The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases
Abstract
Aging is a biological process characterized by time-dependent functional declines that are influenced by changes in redox status and by oxidative stress-induced inflammatory reactions. An organism’s pro-inflammatory status may underlie the aging process and age-related diseases. In this review, we explore the molecular basis of low-grade, unresolved, subclinical inflammation as a major risk factor for exacerbating the aging process and age-related diseases. We focus on the redox-sensitive transcription factors, NF-κB and FOXO, which play essential roles in the expression of pro-inflammatory mediators and anti-oxidant enzymes, respectively. Major players in molecular inflammation are discussed with respect to the age-related up-regulation of pro-inflammatory cytokines and adhesion molecules, cyclo-oxygenase-2, lipoxygenase, and inducible nitric oxide synthase. The molecular inflammation hypothesis proposed by our laboratory is briefly described to give further molecular insights into the intricate interplay among redox balance, pro-inflammatory gene activation, and chronic age-related inflammatory diseases. The final section discusses calorie restriction as an aging-retarding intervention that also exhibits extraordinarily effective anti-inflammatory activity by modulating GSH redox, NF-κB, SIRT1, PPARs, and FOXOs.
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Citations
Cites
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 1×
“Stimulation by several factors, such as cytokines, induces NF-κB activation by IKK, which subsequently targets IκB for ubiquitination and degradation through the 26S proteasome (Ghosh and Karin, 2002).”
BackgroundModulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Self-citationForkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580
Extrachromosomal rDNA circles—a cause of aging in yeast
Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410
(2004) · doi:10.1016/s0092-8674(04)00452-0 · Cited by 1,356
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 1×
“CR increases the expression of SIRT1 in liver, adipose tissue, brain, and kidney (Cohen et al., 2004; Picard et al., 2004; Nisoli et al., 2005).”
Background
Cited by
Aging and age‐related diseases: from mechanisms to therapeutic strategies
Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 640
Yang, H., Zhang, W., Pan, H., Feldser, H. G., Lainez, E., Miller, C., Leung, S., Zhong, Z., Zhao, H., Sweitzer, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046364 · Cited by 377
Kocher, T., König, J., Borgnakke, W. S., Pink, C., & Meisel, P. (2018) · Periodontology 2000 · doi:10.1111/prd.12235 · Cited by 293
Calorie restriction as an intervention in ageing
López‐Lluch, G., & Navas, P. (2016) · The Journal of Physiology · doi:10.1113/jp270543 · Cited by 288
Oxidants, Antioxidants, and the Beneficial Roles of Exercise-Induced Production of Reactive Species
Gomes, E. C., Silva, A. N., & Oliveira, M. R. D. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/756132 · Cited by 287
Metadata
- Authors
- Chung, H. Y., Lee, E. K., Choi, Y. J., Kim, J. M., Kim, D. H., Zou, Y., Kim, C. H., Lee, J., Kim, H. S., Kim, N. D., Jung, J. H., & Yu, B. P.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2011-03-29
- Volume
- 90
- Issue
- 7
- Pages
- 830-840
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2160832259
- Cited by
- 215
- References
- 28
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chung, H. Y., Lee, E. K., Choi, Y. J., Kim, J. M., Kim, D. H., Zou, Y., Kim, C. H., Lee, J., Kim, H. S., Kim, N. D., Jung, J. H., & Yu, B. P. (2011). Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases. Journal of Dental Research. https://doi.org/10.1177/0022034510387794
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