. J., Lewanski, C. R., Northcote, A. D., Whittaker, J., Peters, A. M., Vile, R. G., & Stewart, J. S. W. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00216-7 · Cited by 65 · see citing works
Sato, T., Iso, Y., Uyama, T., Kawachi, K., Wakabayashi, K., Omori, Y., Soda, T., Shoji, M., Koba, S., Yokoyama, S., et al. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2010.202 · Cited by 64 · see citing works
Johnston, S. R. D., & Gore, M. E. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00329-x · Cited by 60 · see citing works
Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death
Keller, J. N., & Markesbery, W. R. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4 · Cited by 54 · see citing works
Schmidinger, M., Wenzel, C.-K., Locker, G. J., Muehlbacher, F., Steininger, R., Gnant, M., Crevenna, R., & Budinsky, A. C. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2149 · Cited by 35 · see citing works
Gonçalvès, A., Braud, A. C., Viret, F., Genre, D., Gravis, G., Tarpin, C., Giovannini, M. F., Maraninchi, D., & Viens, P. (2003) · PubMed · Cited by 30 · see citing works
Platelet-derived exosomes: a new vascular redox signaling pathway
Carmo, A., Pedro, M., Silva, E., Knobel, E., Laurindo, F., & Janiszewski, M. (2003) · Critical Care · doi:10.1186/cc2313 · Cited by 4 · see citing works
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Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,254 · see citing works
Doyle, L. M., & Wang, M. Z. (2019) · Cells · doi:10.3390/cells8070727 · Cited by 3,271 · see citing works
Exosomes as drug delivery vehicles for Parkinson’s disease therapy
Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009 · see citing works
Ha, D., Yang, N., & Nadithe, V. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.02.001 · Cited by 1,346 · see citing works
Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications
Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.44 · Cited by 1,233 · see citing works
Using exosomes, naturally-equipped nanocarriers, for drug delivery
Batrakova, E. V., & Kim, M. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.030 · Cited by 1,122 · see citing works
Yang, T., Martin, P. B., Fogarty, B., Brown, A. H., Schurman, K., Phipps, R. J., Yin, V. P., Lockman, P. R., & Bai, S. (2015) · Pharmaceutical Research · doi:10.1007/s11095-014-1593-y · Cited by 980 · see citing works
Bovine milk-derived exosomes for drug delivery
Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.020 · Cited by 936 · see citing works
Pascucci, L., Coccè, V., Bonomi, A., Ami, D., Ceccarelli, P., Ciusani, E., Viganò, L., Locatelli, A., Sisto, F., Doglia, S. M., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.042 · Cited by 907 · see citing works
Exosomes Derived from Mesenchymal Stem Cells
Yu, B., Zhang, X., & Li, X. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15034142 · Cited by 788 · see citing works
Fuhrmann, G., Serio, A., Mazo, M. M., Nair, R., & Stevens, M. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.029 · Cited by 746 · see citing works
Xin, H., Li, Y., Liu, Z., Wang, X., Shang, X., Cui, Y., Zhang, Z. G., & Chopp, M. (2013) · Stem Cells · doi:10.1002/stem.1409 · Cited by 724 · see citing works
Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake
Gebologlu, I. K., & Öncel, S. Ş. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.027 · Cited by 703 · see citing works
Willis, G. R., Fernandez‐Gonzalez, A., Anastas, J. N., Vitali, S. H., Liu, X., Ericsson, M., Kwong, A., Mitsialis, S. A., & Kourembanas, S. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201705-0925oc · Cited by 631 · see citing works
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
Hade, M. D., Suire, C. N., & Suo, Z. (2021) · Cells · doi:10.3390/cells10081959 · Cited by 627 · see citing works
Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 618 · see citing works
Exosomes and their roles in immune regulation and cancer
Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.009 · Cited by 608 · see citing works
Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
Lou, G., Chen, Z., Zheng, M., & Liu, Y. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.63 · Cited by 605 · see citing works
Imai, T., Takahashi, Y., Nishikawa, M., Kato, K., Morishita, M., Yamashita, T., Matsumoto, A., Charoenviriyakul, C., & Takakura, Y. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26238 · Cited by 584 · see citing works
Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders
Riazifar, M., Mohammadi, M. R., Pone, E. J., Yeri, A., Lässer, C., Segaliny, A. I., McIntyre, L. L., Shelke, G. V., Hutchins, E., Hamamoto, A., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01004 · Cited by 551 · see citing works
Exosomes: From Garbage Bins to Promising Therapeutic Targets
Rashed, M. H., Bayraktar, E., Helal, G. K., Abd‐Ellah, M. F., Amero, P., Chávez‐Reyes, A., & Rodriguez‐Aguayo, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030538 · Cited by 525 · see citing works
Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483 · see citing works
Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy
Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b06939 · Cited by 482 · see citing works
Paracrine Mechanisms of Mesenchymal Stem Cells in Tissue Repair
Gnecchi, M., Danieli, P., Malpasso, G., & Ciuffreda, M. C. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3584-0_7 · Cited by 456 · see citing works
Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain
Patel, M. M., & Patel, B. M. (2017) · CNS Drugs · doi:10.1007/s40263-016-0405-9 · Cited by 430 · see citing works
Lamichhane, T. N., Raiker, R. S., & Jay, S. M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00364 · Cited by 413 · see citing works
Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide
Vandergriff, A. C., Huang, K., Shen, D., Hu, S., Hensley, M. T., Caranasos, T. G., Li, Q., & Cheng, K. (2018) · Theranostics · doi:10.7150/thno.20524 · Cited by 407 · see citing works
In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles
Betzer, O., Perets, N., Angel, A., Motiei, M., Sadan, T., Yadid, G., Offen, D., & Popovtzer, R. (2017) · ACS Nano · doi:10.1021/acsnano.7b04495 · Cited by 404 · see citing works
Hu, G., Li, Q., Niu, X., Hu, B., Liu, J., Zhou, S.-M., Guo, S., Lang, H., Zhang, C., Wang, Y., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/scrt546 · Cited by 394 · see citing works
Regulation of exosome production and cargo sorting
Wei, H., Chen, Q., Lin, L., Sha, C., Li, T., Liu, Y., Yin, X., Xu, Y., Chen, L., Gao, W., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.53671 · Cited by 385 · see citing works
Perets, N., Betzer, O., Shapira, R., Brenstein, S., Angel, A., Sadan, T., Ashery, U., Popovtzer, R., & Offen, D. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b04148 · Cited by 382 · see citing works
Recent advances in siRNA delivery mediated by lipid-based nanoparticles
Yonezawa, S., Koide, H., & Asai, T. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.022 · Cited by 386 · see citing works
Zhang, L., Jiao, G., Ren, S., Zhang, X., Li, C., Wu, W., Wang, H., Liu, H., Zhou, H., & Chen, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-1562-9 · Cited by 361 · see citing works
Sun, G., Li, G., Li, D., Huang, W., Zhang, R., Zhang, H., Duan, Y., & Wang, B. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.04.006 · Cited by 314 · see citing works
Exosomes/miRNAs as mediating cell-based therapy of stroke
Xin, H., Li, Y., & Chopp, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00377 · Cited by 302 · see citing works
Nakase, I., & Futaki, S. (2015) · Scientific Reports · doi:10.1038/srep10112 · Cited by 297 · see citing works
Shigemoto-Kuroda, T., Oh, J. Y., Kim, D.-K., Jeong, H. J., Park, S. Y., Lee, H. J., Park, J. W., Kim, T. W., An, S. Y., Prockop, D. J., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.04.008 · Cited by 297 · see citing works
Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Borges, F. T., Reis, L. A., & Schor, N. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20132964 · Cited by 294 · see citing works
Bioinspired exosome-like therapeutics and delivery nanoplatforms
Lu, M., & Huang, Y. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119925 · Cited by 282 · see citing works
Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes
Wan, Y., Cheng, G., Liu, X., Hao, S.-J., Nisic, M., Zhu, C.-D., Xia, Y.-Q., Li, W.-Q., Wang, Z., Zhang, W.-L., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0058 · Cited by 280 · see citing works
Li, Z., Liu, F., He, X., Yang, X., Shan, F., & Feng, J. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.001 · Cited by 280 · see citing works
