The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
SHED Differentiate into Functional Odontoblasts and Endothelium
Abstract
Studies on mechanisms underlying the differentiation of dental pulp stem cells are critical for the understanding of the biology of odontogenesis and for dental tissue engineering. Here, we tested the hypothesis that stem cells from exfoliated deciduous teeth (SHED) differentiate into functional odontoblasts and endothelial cells. SHED were seeded in tooth slice/scaffolds and implanted subcutaneously into immunodeficient mice. SHED differentiated into functional odontoblasts that generated tubular dentin, as determined by tetracycline staining and confocal microscopy. These cells also differentiated into vascular endothelial cells, as determined by beta-galactosidase staining of LacZ-tagged SHED. In vitro, vascular endothelial growth factor (VEGF) induced SHED to express VEGFR2, CD31, and VE-Cadherin (markers of endothelium) and to organize into capillary-like sprouts. VEGF induced ERK and AKT phosphorylation (indicative of differentiation), while inhibiting phosphorylation of STAT3 (indicative of ‘stemness’). Collectively, this work demonstrates that SHED can differentiate into angiogenic endothelial cells and odontoblasts capable of generating tubular dentin.
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Cites
The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
Gronthos, S., Mankani, M., Brahim, J., Robey, P. G., & Shi, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240309797 · Cited by 4,570
Self-citationSHED: Stem cells from human exfoliated deciduous teeth
Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, L. W., Robey, P. G., & Shi, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937635100 · Cited by 2,988
Self-citationSelf-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
Niwa, H., Burdon, T., Chambers, I., & Smith, A. (1998) · Genes & Development · doi:10.1101/gad.12.13.2048 · Cited by 1,549
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
Matsuda, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4261 · Cited by 895
Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth
Cordeiro, M. M., Dong, Z., Kaneko, T., Zhang, Z., Miyazawa, M., Shi, S., Smith, A. J., & Nör, J. E. (2008) · Journal of Endodontics · doi:10.1016/j.joen.2008.04.009 · Cited by 668
Self-citationNör, J. E., Christensen, J., Mooney, D. J., & Polverini, P. J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65284-4 · Cited by 641
Self-citationHuang, G. T.-J., Yamaza, T., Shea, L. D., Djouad, F., Kuhn, N. Z., Tuan, R. S., & Shi, S. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0518 · Cited by 610
Self-citationd'Aquino, R., Graziano, A., Sampaolesi, M., Laino, G., Pirozzi, G., De Rosa, A., & Papaccio, G. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402121 · Cited by 518
MacDougall, M., Simmons, D., Luan, X., Nydegger, J., Feng, J., & Gu, T. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.835 · Cited by 437
Cited by
Dentin Conditioning Codetermines Cell Fate in Regenerative Endodontics
Galler, K. M., D’Souza, R. N., Federlin, M., Cavender, A. C., Hartgerink, J. D., Hecker, S., & Schmalz, G. (2011) · Journal of Endodontics · doi:10.1016/j.joen.2011.08.027 · Cited by 323
Metadata
- Authors
- Sakai, V. T., Zhang, Z., Dong, Z., Neiva, K. G., Machado, M. A. A. M., Shi, S., Santos, C. F., & Nör, J. E.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-04-15
- Volume
- 89
- Issue
- 8
- Pages
- 791-796
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2171537081
- Cited by
- 423
- References
- 23
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sakai, V. T., Zhang, Z., Dong, Z., Neiva, K. G., Machado, M. A. A. M., Shi, S., Santos, C. F., & Nör, J. E. (2010). SHED Differentiate into Functional Odontoblasts and Endothelium. Journal of Dental Research. https://doi.org/10.1177/0022034510368647
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
