The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
SHED: Stem cells from human exfoliated deciduous teeth
Open accessAbstract
To isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human deciduous tooth contains multipotent stem cells [ s tem cells from h uman e xfoliated d eciduous teeth (SHED)]. SHED were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. After in vivo transplantation, SHED were found to be able to induce bone formation, generate dentin, and survive in mouse brain along with expression of neural markers. Here we show that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells. SHED are not only derived from a very accessible tissue resource but are also capable of providing enough cells for potential clinical application. Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering.
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Changing potency by spontaneous fusion
Ying, Q.-L., Nichols, J., Evans, E. P., & Smith, A. G. (2002) · Nature · doi:10.1038/nature729 · Cited by 1,494
Cited by
Mesenchymal stem cell perspective: cell biology to clinical progress
Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0083-6 · Cited by 2,008
Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth
Cordeiro, M. M., Dong, Z., Kaneko, T., Zhang, Z., Miyazawa, M., Shi, S., Smith, A. J., & Nör, J. E. (2008) · Journal of Endodontics · doi:10.1016/j.joen.2008.04.009 · Cited by 668
Self-citationRegenerative endodontics: a comprehensive review
Kim, S. G., Malek, M., Sigurdsson, A., Lin, L. M., & Kahler, B. (2018) · International Endodontic Journal · doi:10.1111/iej.12954 · Cited by 523
SHED Differentiate into Functional Odontoblasts and Endothelium
Sakai, V. T., Zhang, Z., Dong, Z., Neiva, K. G., Machado, M. A. A. M., Shi, S., Santos, C. F., & Nör, J. E. (2010) · Journal of Dental Research · doi:10.1177/0022034510368647 · Cited by 423
Self-citationIsolation and characterization of multipotent human periodontal ligament stem cells
Gay, I., Chen, S., & MacDougall, M. (2007) · Orthodontics & Craniofacial Research · doi:10.1111/j.1601-6343.2007.00399.x · Cited by 420
Metadata
- Authors
- Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, L. W., Robey, P. G., & Shi, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-04-25
- Volume
- 100
- Issue
- 10
- Pages
- 5807-5812
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2116864112
- Cited by
- 2,988
- References
- 4
- FWCI
- 18.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, L. W., Robey, P. G., & Shi, S. (2003). SHED: Stem cells from human exfoliated deciduous teeth. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0937635100
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