Bjørge, I. M., Kim, S. Y., Mano, J. F., Kalionis, B., & Chrzanowski, W. (2017) · Biomaterials Science · doi:10.1039/c7bm00479f · Cited by 276 · see citing works
Nakase, I., Kobayashi, N. B., Takatani‐Nakase, T., & Yoshida, T. (2015) · Scientific Reports · doi:10.1038/srep10300 · Cited by 271 · see citing works
Jiang, Z.-Z., Liu, Y., Niu, X., Yin, J., Hu, B., Guo, S., Fan, Y., Wang, Y., & Wang, N. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0287-2 · Cited by 271 · see citing works
Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery
Parodi, A., Molinaro, R., Sushnitha, M., Evangelopoulos, M., Martinez, J. O., Arrighetti, N., Corbo, C., & Tasciotti, E. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.020 · Cited by 265 · see citing works
Huda, M. N., Nafiujjaman, M., Deaguero, I. G., Okonkwo, J., Hill, M. L., Kim, T. H., & Nurunnabi, M. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00217 · Cited by 262 · see citing works
A Comparison of Traditional and Novel Methods for the Separation of Exosomes from Human Samples
Yu, L., Zhu, J., Liu, J., Jiang, F., Ni, W., Qu, L., Ni, R., Lu, C., & Xiao, M. (2018) · BioMed Research International · doi:10.1155/2018/3634563 · Cited by 246 · see citing works
Liposome-like nanostructures for drug delivery
Gao, W., Hu, C. J., Fang, R. H., & Zhang, L. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21238f · Cited by 246 · see citing works
MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury
Yang, Y., Ye, Y., Su, X., He, J., Bai, W., & He, X. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00055 · Cited by 236 · see citing works
Emerging Roles for Extracellular Vesicles in Tissue Engineering and Regenerative Medicine
Lamichhane, T. N., Sokic, S., Schardt, J. S., Raiker, R. S., Lin, J. W., & Jay, S. M. (2014) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2014.0300 · Cited by 229 · see citing works
A comprehensive review of challenges and advances in exosome-based drug delivery systems
Palakurthi, S. S., Shah, B. M., Kapre, S., Charbe, N. B., Immanuel, S., Pasham, S., Thalla, M., Jain, A., & Palakurthi, S. (2024) · Nanoscale Advances · doi:10.1039/d4na00501e · Cited by 246 · see citing works
Exosomes: novel effectors of human platelet lysate activity
Torreggiani, E., Perut, F., Roncuzzi, L., Zini, N., Baglio, S. R., & Baldini, N. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a11 · Cited by 215 · see citing works
Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma
Du, Y., Zhuansun, Y., Chen, R., Lin, L., Lin, Y., & Li, J. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.12.021 · Cited by 215 · see citing works
Cao, H., Cheng, Y., Gao, H., Zhuang, J., Zhang, W., Bian, Q., Wang, F., Du, Y., Li, Z., Kong, D., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b08207 · Cited by 217 · see citing works
Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics
Kar, R., Dhar, R., Mukherjee, S., Nag, S., Gorai, S., Mukerjee, N., Mukherjee, D., Vatsa, R., Jadhav, M., Ghosh, A., et al. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01329 · Cited by 217 · see citing works
Mardpour, S., Ghanian, M. H., Sadeghi-abandansari, H., Mardpour, S., Nazari, A., Shekari, F., & Baharvand, H. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10126 · Cited by 211 · see citing works
Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes
Wan, S., Zhang, L., Wang, S., Liu, Y., Wu, C. S., Cui, C., Sun, H. R., Shi, M., Jiang, Y. Y., Li, L., et al. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b00319 · Cited by 209 · see citing works
Recent advances in innovative strategies for enhanced cancer photodynamic therapy
Hu, T., Wang, Z., Shen, W., Liang, R., Yan, D., & Wei, M. (2021) · Theranostics · doi:10.7150/thno.54227 · Cited by 210 · see citing works
Kuang, Y., Zheng, X., Zhang, L., Ai, X., Venkataramani, V., Kılıç, E., Hermann, D. M., Majid, A., Bähr, M., & Doeppner, T. R. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12024 · Cited by 203 · see citing works
Yang, T., Fogarty, B., LaForge, B., Aziz, S., Pham, T., Lai, L., & Bai, S. (2017) · The AAPS Journal · doi:10.1208/s12248-016-0015-y · Cited by 204 · see citing works
Yan, F., Zhong, Z., Wang, Y., Feng, Y., Mei, Z., Li, H., Chen, X., Cai, L., & Li, C. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00675-6 · Cited by 197 · see citing works
Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes
Tschuschke, M., Kocherova, I., Bryja, A., Mozdziak, P. E., Volponi, A. A., Janowicz, K., Sibiak, R., Piotrowska‐Kempisty, H., Iżycki, D., Bukowska, D., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020436 · Cited by 197 · see citing works
Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy
Cheng, L., Zhang, K., Wu, S., Cui, M., & Xu, T. (2017) · Stem Cells International · doi:10.1155/2017/6305295 · Cited by 192 · see citing works
Salivary Exosomes: Emerging Roles in Systemic Disease
Han, Y., Jia, L., Zheng, Y., & Li, W. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.25018 · Cited by 193 · see citing works
Exosomes and their role in tumorigenesis and anticancer drug resistance
Milman, N., Ginini, L., & Gil, Z. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.07.003 · Cited by 192 · see citing works
Rodrigues, M., Fan, J., Lyon, C., Wan, M., & Hu, Y. (2018) · Theranostics · doi:10.7150/thno.20576 · Cited by 191 · see citing works
Shirejini, S. Z., & İnci, F. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107814 · Cited by 192 · see citing works
Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential
Al-Ghadban, S. I., & Bunnell, B. A. (2020) · Physiology · doi:10.1152/physiol.00021.2019 · Cited by 190 · see citing works
Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases
Tran, T.-H., Mattheolabakis, G., Aldawsari, H. M., & Amiji, M. M. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.03.021 · Cited by 186 · see citing works
Mesenchymal stem cells-derived exosomes for drug delivery
Sun, Y., Liu, G., Zhang, K., Cao, Q., Liu, T., & Li, J. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02629-7 · Cited by 184 · see citing works
Nakase, I., Noguchi, K., Aoki, A., Takatani‐Nakase, T., Fujii, I., & Futaki, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02014-6 · Cited by 180 · see citing works
García‐Manrique, P., Matos, M., Gutiérrez, G., Pazos, C., & Blanco‐López, M. C. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1422676 · Cited by 180 · see citing works
Desale, K., Kuche, K., & Jain, S. (2020) · Biomaterials Science · doi:10.1039/d0bm01755h · Cited by 185 · see citing works
Wen, D., Peng, Y., Liu, D., Weizmann, Y., & Mahato, R. I. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.044 · Cited by 180 · see citing works
Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications
Madni, A., Sarfraz, M., Rehman, M., Ahmad, M., Akhtar, N., Ahmad, S., Tahir, N., Ijaz, S., Al‐Kassas, R., & Löbenberg, R. (2014) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3cp55 · Cited by 178 · see citing works
Ding, Y., Cao, F., Sun, H., Wang, Y., Liu, S., Wu, Y., Cui, Q., Mei, W., & Li, F. (2019) · Cancer Letters · doi:10.1016/j.canlet.2018.10.039 · Cited by 177 · see citing works
Immunotherapeutic Potential of Extracellular Vesicles
Zhang, B., Yin, Y., Lai, R. C., & Lim, S. K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00518 · Cited by 173 · see citing works
Dou, G., Tian, R., Liu, X., Yuan, P., Ye, Q., Liu, J., Liu, S., Zhou, J., Deng, Z., Chen, X., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba2987 · Cited by 173 · see citing works
Stem cell therapy without the cells
Maguire, G. (2013) · Communicative & Integrative Biology · doi:10.4161/cib.26631 · Cited by 172 · see citing works
Piktel, E., Niemirowicz, K., Wątek, M., Wollny, T., Deptuła, P., & Bucki, R. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0193-x · Cited by 171 · see citing works
Pan, S., Pei, L., Zhang, A., Zhang, Y., Zhang, C., Huang, M., Huang, Z., Liu, B., Wang, L., Ma, L., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119606 · Cited by 170 · see citing works
Extracellular vesicles from infected cells: potential for direct pathogenesis
Schwab, A., Meyering, S. S., Lepene, B., Iordanskiy, S., van Hoek, M. L., Hakami, R. M., & Kashanchi, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01132 · Cited by 160 · see citing works
From structures to functions: insights into exosomes as promising drug delivery vehicles
Ren, J., He, W., Zheng, L., & Duan, H. (2016) · Biomaterials Science · doi:10.1039/c5bm00583c · Cited by 161 · see citing works
Ma, X., Huang, M., Zheng, M., Dai, C., Song, Q., Zhang, Q., Li, Q., Gu, X. Q., Chen, H., Jiang, G., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.019 · Cited by 162 · see citing works
