The DOI matches its Crossref record; 292 of the 292 references it cites were found in a registry or an index.
“ Gum Bug, Leave My Heart Alone !”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis
Open accessAbstract
Evidence from epidemiologic studies suggests that periodontal infections are independently associated with subclinical and clinical atherosclerotic vascular disease. Although the strength of the reported associations is modest, the consistency of the data across diverse populations and a variety of exposure and outcome variables suggests that the findings are not spurious or attributable only to the effects of confounders. Analysis of limited data from interventional studies suggests that periodontal treatment generally results in favorable effects on subclinical markers of atherosclerosis, although such analysis also indicates considerable heterogeneity in responses. Experimental mechanistic in vitro and in vivo studies have established the plausibility of a link between periodontal infections and atherogenesis, and have identified biological pathways by which these effects may be mediated. However, the utilized models are mostly mono-infections of host cells by a limited number of ‘model’ periodontal pathogens, and therefore may not adequately portray human periodontitis as a polymicrobial, biofilm-mediated disease. Future research must identify in vivo pathways in humans that may (i) lead to periodontitis-induced atherogenesis, or (ii) result in treatment-induced reduction of atherosclerosis risk. Data from these studies will be essential for determining whether periodontal interventions have a role in the primary or secondary prevention of atherosclerosis.
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“Periodontitis is a local inflammation and a source of low-grade chronic inflammation, which results from haematogenous dissemination of periodontal bacteria or spillover of inflammatory mediators from periodontal tissues to the bloodstream [4, 9], thus contributing to the systemic inflammatory burden, increasing the risk of several chronic diseases like CVD, type II diabetes mellitus (T2DM), renal”
From Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis (2024) · cites this paper as [9]
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Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
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“…from haematogenous dissemination of periodontal bacteria or spillover of inflammatory mediators from periodontal tissues to the bloodstream [4, 9], thus contributing to the systemic inflammatory burden, increasing the risk of several chronic diseases like CVD, type II diabetes mellitus…”
Background
Metadata
- Authors
- Kebschull, M., Demmer, R. T., & Papapanou, P. N.
- Affiliations
- University of Bonn (DE)
- Columbia University (US)
- Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, 630 W 168th Street, PH-7-E-110
- Corresponding author
- Papapanou, P.N.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-07-16
- Volume
- 89
- Issue
- 9
- Pages
- 879-902
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC3318075
- OpenAlex
- W2095060158
- Cited by
- 429
- References
- 292
- Citations by year
- 2026: 8 · 2025: 25 · 2024: 27 · 2023: 27 · 2022: 26 · 2021: 35 · 2020: 26 · 2019: 24 · 2018: 28 · 2017: 28 · 2016: 21 · 2015: 30 · 2014: 30 · 2013: 40 · 2012: 26
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (DE-015649, R01DE015649, K99DE018739, R00DE018739)
- National Center for Research Resources (RR025158)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- periodontal infection, periodontitis, atherosclerosis, atherogenesis, subclinical atherosclerosis, periodontal treatment, polymicrobial biofilms, periodontal pathogens, vascular risk
- MeSH terms
- Animals, Brain Ischemia, Coronary Disease, Disease Models, Animal, Endothelium, Vascular, Humans, Monocytes, Periodontitis, Platelet Aggregation, Smoking, Lipid Peroxidation, Autoimmunity, Confounding Factors, Epidemiologic, Effect Modifier, Epidemiologic, Bacteremia, Oxidative Stress, Stroke, Atherosclerosis, Toll-Like Receptors
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