Inhibition of Glioma Cells’ Proliferation by Doxorubicin-Loaded Exosomes via Microfluidics
Thakur, A., Sidu, R. K., Zou, H., Alam, M. K., Yang, M., & Lee, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s263956 · Cited by 162 · see citing works
Exosomes and stem cells in degenerative disease diagnosis and therapy
Chang, Y.-H., Wu, K.-C., Harn, H.-J., Lin, S.-Z., & Ding, D.-C. (2018) · Cell Transplantation · doi:10.1177/0963689717723636 · Cited by 159 · see citing works
Neuroinflammation, Bone Marrow Stem Cells, and Chronic Pain
Huh, Y., Ji, R., & Chen, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01014 · Cited by 159 · see citing works
Exosomes: Diagnostic Biomarkers and Therapeutic Delivery Vehicles for Cancer
Jiang, L., Gu, Y., Du, Y., & Liu, J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00409 · Cited by 158 · see citing works
Shamili, F. H., Alibolandi, M., Rafatpanah, H., Abnous, K., Mahmoudi, M., Kalantari, M. R., Taghdisi, S. M., & Ramezani, M. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.032 · Cited by 157 · see citing works
Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges
Fuhrmann, G., Herrmann, I. K., & Stevens, M. M. (2015) · Nano Today · doi:10.1016/j.nantod.2015.04.004 · Cited by 155 · see citing works
Tang, X., Sun, X., Huang, K.-M., Zhang, L., Yang, Z., Zou, D., Wang, B., Warnock, G. L., Dai, L., & Luo, J. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6175 · Cited by 157 · see citing works
Haney, M. J., Klyachko, N. L., Harrison, E. B., Zhao, Y., Kabanov, A. V., & Batrakova, E. V. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801271 · Cited by 151 · see citing works
Marolt, D., Traweger, A., Gimona, M., & Redl, H. R. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00352 · Cited by 152 · see citing works
Kanchanapally, R., Deshmukh, S. K., Chavva, S. R., Tyagi, N., Srivastava, S. K., Patel, G. K., Singh, A. P., & Singh, S. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s191313 · Cited by 150 · see citing works
Novel insights into MSC-EVs therapy for immune diseases
Lai, P., Weng, J., Guo, L., Chen, X., & Du, X. (2019) · Biomarker Research · doi:10.1186/s40364-019-0156-0 · Cited by 143 · see citing works
Zheng, G., Huang, R., Qiu, G., Ge, M., Wang, J., Shu, Q., & Xu, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2871-5 · Cited by 143 · see citing works
The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications
Zheng, H., Zhan, Y., Liu, S., Lu, J., Luo, J., Feng, J., & Fan, S. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0901-5 · Cited by 140 · see citing works
Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair
Liu, X., Li, X., Zhu, W., Zhang, Y., Hong, Y., Liang, X., Fan, B., Zhao, H., He, H., & Zhang, F. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29456 · Cited by 138 · see citing works
Nooshabadi, V. T., Mardpour, S., Yousefi‐Ahmadipour, A., Allahverdi, A., Izadpanah, M., Daneshimehr, F., Ai, J., Banafshe, H. R., & Ebrahimi‐Barough, S. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26726 · Cited by 133 · see citing works
Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations
Klyachko, N. L., Arzt, C. J., Li, S. M., Gololobova, O. A., & Batrakova, E. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121171 · Cited by 132 · see citing works
- Authors
- Lai, R. C., Yeo, R. W. Y., Tan, K. H., & Lim, S. K.
- Affiliations
- Agency for Science, Technology and Research (SG)
- KK Women's and Children's Hospital (SG)
- Corresponding author
- Lim, Sai Kiang
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 31
- Issue
- 5
- Pages
- 543-551
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W2010746084
- Cited by
- 546
- References
- 136
- Citations by year
- 2026: 17 · 2025: 41 · 2024: 40 · 2023: 50 · 2022: 54 · 2021: 63 · 2020: 62 · 2019: 51 · 2018: 44 · 2017: 32 · 2016: 23 · 2015: 29 · 2014: 21 · 2013: 16
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- exosomes, drug delivery, mesenchymal stem cells, membrane vesicles, stem cell transplantation, exosome production, intercellular communication, immunogenicity
- MeSH terms
- Animals, Cells, Cultured, Humans, Drug Delivery Systems, Mesenchymal Stem Cell Transplantation, Exosomes, Mesenchymal Stem Cells
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